Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice

Matrix metalloproteinase-2 (MMP-2) is responsible for the degradation of various types of extracellular matrix (ECM) proteins such as type IV collagen. Decreased MMP-2 expression and activity has been generally thought to contribute to increased accumulation of ECM at the advanced stage of diabetic...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2013-01, Vol.28 (1), p.55-62
Hauptverfasser:	Takamiya, Yoshimi, Fukami, Kei, Yamagishi, Sho-ichi, Kaida, Yusuke, Nakayama, Yosuke, Obara, Nana, Iwatani, Ryuji, Ando, Ryotaro, Koike, Kiyomi, Matsui, Takanori, Nishino, Yuri, Ueda, Seiji, Cooper, Mark E, Okuda, Seiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Diabetes Mellitus, Experimental - enzymology Diabetic Nephropathies - enzymology Immunohistochemistry Kidney - pathology Kidney - physiopathology Kidney Function Tests Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Mice, Knockout Real-Time Polymerase Chain Reaction
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