Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology
Abstract Objective The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic fe...
Gespeichert in:
| Veröffentlicht in: | Placenta (Eastbourne) 2013-01, Vol.34 (1), p.62-66 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 66 |
|---|---|
| container_issue | 1 |
| container_start_page | 62 |
| container_title | Placenta (Eastbourne) |
| container_volume | 34 |
| creator | Proctor, L.K Fitzgerald, B Whittle, W.L Mokhtari, N Lee, E Machin, G Kingdom, J.C.P Keating, S.J |
| description | Abstract Objective The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic features and perinatal outcome. Study design We prospectively collected 497 umbilical cords between 18 and 41 weeks' gestation over a 1-year period. Fresh-tissue UCD were grouped according to gestational age and compared to sonographic and histological measurements. Associations between UCD percentile and placental pathologic findings or obstetrical outcomes were examined. Results Mean UCD increased with gestational age until a plateau at 1.0 cm in the third trimester, a value that was 0.56 cm less than sonographic measurements prior to delivery and 0.17 cm greater than UCD measured histologically. Umbilical cord components varied with UCD percentile, with umbilical vessel area increased in thick cords ( p |
| doi_str_mv | 10.1016/j.placenta.2012.10.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1273266742</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0143400412004080</els_id><sourcerecordid>1273266742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-48f7454fdeb2f38b99ba9ceea9610084521808f91c3a87f84083cbdedd3cba843</originalsourceid><addsrcrecordid>eNqFkkuP0zAQgC0EYsvCX1j5gsQlxa8kzgWBVryklTjAni3HnrQuThxsZ1H_PQ5tQeLCxSONvhmPPw9CN5RsKaHN68N29trAlPWWEcpKckto_QhtaM1ZxSlhj9GGUMErQYi4Qs9SOhBCOkHZU3TFOG0FFXKDdvdj77wz2mMTosXW6REyRDxDXNs7D9gs8QES1pPFeQ8urmQEr7MLE84B9y7mPf4JbrfPv6nLaB7POu-DD7vjc_Rk0D7Bi3O8Rvcf3n-7_VTdffn4-fbdXWVEzXMl5NCKWgwWejZw2XddrzsDoLuGEiJFzagkcuio4Vq2gxREctNbsLYELQW_Rq9OfecYfiyQshpdMuC9niAsSVHWctY0rWAFbU6oiSGlCIOaoxt1PCpK1CpZHdTlJWqVvOaL5FJ4c75j6Uewf8ouVgvw8gzoVMwOUU_Gpb9c08q6Zk3h3p44KEYeHESVjIPJgHURTFY2uP_P8uafFsa7af3P73CEdAhLnIpvRVViiqiv60qsG0FZOYgk_BfZbbRR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1273266742</pqid></control><display><type>article</type><title>Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Proctor, L.K ; Fitzgerald, B ; Whittle, W.L ; Mokhtari, N ; Lee, E ; Machin, G ; Kingdom, J.C.P ; Keating, S.J</creator><creatorcontrib>Proctor, L.K ; Fitzgerald, B ; Whittle, W.L ; Mokhtari, N ; Lee, E ; Machin, G ; Kingdom, J.C.P ; Keating, S.J</creatorcontrib><description>Abstract Objective The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic features and perinatal outcome. Study design We prospectively collected 497 umbilical cords between 18 and 41 weeks' gestation over a 1-year period. Fresh-tissue UCD were grouped according to gestational age and compared to sonographic and histological measurements. Associations between UCD percentile and placental pathologic findings or obstetrical outcomes were examined. Results Mean UCD increased with gestational age until a plateau at 1.0 cm in the third trimester, a value that was 0.56 cm less than sonographic measurements prior to delivery and 0.17 cm greater than UCD measured histologically. Umbilical cord components varied with UCD percentile, with umbilical vessel area increased in thick cords ( p < 0.001) and Wharton's jelly area reduced in thin cords ( p = 0.002). Thin umbilical cords were associated with at least one pathologic histological placental finding ( p = 0.02), low placental weight ( p < 0.001), single umbilical artery ( p = 0.02), marginal cord insertion ( p = 0.01), and low infant birth weight ( p < 0.001). Conclusions This study provides reference curves for post-delivery UCD from 18 to 41 weeks' gestation for use by perinatal pathologists. We show that increased UCD is a function of increased umbilical blood vessel volume and decreased UCD is a function of decreased Wharton's jelly volume. UCD shows a strong association with placental and infant birth weight.