Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats

Background/Aims Statins, which are inhibitors of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase and inhibit endogenous cholesterol synthesis, possess pleiotropic activities, such as anti‐inflammatory, anti‐oxidative and antifibrotic effects. Here, we investigated whether statins ameliorate steatohe...

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Veröffentlicht in:	Liver international 2013-02, Vol.33 (2), p.301-311
Hauptverfasser:	Okada, Yoshihisa, Yamaguchi, Kanji, Nakajima, Tomoki, Nishikawa, Taichiroh, Jo, Masayasu, Mitsumoto, Yasuhide, Kimura, Hiroyuki, Nishimura, Takeshi, Tochiki, Nozomi, Yasui, Kohichiroh, Mitsuyoshi, Hironori, Minami, Masahito, Kagawa, Keizo, Okanoue, Takeshi, Itoh, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase, Long-Chain - metabolism Acyl-CoA Oxidase - metabolism Alanine Transaminase - blood Animals Azo Compounds Carnitine O-Palmitoyltransferase - metabolism Catalase - metabolism Cholesterol - blood Cholesterol, Dietary - adverse effects Diet, High-Fat - adverse effects DNA Primers - genetics Enzyme-Linked Immunosorbent Assay Fatty Acids, Nonesterified - metabolism Fatty Liver - drug therapy Fatty Liver - etiology Fluorobenzenes - pharmacology Fluorobenzenes - therapeutic use high-fat and high-cholesterol diets Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Immunohistochemistry Liver - pathology Male NASH Non-alcoholic Fatty Liver Disease Pyrimidines - pharmacology Pyrimidines - therapeutic use Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction rosuvastatin Rosuvastatin Calcium Sulfonamides - pharmacology Sulfonamides - therapeutic use
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