Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

During development, the hematopoietic lineage transits through hemogenic endothelium, but the signaling pathways effecting this transition are incompletely characterized. Although the Hedgehog (Hh) pathway is hypothesized to play a role in patterning blood formation, early embryonic lethality of mic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (2), p.E141-E150
Hauptverfasser:	Kim, Peter Geon, Albacker, Colleen E, Lu, Yi-fen, Jang, Il-ho, Lim, Yoowon, Heffner, Garrett C, Arora, Natasha, Bowman, Teresa V, Lin, Michelle I, Lensch, M William, De Los Angeles, Alejandro, Zon, Leonard I, Loewer, Sabine, Daley, George Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - metabolism Biological Sciences blood cadherins Cell Differentiation - physiology Cells Colony-Forming Units Assay Danio rerio Embryo, Mammalian Embryos endothelium Endothelium - physiology Female Flow Cytometry Fluorescent Antibody Technique Gene Expression Profiling Hedgehog Proteins - metabolism hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology In Situ Hybridization lymphocytic leukemia Mice Mice, Inbred C57BL neoplasm cells PNAS Plus Proto-Oncogene Proteins - metabolism Receptors, Notch - metabolism Rodents Signal transduction Signal Transduction - physiology T-Cell Acute Lymphocytic Leukemia Protein 1 yolk sac Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!