Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia

Summary Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine...

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Veröffentlicht in:Anaesthesia 2013-02, Vol.68 (2), p.136-141
Hauptverfasser: Wang, J., Ren, Y., Zhu, Y., Chen, J. W., Zhu, M. M., Xu, Y. J., Tan, Z. M.
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container_end_page 141
container_issue 2
container_start_page 136
container_title Anaesthesia
container_volume 68
creator Wang, J.
Ren, Y.
Zhu, Y.
Chen, J. W.
Zhu, M. M.
Xu, Y. J.
Tan, Z. M.
description Summary Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.
doi_str_mv 10.1111/anae.12092
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W.</creatorcontrib><creatorcontrib>Zhu, M. M.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Tan, Z. M.</creatorcontrib><title>Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia, General</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - surgery</subject><subject>China - epidemiology</subject><subject>Cholinergic Antagonists - pharmacology</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intraoperative Awareness - epidemiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quinuclidines - pharmacology</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-K1DAYxYMo7rh64wNIQAQRuiZN27SXwzD-gUVv9Lp8Tb5Ms3SSmrS79M5H8CV8MZ_E1BkVvDA3IZxfzsnJR8hTzq54Wq_BAV7xnDX5PbLhoiqznBXFfbJhjIksL1hzQR7FeMMYz2tePyQXuciFrFi5Id_3xqCaqDd0RIf9ogarrUPaLzp41Q8-WI3UOzr1SK1T6eQUrrx1U4AfX7_5EQNM9hYp3EFIJjEmje76ZBORjklDN0U6O43h4K070C4gxIkqSFaBxjkcMCxUz2EVD8kiwEDXWjGlRguPyQMDQ8Qn5_2SfH6z_7R7l11_fPt-t73OVJEqZaWRtWka0Rmta0RpVMkZdBIL1GUqbHQHhtdcdqYUAnhZSW0KAN1hle514pK8PPmOwX-ZU3p7tFHhMIBDP8eW51IIIUUpE_r8H_TGz8Gl1yWqkjmri7pI1KsTpYKPMaBpx2CPEJaWs3YdXru2bH8NL8HPzpZzd0T9B_09rQS8OAMQFQwmpP-z8S9XyUbW1crxE3dnB1z-E9luP2z3p_Cf_6e2_w</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Wang, J.</creator><creator>Ren, Y.</creator><creator>Zhu, Y.</creator><creator>Chen, J. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - surgery</topic><topic>China - epidemiology</topic><topic>Cholinergic Antagonists - pharmacology</topic><topic>Clinical trials</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intraoperative Awareness - epidemiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Quinuclidines - pharmacology</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Ren, Y.</creatorcontrib><creatorcontrib>Zhu, Y.</creatorcontrib><creatorcontrib>Chen, J. W.</creatorcontrib><creatorcontrib>Zhu, M. M.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Tan, Z. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2013-02</date><risdate>2013</risdate><volume>68</volume><issue>2</issue><spage>136</spage><epage>141</epage><pages>136-141</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.</abstract><cop>Oxford</cop><pub>Wiley-Blackwell</pub><pmid>23237605</pmid><doi>10.1111/anae.12092</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals
subjects Adolescent
Adult
Aged
Anesthesia
Anesthesia, General
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Breast cancer
Breast Neoplasms - surgery
China - epidemiology
Cholinergic Antagonists - pharmacology
Clinical trials
Double-Blind Method
Female
Humans
Incidence
Intraoperative Awareness - epidemiology
Medical sciences
Middle Aged
Prospective Studies
Quinuclidines - pharmacology
Surgery
Young Adult
title Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia
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