Whole-genome association study for energy balance and fat/protein ratio in German Holstein bull dams
Summary The metabolic status of cows is important to health and fertility, especially in early lactation, and energy balance (EB) and fat/protein ratio (FPR) are considered as appropriate indicators for metabolic disorders. The aim of this study was to detect SNPs (single nucleotide polymorphisms) a...
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| Veröffentlicht in: | Animal genetics 2013-02, Vol.44 (1), p.1-8 |
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| creator | Tetens, J. Seidenspinner, T. Buttchereit, N. Thaller, G. |
| description | Summary
The metabolic status of cows is important to health and fertility, especially in early lactation, and energy balance (EB) and fat/protein ratio (FPR) are considered as appropriate indicators for metabolic disorders. The aim of this study was to detect SNPs (single nucleotide polymorphisms) associated with EB and FPR in German Holstein bull dams belonging to the research herd Karkendamm. Bull dams were genotyped using the Illumina Bovine SNP 50K Bead chip® comprising 54 001 SNPs. A total of 43 593 SNPs and 586 (EB) and 668 (FPR) bull dams passed the quality control criteria. Phenotypes were deregressed breeding values estimated via random regression animal models for lactation days 11, 20, 30, and 42 for EB and FPR. Whole‐genome association analyses were carried out fitting principal components as covariates to adjust for genetic substructure. Permutation tests were applied to estimate genome‐wise significance. Across all observed lactation days, 19 SNPs located in four different intervals on chromosomes 1, 14, 16, and 27 were detected. For EB, seven markers across four chromosomes were identified. There was no overlap between markers associated with FPR and EB. SNPs associated with FPR were mostly located in QTL regions for milk production traits, especially in the region of
DGAT1, whereas SNPs associated with EB mainly showed positional relationships to previously described QTL regions affecting functional traits, especially fertility. |
| doi_str_mv | 10.1111/j.1365-2052.2012.02357.x |
| format | Article |
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The metabolic status of cows is important to health and fertility, especially in early lactation, and energy balance (EB) and fat/protein ratio (FPR) are considered as appropriate indicators for metabolic disorders. The aim of this study was to detect SNPs (single nucleotide polymorphisms) associated with EB and FPR in German Holstein bull dams belonging to the research herd Karkendamm. Bull dams were genotyped using the Illumina Bovine SNP 50K Bead chip® comprising 54 001 SNPs. A total of 43 593 SNPs and 586 (EB) and 668 (FPR) bull dams passed the quality control criteria. Phenotypes were deregressed breeding values estimated via random regression animal models for lactation days 11, 20, 30, and 42 for EB and FPR. Whole‐genome association analyses were carried out fitting principal components as covariates to adjust for genetic substructure. Permutation tests were applied to estimate genome‐wise significance. Across all observed lactation days, 19 SNPs located in four different intervals on chromosomes 1, 14, 16, and 27 were detected. For EB, seven markers across four chromosomes were identified. There was no overlap between markers associated with FPR and EB. SNPs associated with FPR were mostly located in QTL regions for milk production traits, especially in the region of
DGAT1, whereas SNPs associated with EB mainly showed positional relationships to previously described QTL regions affecting functional traits, especially fertility.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/j.1365-2052.2012.02357.x</identifier><identifier>PMID: 22497605</identifier><identifier>CODEN: ANGEE3</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; association study ; Cattle - genetics ; Cattle - metabolism ; energy balance ; Energy Metabolism ; fat protein ration ; Fats - metabolism ; Female ; Genome-Wide Association Study ; Germany ; Lactation ; Models, Biological ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymorphism, Single Nucleotide ; Proteins - metabolism ; Quantitative Trait Loci ; Regression Analysis</subject><ispartof>Animal genetics, 2013-02, Vol.44 (1), p.1-8</ispartof><rights>2012 The Authors, Animal Genetics © 2012 Stichting International Society for Animal Genetics</rights><rights>2012 The Authors, Animal Genetics © 2012 Stichting International Society for Animal Genetics.</rights><rights>Animal Genetics © 2013 Stichting International Foundation for Animal Genetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2052.2012.02357.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2052.2012.02357.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22497605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tetens, J.</creatorcontrib><creatorcontrib>Seidenspinner, T.</creatorcontrib><creatorcontrib>Buttchereit, N.</creatorcontrib><creatorcontrib>Thaller, G.</creatorcontrib><title>Whole-genome association study for energy balance and fat/protein ratio in German Holstein bull dams</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>Summary
