Radioadaptive Response Following In Utero Low-Dose Irradiation
Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiatio...
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| Veröffentlicht in: | Radiation research 2013-01, Vol.179 (1), p.29-37 |
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| creator | Howell, Eric K. Gaschak, Sergey P. Griffith, Kenneth D. W. Rodgers, Brenda E. |
| description | Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiation exposures in utero. Pregnant laboratory mice (BALB/c) were exposed to low-dose Chernobyl radiation [10–13 mSv per day for 10 days] during organogenesis. The progeny were born and weaned in an uncontaminated laboratory, then were exposed to an acute radiation dose (2.4 Sv). Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100–130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure. |
| doi_str_mv | 10.1667/RR3029.1 |
| format | Article |
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W. ; Rodgers, Brenda E.</creator><creatorcontrib>Howell, Eric K. ; Gaschak, Sergey P. ; Griffith, Kenneth D. W. ; Rodgers, Brenda E.</creatorcontrib><description>Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiation exposures in utero. Pregnant laboratory mice (BALB/c) were exposed to low-dose Chernobyl radiation [10–13 mSv per day for 10 days] during organogenesis. The progeny were born and weaned in an uncontaminated laboratory, then were exposed to an acute radiation dose (2.4 Sv). Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100–130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.1667/RR3029.1</identifier><identifier>PMID: 23181589</identifier><language>eng</language><publisher>United States: The Radiation Research Society</publisher><subject>Adaptation, Physiological - radiation effects ; Animals ; Biological damage ; Body Weight - radiation effects ; Bone marrow ; Deoxyribonucleic acid ; DNA ; DNA Damage ; DNA repair ; Erythrocytes - cytology ; Erythrocytes - radiation effects ; Female ; Fetus - radiation effects ; Gene expression ; Genes ; Ionizing radiation ; Irradiation ; Leukocyte Count ; Litter Size - radiation effects ; Male ; Mice ; Mice, Inbred BALB C ; Offspring ; Pregnancy ; Radiation damage ; Radiation Dosage ; Radiotherapy ; REGULAR ARTICLES ; Space life sciences ; Stem cells ; Transcriptome - radiation effects ; Uterus - radiation effects ; Weaning</subject><ispartof>Radiation research, 2013-01, Vol.179 (1), p.29-37</ispartof><rights>Copyright © 2013 Radiation Research Society</rights><rights>Copyright Allen Press Publishing Services Jan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b364t-7495b40e2fd432546eab28ccf10c214e011d5014d44e807e56aff37d789c039c3</citedby><cites>FETCH-LOGICAL-b364t-7495b40e2fd432546eab28ccf10c214e011d5014d44e807e56aff37d789c039c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23325718$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23325718$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23181589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howell, Eric K.</creatorcontrib><creatorcontrib>Gaschak, Sergey P.</creatorcontrib><creatorcontrib>Griffith, Kenneth D. 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Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100–130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure.</description><subject>Adaptation, Physiological - radiation effects</subject><subject>Animals</subject><subject>Biological damage</subject><subject>Body Weight - radiation effects</subject><subject>Bone marrow</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>DNA repair</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - radiation effects</subject><subject>Female</subject><subject>Fetus - radiation effects</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Ionizing radiation</subject><subject>Irradiation</subject><subject>Leukocyte Count</subject><subject>Litter Size - radiation effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Radiation damage</subject><subject>Radiation Dosage</subject><subject>Radiotherapy</subject><subject>REGULAR ARTICLES</subject><subject>Space life sciences</subject><subject>Stem cells</subject><subject>Transcriptome - radiation effects</subject><subject>Uterus - radiation effects</subject><subject>Weaning</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kF9LwzAUxYMoOqfgF1AKgvjSmZukTfoiyHQ6GAjFPYe0TaWja2rSOvz2ZnT-QfDpcjm_e-69B6EzwBOIY36TphSTZAJ7aAQJFWHEMNtHI4wpDXkk-BE6dm6FfQ9xcoiOCAUBkUhG6DZVRWVUodquetdBql1rGqeDmalrs6ma12DeBMtOWxMszCa8N16bW-uHVFeZ5gQdlKp2-nRXx2g5e3iZPoWL58f59G4RZjRmXchZEmUMa1IWjJKIxVplROR5CTgnwDQGKCIMrGBMC8x1FKuypLzgIskxTXI6RteDb2vNW69dJ9eVy3Vdq0ab3kkgnFJIOAOPXv5BV6a3jb9OAgVKYkIw-THMrXHO6lK2tlor-yEBy22mcshUbg0vdoZ9ttbFN_gVogfOB2DlOmN_6f5VDsLrV4OeVcY0-v9NnymGhEw</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Howell, Eric K.</creator><creator>Gaschak, Sergey P.</creator><creator>Griffith, Kenneth D. 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W.</au><au>Rodgers, Brenda E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radioadaptive Response Following In Utero Low-Dose Irradiation</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>179</volume><issue>1</issue><spage>29</spage><epage>37</epage><pages>29-37</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Acute radiation exposure is known to cause biological damage that leads to severe health effects. However, the effects and subsequent health implications of exposure to low doses of ionizing radiation are unclear. The purpose of this study was to investigate the effects of low-dose ionizing radiation exposures in utero. Pregnant laboratory mice (BALB/c) were exposed to low-dose Chernobyl radiation [10–13 mSv per day for 10 days] during organogenesis. The progeny were born and weaned in an uncontaminated laboratory, then were exposed to an acute radiation dose (2.4 Sv). Analysis of our end points (litter dynamics, DNA damage, bone marrow stem cell function, white blood cell counts and gene expression) suggests that a low-dose (100–130 mSv) in utero exposure to ionizing radiation is not deleterious to the offspring. Rather DNA damage, white blood cell levels, and gene expression results suggest a radioadaptive response was elicited for the in utero exposure with respect to the effects of the subsequent acute radiation exposure.</abstract><cop>United States</cop><pub>The Radiation Research Society</pub><pmid>23181589</pmid><doi>10.1667/RR3029.1</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 2013-01, Vol.179 (1), p.29-37 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Adaptation, Physiological - radiation effects Animals Biological damage Body Weight - radiation effects Bone marrow Deoxyribonucleic acid DNA DNA Damage DNA repair Erythrocytes - cytology Erythrocytes - radiation effects Female Fetus - radiation effects Gene expression Genes Ionizing radiation Irradiation Leukocyte Count Litter Size - radiation effects Male Mice Mice, Inbred BALB C Offspring Pregnancy Radiation damage Radiation Dosage Radiotherapy REGULAR ARTICLES Space life sciences Stem cells Transcriptome - radiation effects Uterus - radiation effects Weaning |
| title | Radioadaptive Response Following In Utero Low-Dose Irradiation |
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