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2012.10.015</identifier><identifier>PMID: 23174148</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Birth weight ; Birth Weight - physiology ; Cohort Studies ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Growth Charts ; Humans ; Infant, Newborn ; Internal Medicine ; Nomogram ; Obstetrics and Gynecology ; Organ Size ; Pathology ; Percentile curve ; Placenta ; Placenta Diseases - etiology ; Placenta Diseases - pathology ; Pregnancy ; Pregnancy Outcome ; Prognosis ; Umbilical Cord - anatomy & histology ; Umbilical Cord - growth & development ; Umbilical Cord - pathology ; Umbilical cord diameter ; Wharton Jelly - growth & development ; Wharton Jelly - pathology</subject><ispartof>Placenta (Eastbourne), 2013-01, Vol.34 (1), p.62-66</ispartof><rights>2012</rights><rights>2014 INIST-CNRS</rights><rights>Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-48f7454fdeb2f38b99ba9ceea9610084521808f91c3a87f84083cbdedd3cba843</citedby><cites>FETCH-LOGICAL-c453t-48f7454fdeb2f38b99ba9ceea9610084521808f91c3a87f84083cbdedd3cba843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400412004080$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26785526$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23174148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Proctor, L.K</creatorcontrib><creatorcontrib>Fitzgerald, B</creatorcontrib><creatorcontrib>Whittle, W.L</creatorcontrib><creatorcontrib>Mokhtari, N</creatorcontrib><creatorcontrib>Lee, E</creatorcontrib><creatorcontrib>Machin, G</creatorcontrib><creatorcontrib>Kingdom, J.C.P</creatorcontrib><creatorcontrib>Keating, S.J</creatorcontrib><title>Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Objective The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic features and perinatal outcome. Study design We prospectively collected 497 umbilical cords between 18 and 41 weeks' gestation over a 1-year period. Fresh-tissue UCD were grouped according to gestational age and compared to sonographic and histological measurements. Associations between UCD percentile and placental pathologic findings or obstetrical outcomes were examined. Results Mean UCD increased with gestational age until a plateau at 1.0 cm in the third trimester, a value that was 0.56 cm less than sonographic measurements prior to delivery and 0.17 cm greater than UCD measured histologically. Umbilical cord components varied with UCD percentile, with umbilical vessel area increased in thick cords ( p < 0.001) and Wharton's jelly area reduced in thin cords ( p = 0.002). Thin umbilical cords were associated with at least one pathologic histological placental finding ( p = 0.02), low placental weight ( p < 0.001), single umbilical artery ( p = 0.02), marginal cord insertion ( p = 0.01), and low infant birth weight ( p < 0.001). Conclusions This study provides reference curves for post-delivery UCD from 18 to 41 weeks' gestation for use by perinatal pathologists. We show that increased UCD is a function of increased umbilical blood vessel volume and decreased UCD is a function of decreased Wharton's jelly volume. UCD shows a strong association with placental and infant birth weight.</description><subject>Biological and medical sciences</subject><subject>Birth weight</subject><subject>Birth Weight - physiology</subject><subject>Cohort Studies</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Growth Charts</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Internal Medicine</subject><subject>Nomogram</subject><subject>Obstetrics and Gynecology</subject><subject>Organ Size</subject><subject>Pathology</subject><subject>Percentile curve</subject><subject>Placenta</subject><subject>Placenta Diseases - etiology</subject><subject>Placenta Diseases - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prognosis</subject><subject>Umbilical Cord - anatomy & histology</subject><subject>Umbilical Cord - growth & development</subject><subject>Umbilical Cord - pathology</subject><subject>Umbilical cord diameter</subject><subject>Wharton Jelly - growth & development</subject><subject>Wharton Jelly - pathology</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP0zAQgC0EYsvCX1j5gsQlxa8kzgWBVryklTjAni3HnrQuThxsZ1H_PQ5tQeLCxSONvhmPPw9CN5RsKaHN68N29trAlPWWEcpKckto_QhtaM1ZxSlhj9GGUMErQYi4Qs9SOhBCOkHZU3TFOG0FFXKDdvdj77wz2mMTosXW6REyRDxDXNs7D9gs8QES1pPFeQ8urmQEr7MLE84B9y7mPf4JbrfPv6nLaB7POu-DD7vjc_Rk0D7Bi3O8Rvcf3n-7_VTdffn4-fbdXWVEzXMl5NCKWgwWejZw2XddrzsDoLuGEiJFzagkcuio4Vq2gxREctNbsLYELQW_Rq9OfecYfiyQshpdMuC9niAsSVHWctY0rWAFbU6oiSGlCIOaoxt1PCpK1CpZHdTlJWqVvOaL5FJ4c75j6Uewf8ouVgvw8gzoVMwOUU_Gpb9c08q6Zk3h3p44KEYeHESVjIPJgHURTFY2uP_P8uafFsa7af3P73CEdAhLnIpvRVViiqiv60qsG0FZOYgk_BfZbbRR</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Proctor, L.K</creator><creator>Fitzgerald, B</creator><creator>Whittle, W.L</creator><creator>Mokhtari, N</creator><creator>Lee, E</creator><creator>Machin, G</creator><creator>Kingdom, J.C.P</creator><creator>Keating, S.J</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology</title><author>Proctor, L.K ; Fitzgerald, B ; Whittle, W.L ; Mokhtari, N ; Lee, E ; Machin, G ; Kingdom, J.C.P ; Keating, S.