Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia
Summary Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine...
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Veröffentlicht in: | Anaesthesia 2013-02, Vol.68 (2), p.136-141 |
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description | Summary
Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia. |
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Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/anae.12092</identifier><identifier>PMID: 23237605</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford: Wiley-Blackwell</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia ; Anesthesia, General ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - surgery ; China - epidemiology ; Cholinergic Antagonists - pharmacology ; Clinical trials ; Double-Blind Method ; Female ; Humans ; Incidence ; Intraoperative Awareness - epidemiology ; Medical sciences ; Middle Aged ; Prospective Studies ; Quinuclidines - pharmacology ; Surgery ; Young Adult</subject><ispartof>Anaesthesia, 2013-02, Vol.68 (2), p.136-141</ispartof><rights>Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland</rights><rights>2014 INIST-CNRS</rights><rights>Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.</rights><rights>Copyright © 2013 The Association of Anaesthetists of Great Britain and Ireland</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4232-5f78f993bfdd8ee7fc510ab7e4ed5376fdbaf1817bf533a1567df4aadbe6f99b3</citedby><cites>FETCH-LOGICAL-c4232-5f78f993bfdd8ee7fc510ab7e4ed5376fdbaf1817bf533a1567df4aadbe6f99b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fanae.12092$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fanae.12092$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26797865$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23237605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Ren, Y.</creatorcontrib><creatorcontrib>Zhu, Y.</creatorcontrib><creatorcontrib>Chen, J. W.</creatorcontrib><creatorcontrib>Zhu, M. M.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Tan, Z. M.</creatorcontrib><title>Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia, General</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - surgery</subject><subject>China - epidemiology</subject><subject>Cholinergic Antagonists - pharmacology</subject><subject>Clinical trials</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intraoperative Awareness - epidemiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quinuclidines - pharmacology</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd-K1DAYxYMo7rh64wNIQAQRuiZN27SXwzD-gUVv9Lp8Tb5Ms3SSmrS79M5H8CV8MZ_E1BkVvDA3IZxfzsnJR8hTzq54Wq_BAV7xnDX5PbLhoiqznBXFfbJhjIksL1hzQR7FeMMYz2tePyQXuciFrFi5Id_3xqCaqDd0RIf9ogarrUPaLzp41Q8-WI3UOzr1SK1T6eQUrrx1U4AfX7_5EQNM9hYp3EFIJjEmje76ZBORjklDN0U6O43h4K070C4gxIkqSFaBxjkcMCxUz2EVD8kiwEDXWjGlRguPyQMDQ8Qn5_2SfH6z_7R7l11_fPt-t73OVJEqZaWRtWka0Rmta0RpVMkZdBIL1GUqbHQHhtdcdqYUAnhZSW0KAN1hle514pK8PPmOwX-ZU3p7tFHhMIBDP8eW51IIIUUpE_r8H_TGz8Gl1yWqkjmri7pI1KsTpYKPMaBpx2CPEJaWs3YdXru2bH8NL8HPzpZzd0T9B_09rQS8OAMQFQwmpP-z8S9XyUbW1crxE3dnB1z-E9luP2z3p_Cf_6e2_w</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Wang, J.</creator><creator>Ren, Y.</creator><creator>Zhu, Y.</creator><creator>Chen, J. W.</creator><creator>Zhu, M. M.</creator><creator>Xu, Y. J.</creator><creator>Tan, Z. M.</creator><general>Wiley-Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia</title><author>Wang, J. ; Ren, Y. ; Zhu, Y. ; Chen, J. W. ; Zhu, M. M. ; Xu, Y. J. ; Tan, Z. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4232-5f78f993bfdd8ee7fc510ab7e4ed5376fdbaf1817bf533a1567df4aadbe6f99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia, General</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - surgery</topic><topic>China - epidemiology</topic><topic>Cholinergic Antagonists - pharmacology</topic><topic>Clinical trials</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intraoperative Awareness - epidemiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Quinuclidines - pharmacology</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Ren, Y.</creatorcontrib><creatorcontrib>Zhu, Y.</creatorcontrib><creatorcontrib>Chen, J. W.</creatorcontrib><creatorcontrib>Zhu, M. M.</creatorcontrib><creatorcontrib>Xu, Y. J.</creatorcontrib><creatorcontrib>Tan, Z. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J.</au><au>Ren, Y.</au><au>Zhu, Y.</au><au>Chen, J. W.</au><au>Zhu, M. M.</au><au>Xu, Y. J.</au><au>Tan, Z. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2013-02</date><risdate>2013</risdate><volume>68</volume><issue>2</issue><spage>136</spage><epage>141</epage><pages>136-141</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
Intra‐operative awareness can lead to serious adverse psychological consequences. We conducted a prospective, randomised, double‐blinded trial in 920 patients undergoing breast cancer surgery under bispectral index‐guided total intravenous anaesthesia to evaluate the effect of penehyclidine hydrochloride on intra‐operative awareness. Patients were randomly divided to receive 0.01 mg.kg−1 penehyclidine hydrochloride or saline intravenously 30 min before surgery. The pre‐administration, pre‐operative anxiety levels were assessed using a 100‐mm visual analogue scale. Intra‐operative awareness was defined as recall of intra‐operative events using a modified Brice interview administered 2–6 h postoperatively, and in the next 24–48 h. A committee of three experts, blinded to the study conditions, independently scrutinised all reported recollections. We found no differences in depth of anaesthesia and patients' pre‐operative anxiety levels between the two groups. The incidence of awareness with penehyclidine hydrochloride (0/456 patients; 0%) was significantly lower than with saline (5/452; 1.1%), p = 0.030. We conclude that penehyclidine hydrochloride reduced the incidence of intra‐operative awareness in patients undergoing breast cancer surgery during general anaesthesia.</abstract><cop>Oxford</cop><pub>Wiley-Blackwell</pub><pmid>23237605</pmid><doi>10.1111/anae.12092</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Anesthesia Anesthesia, General Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Breast cancer Breast Neoplasms - surgery China - epidemiology Cholinergic Antagonists - pharmacology Clinical trials Double-Blind Method Female Humans Incidence Intraoperative Awareness - epidemiology Medical sciences Middle Aged Prospective Studies Quinuclidines - pharmacology Surgery Young Adult |
title | Effect of penehyclidine hydrochloride on the incidence of intra‐operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia |
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