Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin-induced Diabetic Rats
The effect of chronic daidzein, a soybean isoflavone, on aortic reactivity of streptozotocin‐diabetic rats was studied. Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh)...
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| Veröffentlicht in: | Phytotherapy research 2013-01, Vol.27 (1), p.112-117 |
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| creator | Roghani, Mehrdad Vaez Mahdavi, Mohammad-Reza Jalali-Nadoushan, Mohammad-Reza Baluchnejadmojarad, Tourandokht Naderi, Gholamali Roghani-Dehkordi, Farshad Taghi Joghataei, Mohammad Kord, Maryam |
| description | The effect of chronic daidzein, a soybean isoflavone, on aortic reactivity of streptozotocin‐diabetic rats was studied. Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings. Maximum contractile response of endothelium‐intact rings to PE was significantly lower in daidzein‐treated diabetic rats relative to untreated diabetic rats, and endothelium removal abolished this difference. Endothelium‐dependent relaxation to ACh was significantly higher in daidzein‐treated diabetic rats as compared with diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor N(G)‐nitro‐l‐arginine methyl ester and/or indomethacin attenuated it. Two‐month diabetes also resulted in an elevation of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity, and daidzein treatment significantly reversed the increased MDA content and reduced activity of SOD. Therefore, chronic treatment of diabetic rats with daidzein could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and prostaglandin‐related pathways, and via attenuation of oxidative stress in aortic tissue and endothelium integrity seems essential for this effect. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.4699 |
| format | Article |
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Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings. Maximum contractile response of endothelium‐intact rings to PE was significantly lower in daidzein‐treated diabetic rats relative to untreated diabetic rats, and endothelium removal abolished this difference. Endothelium‐dependent relaxation to ACh was significantly higher in daidzein‐treated diabetic rats as compared with diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor N(G)‐nitro‐l‐arginine methyl ester and/or indomethacin attenuated it. Two‐month diabetes also resulted in an elevation of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity, and daidzein treatment significantly reversed the increased MDA content and reduced activity of SOD. Therefore, chronic treatment of diabetic rats with daidzein could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and prostaglandin‐related pathways, and via attenuation of oxidative stress in aortic tissue and endothelium integrity seems essential for this effect. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4699</identifier><identifier>PMID: 22511255</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; aorta ; Aorta - drug effects ; Aorta - physiopathology ; daidzein ; diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - physiopathology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Glycine max - chemistry ; Isoflavones - pharmacology ; Male ; Malondialdehyde - analysis ; oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Wistar ; streptozotocin ; Superoxide Dismutase - metabolism</subject><ispartof>Phytotherapy research, 2013-01, Vol.27 (1), p.112-117</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4539-f4459ebbf81a3218207dd3815f4d65d71bb601aec38514a478cf72c39dbc98193</citedby><cites>FETCH-LOGICAL-c4539-f4459ebbf81a3218207dd3815f4d65d71bb601aec38514a478cf72c39dbc98193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4699$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4699$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22511255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roghani, Mehrdad</creatorcontrib><creatorcontrib>Vaez Mahdavi, Mohammad-Reza</creatorcontrib><creatorcontrib>Jalali-Nadoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Baluchnejadmojarad, Tourandokht</creatorcontrib><creatorcontrib>Naderi, Gholamali</creatorcontrib><creatorcontrib>Roghani-Dehkordi, Farshad</creatorcontrib><creatorcontrib>Taghi Joghataei, Mohammad</creatorcontrib><creatorcontrib>Kord, Maryam</creatorcontrib><title>Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin-induced Diabetic Rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The effect of chronic daidzein, a soybean isoflavone, on aortic reactivity of streptozotocin‐diabetic rats was studied. Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings. Maximum contractile response of endothelium‐intact rings to PE was significantly lower in daidzein‐treated diabetic rats relative to untreated diabetic rats, and endothelium removal abolished this difference. Endothelium‐dependent relaxation to ACh was significantly higher in daidzein‐treated diabetic rats as compared with diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor N(G)‐nitro‐l‐arginine methyl ester and/or indomethacin attenuated it. Two‐month diabetes also resulted in an elevation of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity, and daidzein treatment significantly reversed the increased MDA content and reduced activity of SOD. Therefore, chronic treatment of diabetic rats with daidzein could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and prostaglandin‐related pathways, and via attenuation of oxidative stress in aortic tissue and endothelium integrity seems essential for this effect. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - physiopathology</subject><subject>daidzein</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Glycine max - chemistry</subject><subject>Isoflavones - pharmacology</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>streptozotocin</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEUQIModq2Cv0ACvvjQqfmYzCSPy25bF4uVbqV9C5kkQ1NnkzXJrN3-HH-pabtWEHy69-FwuJcDwFuMDjFC5OM6x8O6EeIZmGAkRIVZS5-DCRIMVzXmV3vgVUo3CCFBUP0S7BHCMCaMTcCv2XUM3mk4NSvnXcpRZRc8DD2cK2furPMHUMFl2HZWebhIoR_UJnh7ABerdQwbm-CRNyFf28GpAc63qR-9fnAob-A0Z-tHlQt2dutMkW8sXOZoU4LOP2zrHO5CDtr5ynkzamvg3KnO5nLVucrpNXjRqyHZN7u5D74dH13MPlWnZyeL2fS00jWjourrmgnbdT3HihLMCWqNoRyzvjYNMy3uugZhZTXlDNeqbrnuW6KpMJ0WHAu6Dz48estbP0absly5pO0wKG_DmCQmLaUYYcEL-v4f9CaM0ZfrCtVwhGrCyV-hjiGlaHu5jm6l4lZiJO-7ydJN3ncr6LudcOxW1jyBf0IVoHoEfrrBbv8rkl8vznfCHV-S2tsnXsXvsmlpy-TllxP5ebm8PMboSnL6Gy1Hs0E</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Roghani, Mehrdad</creator><creator>Vaez Mahdavi, Mohammad-Reza</creator><creator>Jalali-Nadoushan, Mohammad-Reza</creator><creator>Baluchnejadmojarad, Tourandokht</creator><creator>Naderi, Gholamali</creator><creator>Roghani-Dehkordi, Farshad</creator><creator>Taghi Joghataei, Mohammad</creator><creator>Kord, Maryam</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin-induced Diabetic Rats</title><author>Roghani, Mehrdad ; Vaez Mahdavi, Mohammad-Reza ; Jalali-Nadoushan, Mohammad-Reza ; Baluchnejadmojarad, Tourandokht ; Naderi, Gholamali ; Roghani-Dehkordi, Farshad ; Taghi Joghataei, Mohammad ; Kord, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4539-f4459ebbf81a3218207dd3815f4d65d71bb601aec38514a478cf72c39dbc98193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>aorta</topic><topic>Aorta - drug effects</topic><topic>Aorta - physiopathology</topic><topic>daidzein</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Glycine max - chemistry</topic><topic>Isoflavones - pharmacology</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>streptozotocin</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roghani, Mehrdad</creatorcontrib><creatorcontrib>Vaez Mahdavi, Mohammad-Reza</creatorcontrib><creatorcontrib>Jalali-Nadoushan, Mohammad-Reza</creatorcontrib><creatorcontrib>Baluchnejadmojarad, Tourandokht</creatorcontrib><creatorcontrib>Naderi, Gholamali</creatorcontrib><creatorcontrib>Roghani-Dehkordi, Farshad</creatorcontrib><creatorcontrib>Taghi Joghataei, Mohammad</creatorcontrib><creatorcontrib>Kord, Maryam</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roghani, Mehrdad</au><au>Vaez Mahdavi, Mohammad-Reza</au><au>Jalali-Nadoushan, Mohammad-Reza</au><au>Baluchnejadmojarad, Tourandokht</au><au>Naderi, Gholamali</au><au>Roghani-Dehkordi, Farshad</au><au>Taghi Joghataei, Mohammad</au><au>Kord, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin-induced Diabetic Rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2013-01</date><risdate>2013</risdate><volume>27</volume><issue>1</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The effect of chronic daidzein, a soybean isoflavone, on aortic reactivity of streptozotocin‐diabetic rats was studied. Male diabetic rats received daidzein for 7 weeks a week after diabetes induction. Contractile responses to KCl and phenylephrine (PE) and relaxation response to acetylcholine (ACh) were obtained from aortic rings. Maximum contractile response of endothelium‐intact rings to PE was significantly lower in daidzein‐treated diabetic rats relative to untreated diabetic rats, and endothelium removal abolished this difference. Endothelium‐dependent relaxation to ACh was significantly higher in daidzein‐treated diabetic rats as compared with diabetic rats and pretreatment of rings with nitric oxide synthase inhibitor N(G)‐nitro‐l‐arginine methyl ester and/or indomethacin attenuated it. Two‐month diabetes also resulted in an elevation of malondialdehyde (MDA) and decreased superoxide dismutase (SOD) activity, and daidzein treatment significantly reversed the increased MDA content and reduced activity of SOD. Therefore, chronic treatment of diabetic rats with daidzein could prevent some abnormal changes in vascular reactivity in diabetic rats through nitric oxide and prostaglandin‐related pathways, and via attenuation of oxidative stress in aortic tissue and endothelium integrity seems essential for this effect. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>22511255</pmid><doi>10.1002/ptr.4699</doi><tpages>6</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2013-01, Vol.27 (1), p.112-117 |
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| subjects | Animals aorta Aorta - drug effects Aorta - physiopathology daidzein diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Glycine max - chemistry Isoflavones - pharmacology Male Malondialdehyde - analysis oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar streptozotocin Superoxide Dismutase - metabolism |
| title | Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin-induced Diabetic Rats |
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