Reconstitution of the human cytoplasmic dynein complex

Cytoplasmic dynein is the major motor protein responsible for microtubule minus-end–directed movements in most eukaryotic cells. It transports a variety of cargoes and has numerous functions during spindle assembly and chromosome segregation. It is a large complex of about 1.4 MDa composed of six di...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (51), p.20895-20900
Hauptverfasser:	Trokter, Martina, Mücke, Norbert, Surrey, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Catalysis Chromatography, Gel - methods chromosome segregation Cytoplasm Cytoplasm - metabolism Cytoplasmic Dyneins - chemistry Dictyostelium Dimerization Dimers dynein ATPase Dyneins - chemistry electron microscopy Escherichia coli - metabolism Eukaryotes eukaryotic cells Fluorescence fluorescence microscopy gel chromatography Gels Gliding Humans Microscopy Microscopy, Electron - methods Microtubules Microtubules - metabolism molecular motor proteins Molecular Motor Proteins - chemistry Molecules Motility Motors Protein Binding Protein Conformation Protein Structure, Tertiary Proteins Recombinant Proteins - chemistry Ultracentrifugation Yeasts
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