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-48f7454fdeb2f38b99ba9ceea9610084521808f91c3a87f84083cbdedd3cba843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biological and medical sciences</topic><topic>Birth weight</topic><topic>Birth Weight - physiology</topic><topic>Cohort Studies</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Growth Charts</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Internal Medicine</topic><topic>Nomogram</topic><topic>Obstetrics and Gynecology</topic><topic>Organ Size</topic><topic>Pathology</topic><topic>Percentile curve</topic><topic>Placenta</topic><topic>Placenta Diseases - etiology</topic><topic>Placenta Diseases - pathology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prognosis</topic><topic>Umbilical Cord - anatomy & histology</topic><topic>Umbilical Cord - growth & development</topic><topic>Umbilical Cord - pathology</topic><topic>Umbilical cord diameter</topic><topic>Wharton Jelly - growth & development</topic><topic>Wharton Jelly - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Proctor, L.K</creatorcontrib><creatorcontrib>Fitzgerald, B</creatorcontrib><creatorcontrib>Whittle, W.L</creatorcontrib><creatorcontrib>Mokhtari, N</creatorcontrib><creatorcontrib>Lee, E</creatorcontrib><creatorcontrib>Machin, G</creatorcontrib><creatorcontrib>Kingdom, J.C.P</creatorcontrib><creatorcontrib>Keating, S.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Proctor, L.K</au><au>Fitzgerald, B</au><au>Whittle, W.L</au><au>Mokhtari, N</au><au>Lee, E</au><au>Machin, G</au><au>Kingdom, J.C.P</au><au>Keating, S.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>34</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Objective The aims of this study were to develop a nomogram of umbilical cord diameter (UCD) for pathologic examination of the placenta, to identify the umbilical cord components responsible for variations in UCD, and to examine the relationship between UCD and other placental pathologic features and perinatal outcome. Study design We prospectively collected 497 umbilical cords between 18 and 41 weeks' gestation over a 1-year period. Fresh-tissue UCD were grouped according to gestational age and compared to sonographic and histological measurements. Associations between UCD percentile and placental pathologic findings or obstetrical outcomes were examined. Results Mean UCD increased with gestational age until a plateau at 1.0 cm in the third trimester, a value that was 0.56 cm less than sonographic measurements prior to delivery and 0.17 cm greater than UCD measured histologically. Umbilical cord components varied with UCD percentile, with umbilical vessel area increased in thick cords ( p < 0.001) and Wharton's jelly area reduced in thin cords ( p = 0.002). Thin umbilical cords were associated with at least one pathologic histological placental finding ( p = 0.02), low placental weight ( p < 0.001), single umbilical artery ( p = 0.02), marginal cord insertion ( p = 0.01), and low infant birth weight ( p < 0.001). Conclusions This study provides reference curves for post-delivery UCD from 18 to 41 weeks' gestation for use by perinatal pathologists. We show that increased UCD is a function of increased umbilical blood vessel volume and decreased UCD is a function of decreased Wharton's jelly volume. UCD shows a strong association with placental and infant birth weight.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23174148</pmid><doi>10.1016/j.placenta.2012.10.015</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-4004 |
| ispartof | Placenta (Eastbourne), 2013-01, Vol.34 (1), p.62-66 |
| issn | 0143-4004 1532-3102 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1273266742 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Birth weight Birth Weight - physiology Cohort Studies Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gestational Age Growth Charts Humans Infant, Newborn Internal Medicine Nomogram Obstetrics and Gynecology Organ Size Pathology Percentile curve Placenta Placenta Diseases - etiology Placenta Diseases - pathology Pregnancy Pregnancy Outcome Prognosis Umbilical Cord - anatomy & histology Umbilical Cord - growth & development Umbilical Cord - pathology Umbilical cord diameter Wharton Jelly - growth & development Wharton Jelly - pathology |
| title | Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T08%3A10%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Umbilical%20cord%20diameter%20percentile%20curves%20and%20their%20correlation%20to%20birth%20weight%20and%20placental%20pathology&rft.jtitle=Placenta%20(Eastbourne)&rft.au=Proctor,%20L.K&rft.date=2013-01-01&rft.volume=34&rft.issue=1&rft.spage=62&rft.epage=66&rft.pages=62-66&rft.issn=0143-4004&rft.eissn=1532-3102&rft.coden=PLACDF&rft_id=info:doi/10.1016/j.placenta.2012.10.015&rft_dat=%3Cproquest_cross%3E1273266742%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1273266742&rft_id=info:pmid/23174148&rft_els_id=1_s2_0_S0143400412004080&rfr_iscdi=true |