L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations

The cyanobacterial β-N-methylamino-L-alanine (L-BMAA) is described as a low-potency excitotoxin, possibly a factor in the increased incidence of amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) in Guam. The latter association is intensively disputed, as L-BMAA concentratio...

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Veröffentlicht in:	Toxicological sciences 2013-01, Vol.131 (1), p.217-224
Hauptverfasser:	Okle, Oliver, Stemmer, Kerstin, Deschl, Ulrich, Dietrich, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Diamino - toxicity Amyotrophic Lateral Sclerosis - chemically induced Amyotrophic Lateral Sclerosis - epidemiology Amyotrophic Lateral Sclerosis - metabolism Caspase 12 - metabolism Cell Culture Techniques Cell Line, Tumor Cell Survival - drug effects Dose-Response Relationship, Drug Endoplasmic Reticulum Stress - drug effects Excitatory Amino Acid Agonists - toxicity Guam - epidemiology HEK293 Cells Humans Parkinson Disease - epidemiology Parkinson Disease - metabolism Protein Binding Protein Folding Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Supranuclear Palsy, Progressive - chemically induced Supranuclear Palsy, Progressive - epidemiology Supranuclear Palsy, Progressive - metabolism Ubiquitinated Proteins - metabolism
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