Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage
Abstract Background and aims The prevalence of recurrent miscarriage (RM) is about 1–3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM. Methods A group of women with RM was recruited into t...
Gespeichert in:
| Veröffentlicht in: | Early human development 2013-02, Vol.89 (2), p.95-100 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 100 |
|---|---|
| container_issue | 2 |
| container_start_page | 95 |
| container_title | Early human development |
| container_volume | 89 |
| creator | Liu, Chaodong Wang, Xian-Zhong Sun, Xin-Bo |
| description | Abstract Background and aims The prevalence of recurrent miscarriage (RM) is about 1–3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM. Methods A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry. Results Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells. Conclusions Immune deregulation may play an important role in RM. |
| doi_str_mv | 10.1016/j.earlhumdev.2012.08.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273310107</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0378378212001971</els_id><sourcerecordid>1273310107</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-3eb0b0ab6f379b99e726aae959fae68a692e78b6f02078f94b434d7029914f4b3</originalsourceid><addsrcrecordid>eNqNkk9v1DAQxS0EotvCV0C-IHFJGNtJbF-QSlUoUiUOlBMHy3HGWy_5s9hJq_32ONqFSpw4WCNr3pt5-mkIoQxKBqx5vyvRxv5-GTp8KDkwXoIqAcQzsmFK8qLhgj8nGxBSFfnxM3Ke0g4AaqXhJTnjXPNa1PWG_LhMCVMacJzp5GnaYxyoHeewxXH9ueCDo3c04nbp7TzFA3XY94mGkT5O2UYfw3yf226JcR0yhORsjMFu8RV54W2f8PWpXpDvn67vrm6K26-fv1xd3hauqvVcCGyhBds2Xkjdao2SN9airrW32CjbaI5S5TZwkMrrqq1E1UngWrPKV624IO-Oc_dx-rVgms0aIqe0I05LMoxLITI3kFmqjlIXp5QierOPYbDxYBiYFa3ZmSe0ZkVrQJmMNlvfnLYs7YDdX-Mfllnw9iSwGUHvox1dSE-6Rqq6kizrPh51mJk8BIwmuYCjwy5kjLPppvA_aT78M8T1YQx57088YNpNSxwzc8NMyh7zbT2F9RIYB2A6p_gNCDiyQw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1273310107</pqid></control><display><type>article</type><title>Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Liu, Chaodong ; Wang, Xian-Zhong ; Sun, Xin-Bo</creator><creatorcontrib>Liu, Chaodong ; Wang, Xian-Zhong ; Sun, Xin-Bo</creatorcontrib><description>Abstract Background and aims The prevalence of recurrent miscarriage (RM) is about 1–3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM. Methods A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry. Results Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells. Conclusions Immune deregulation may play an important role in RM.</description><identifier>ISSN: 0378-3782</identifier><identifier>EISSN: 1872-6232</identifier><identifier>DOI: 10.1016/j.earlhumdev.2012.08.003</identifier><identifier>PMID: 22925355</identifier><identifier>CODEN: EHDEDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Abortion, Habitual - diagnosis ; Abortion, Habitual - immunology ; Adult ; Advanced Basic Science ; Antigens, Surface - analysis ; Antigens, Surface - immunology ; Biological and medical sciences ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Human study ; Humans ; Male ; Neonatal and Perinatal Medicine ; Pregnancy ; Recurrent miscarriage ; Regulatory T cell ; Sperm ; Spermatozoa - chemistry ; Spermatozoa - immunology ; T-Lymphocytes, Regulatory - chemistry ; T-Lymphocytes, Regulatory - immunology ; Th1 Cells - chemistry ; Th1 Cells - immunology ; Ubiquitin-Conjugating Enzymes - analysis</subject><ispartof>Early human development, 2013-02, Vol.89 (2), p.95-100</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-3eb0b0ab6f379b99e726aae959fae68a692e78b6f02078f94b434d7029914f4b3</citedby><cites>FETCH-LOGICAL-c459t-3eb0b0ab6f379b99e726aae959fae68a692e78b6f02078f94b434d7029914f4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.earlhumdev.2012.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26785471$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22925355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chaodong</creatorcontrib><creatorcontrib>Wang, Xian-Zhong</creatorcontrib><creatorcontrib>Sun, Xin-Bo</creatorcontrib><title>Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage</title><title>Early human development</title><addtitle>Early Hum Dev</addtitle><description>Abstract Background and aims The prevalence of recurrent miscarriage (RM) is about 1–3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM. Methods A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry. Results Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells. Conclusions Immune deregulation may play an important role in RM.