The metabolic status of cows is important to health and fertility, especially in early lactation, and energy balance (EB) and fat/protein ratio (FPR) are considered as appropriate indicators for metabolic disorders. The aim of this study was to detect SNPs (single nucleotide polymorphisms) associated with EB and FPR in German Holstein bull dams belonging to the research herd Karkendamm. Bull dams were genotyped using the Illumina Bovine SNP 50K Bead chip® comprising 54 001 SNPs. A total of 43 593 SNPs and 586 (EB) and 668 (FPR) bull dams passed the quality control criteria. Phenotypes were deregressed breeding values estimated via random regression animal models for lactation days 11, 20, 30, and 42 for EB and FPR. Whole‐genome association analyses were carried out fitting principal components as covariates to adjust for genetic substructure. Permutation tests were applied to estimate genome‐wise significance. Across all observed lactation days, 19 SNPs located in four different intervals on chromosomes 1, 14, 16, and 27 were detected. For EB, seven markers across four chromosomes were identified. There was no overlap between markers associated with FPR and EB. SNPs associated with FPR were mostly located in QTL regions for milk production traits, especially in the region of
DGAT1, whereas SNPs associated with EB mainly showed positional relationships to previously described QTL regions affecting functional traits, especially fertility.</description><subject>Animals</subject><subject>association study</subject><subject>Cattle - genetics</subject><subject>Cattle - metabolism</subject><subject>energy balance</subject><subject>Energy Metabolism</subject><subject>fat protein ration</subject><subject>Fats - metabolism</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>Germany</subject><subject>Lactation</subject><subject>Models, Biological</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - metabolism</subject><subject>Quantitative Trait Loci</subject><subject>Regression Analysis</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O3DAUhS3UqkxpXwFZ6qabBNvxT7JggUYwUwm1KoKytOz4hmZIYmonYubtcRg6i67qja90vmNdn4MQpiSn6ZxtclpIkTEiWM4IZTlhhVD59ggtDsI7tCBMlllFuTxGH2PcEEJKqugHdMwYr5QkYoHc_W_fQfYAg-8Bmxh93Zqx9QOO4-R2uPEBwwDhYYet6cxQJ2hwuDHj2VPwI7QDDjOP07CC0JsBr30XXwU7dR12po-f0PvGdBE-v90n6O7q8na5zq5_rL4tL66ztpBcZVUjG1FX3ArHHXFAqOO8qo2RslK1YsxaaQ0Bq2RTV5YbShQpK0YJlLVhUJygr_t302p_Joij7ttYQ5f2Bj9FTZkqCiJTDP-DJphRyRP65R9046cwpI9oKlgpWEpZJur0jZpsD04_hbY3Yaf_Rp2A8z3w3HawO-iU6LlSvdFzc3puTs-V6tdK9VZfrC7nKfmzvb9N6W4PfhMetVSFEvr--0qrm19s_ZMu9U3xAqfyopI</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Tetens, J.</creator><creator>Seidenspinner, T.</creator><creator>Buttchereit, N.</creator><creator>Thaller, G.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Whole-genome association study for energy balance and fat/protein ratio in German Holstein bull dams</title><author>Tetens, J. ; Seidenspinner, T. ; Buttchereit, N. ; Thaller, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3647-9f6f5c94b5d4d0de01d449caa6697c722bb6ba0eb76fc9b4a107089210e8ca2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>association study</topic><topic>Cattle - genetics</topic><topic>Cattle - metabolism</topic><topic>energy balance</topic><topic>Energy Metabolism</topic><topic>fat protein ration</topic><topic>Fats - metabolism</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>Germany</topic><topic>Lactation</topic><topic>Models, Biological</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - metabolism</topic><topic>Quantitative Trait Loci</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tetens, J.</creatorcontrib><creatorcontrib>Seidenspinner, T.</creatorcontrib><creatorcontrib>Buttchereit, N.</creatorcontrib><creatorcontrib>Thaller, G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tetens, J.</au><au>Seidenspinner, T.</au><au>Buttchereit, N.</au><au>Thaller, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-genome association study for energy balance and fat/protein ratio in German Holstein bull dams</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2013-02</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><coden>ANGEE3</coden><abstract>Summary
The metabolic status of cows is important to health and fertility, especially in early lactation, and energy balance (EB) and fat/protein ratio (FPR) are considered as appropriate indicators for metabolic disorders. The aim of this study was to detect SNPs (single nucleotide polymorphisms) associated with EB and FPR in German Holstein bull dams belonging to the research herd Karkendamm. Bull dams were genotyped using the Illumina Bovine SNP 50K Bead chip® comprising 54 001 SNPs. A total of 43 593 SNPs and 586 (EB) and 668 (FPR) bull dams passed the quality control criteria. Phenotypes were deregressed breeding values estimated via random regression animal models for lactation days 11, 20, 30, and 42 for EB and FPR. Whole‐genome association analyses were carried out fitting principal components as covariates to adjust for genetic substructure. Permutation tests were applied to estimate genome‐wise significance. Across all observed lactation days, 19 SNPs located in four different intervals on chromosomes 1, 14, 16, and 27 were detected. For EB, seven markers across four chromosomes were identified. There was no overlap between markers associated with FPR and EB. SNPs associated with FPR were mostly located in QTL regions for milk production traits, especially in the region of
DGAT1, whereas SNPs associated with EB mainly showed positional relationships to previously described QTL regions affecting functional traits, especially fertility.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22497605</pmid><doi>10.1111/j.1365-2052.2012.02357.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals association study Cattle - genetics Cattle - metabolism energy balance Energy Metabolism fat protein ration Fats - metabolism Female Genome-Wide Association Study Germany Lactation Models, Biological Oligonucleotide Array Sequence Analysis Phenotype Polymorphism, Single Nucleotide Proteins - metabolism Quantitative Trait Loci Regression Analysis |
| title | Whole-genome association study for energy balance and fat/protein ratio in German Holstein bull dams |
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