</description><subject>Abortion, Habitual - diagnosis</subject><subject>Abortion, Habitual - immunology</subject><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Antigens, Surface - analysis</subject><subject>Antigens, Surface - immunology</subject><subject>Biological and medical sciences</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human study</subject><subject>Humans</subject><subject>Male</subject><subject>Neonatal and Perinatal Medicine</subject><subject>Pregnancy</subject><subject>Recurrent miscarriage</subject><subject>Regulatory T cell</subject><subject>Sperm</subject><subject>Spermatozoa - chemistry</subject><subject>Spermatozoa - immunology</subject><subject>T-Lymphocytes, Regulatory - chemistry</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th1 Cells - chemistry</subject><subject>Th1 Cells - immunology</subject><subject>Ubiquitin-Conjugating Enzymes - analysis</subject><issn>0378-3782</issn><issn>1872-6232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxS0EotvCV0C-IHFJGNtJbF-QSlUoUiUOlBMHy3HGWy_5s9hJq_32ONqFSpw4WCNr3pt5-mkIoQxKBqx5vyvRxv5-GTp8KDkwXoIqAcQzsmFK8qLhgj8nGxBSFfnxM3Ke0g4AaqXhJTnjXPNa1PWG_LhMCVMacJzp5GnaYxyoHeewxXH9ueCDo3c04nbp7TzFA3XY94mGkT5O2UYfw3yf226JcR0yhORsjMFu8RV54W2f8PWpXpDvn67vrm6K26-fv1xd3hauqvVcCGyhBds2Xkjdao2SN9airrW32CjbaI5S5TZwkMrrqq1E1UngWrPKV624IO-Oc_dx-rVgms0aIqe0I05LMoxLITI3kFmqjlIXp5QierOPYbDxYBiYFa3ZmSe0ZkVrQJmMNlvfnLYs7YDdX-Mfllnw9iSwGUHvox1dSE-6Rqq6kizrPh51mJk8BIwmuYCjwy5kjLPppvA_aT78M8T1YQx57088YNpNSxwzc8NMyh7zbT2F9RIYB2A6p_gNCDiyQw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Liu, Chaodong</creator><creator>Wang, Xian-Zhong</creator><creator>Sun, Xin-Bo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage</title><author>Liu, Chaodong ; Wang, Xian-Zhong ; Sun, Xin-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-3eb0b0ab6f379b99e726aae959fae68a692e78b6f02078f94b434d7029914f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abortion, Habitual - diagnosis</topic><topic>Abortion, Habitual - immunology</topic><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Antigens, Surface - analysis</topic><topic>Antigens, Surface - immunology</topic><topic>Biological and medical sciences</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human study</topic><topic>Humans</topic><topic>Male</topic><topic>Neonatal and Perinatal Medicine</topic><topic>Pregnancy</topic><topic>Recurrent miscarriage</topic><topic>Regulatory T cell</topic><topic>Sperm</topic><topic>Spermatozoa - chemistry</topic><topic>Spermatozoa - immunology</topic><topic>T-Lymphocytes, Regulatory - chemistry</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Th1 Cells - chemistry</topic><topic>Th1 Cells - immunology</topic><topic>Ubiquitin-Conjugating Enzymes - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chaodong</creatorcontrib><creatorcontrib>Wang, Xian-Zhong</creatorcontrib><creatorcontrib>Sun, Xin-Bo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Early human development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chaodong</au><au>Wang, Xian-Zhong</au><au>Sun, Xin-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage</atitle><jtitle>Early human development</jtitle><addtitle>Early Hum Dev</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>89</volume><issue>2</issue><spage>95</spage><epage>100</epage><pages>95-100</pages><issn>0378-3782</issn><eissn>1872-6232</eissn><coden>EHDEDN</coden><abstract>Abstract Background and aims The prevalence of recurrent miscarriage (RM) is about 1–3% of women; the pathogenesis of RM is not fully understood yet. This study aims to assess the sperm antigen specific regulatory T cells (Treg) in women with RM. Methods A group of women with RM was recruited into this study. The sperm antigen was extracted from the semen samples of each woman's husband. The sperm antigen specific T cell response was assessed by flow cytometry. Results Low frequency of sperm specific Tregs and high frequency of T helper (Th)1 cells were detected in RM women as compared with women without RM. The sperm specific Tregs in RM women expressed less Ubc13. Knockdown of Ubc13 from Tregs converted the Tregs to effector T cells. Conclusions Immune deregulation may play an important role in RM.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>22925355</pmid><doi>10.1016/j.earlhumdev.2012.08.003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-3782 |
| ispartof | Early human development, 2013-02, Vol.89 (2), p.95-100 |
| issn | 0378-3782 1872-6232 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1273310107 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abortion, Habitual - diagnosis Abortion, Habitual - immunology Adult Advanced Basic Science Antigens, Surface - analysis Antigens, Surface - immunology Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Human study Humans Male Neonatal and Perinatal Medicine Pregnancy Recurrent miscarriage Regulatory T cell Sperm Spermatozoa - chemistry Spermatozoa - immunology T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - immunology Th1 Cells - chemistry Th1 Cells - immunology Ubiquitin-Conjugating Enzymes - analysis |
| title | Assessment of sperm antigen specific T regulatory cells in women with recurrent miscarriage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A05%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20sperm%20antigen%20specific%20T%20regulatory%20cells%20in%20women%20with%20recurrent%20miscarriage&rft.jtitle=Early%20human%20development&rft.au=Liu,%20Chaodong&rft.date=2013-02-01&rft.volume=89&rft.issue=2&rft.spage=95&rft.epage=100&rft.pages=95-100&rft.issn=0378-3782&rft.eissn=1872-6232&rft.coden=EHDEDN&rft_id=info:doi/10.1016/j.earlhumdev.2012.08.003&rft_dat=%3Cproquest_cross%3E1273310107%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1273310107&rft_id=info:pmid/22925355&rft_els_id=1_s2_0_S0378378212001971&rfr_iscdi=true |