Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses
This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a cont...
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| Veröffentlicht in: | Letters in applied microbiology 2013-01, Vol.56 (1), p.14-20 |
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| creator | Sreenivasan, P.K. Haraszthy, V.I. Zambon, J.J. |
| description | This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a control fluoride mouthrinse without CPC. Two different approaches were used to evaluate antimicrobial activity. First, the minimum inhibitory concentration (MIC) was determined for each mouthrinse against a panel of 25 micro‐organisms including species associated with dental caries, gingivitis and periodontitis. Second, supragingival dental plaque obtained from 15 adults was incubated with the four mouthrinses to evaluate antimicrobial activity on micro‐organisms in oral biofilms. Both CPC mouthrinses exhibited lower MIC's, that is, greater antimicrobial activity, against oral Gram‐negative bacteria especially periodontal pathogens and species implicated in halitosis such as Aggregatibacter actinomycemcomitans, Campylobacter rectus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei than the control mouthrinse. Ex‐vivo tests on supragingival plaque micro‐organisms demonstrated significantly greater antimicrobial activity by the CPC mouthrinses (>90% killing, P 98% killing, P |
| doi_str_mv | 10.1111/lam.12008 |
| format | Article |
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Significance and Impact of Study
These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.
Significance and Impact of Study: These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.</description><identifier>ISSN: 0266-8254</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1111/lam.12008</identifier><identifier>PMID: 23039819</identifier><identifier>CODEN: LAMIE7</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; Anti-Bacterial Agents - pharmacology ; antimicrobial susceptibility ; Bacteria - classification ; Bacteria - drug effects ; Biofilms - drug effects ; Cetylpyridinium - pharmacology ; cetylpyridinium chloride ; chlorhexidine ; Chlorhexidine - pharmacology ; dental plaque ; Dental Plaque - microbiology ; Ethanol - pharmacology ; Fluorides - pharmacology ; Humans ; Microbial Sensitivity Tests ; Middle Aged ; mouthrinse ; Mouthwashes - pharmacology ; oral microbiology ; Young Adult</subject><ispartof>Letters in applied microbiology, 2013-01, Vol.56 (1), p.14-20</ispartof><rights>2012 The Society for Applied Microbiology</rights><rights>2012 The Society for Applied Microbiology.</rights><rights>Copyright © 2013 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3348-e8ca0d747e704698270e57238acd0c48cccdfe62f2e05a6f8f18e896008f20013</citedby><cites>FETCH-LOGICAL-c3348-e8ca0d747e704698270e57238acd0c48cccdfe62f2e05a6f8f18e896008f20013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Flam.12008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Flam.12008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23039819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sreenivasan, P.K.</creatorcontrib><creatorcontrib>Haraszthy, V.I.</creatorcontrib><creatorcontrib>Zambon, J.J.</creatorcontrib><title>Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a control fluoride mouthrinse without CPC. Two different approaches were used to evaluate antimicrobial activity. First, the minimum inhibitory concentration (MIC) was determined for each mouthrinse against a panel of 25 micro‐organisms including species associated with dental caries, gingivitis and periodontitis. Second, supragingival dental plaque obtained from 15 adults was incubated with the four mouthrinses to evaluate antimicrobial activity on micro‐organisms in oral biofilms. Both CPC mouthrinses exhibited lower MIC's, that is, greater antimicrobial activity, against oral Gram‐negative bacteria especially periodontal pathogens and species implicated in halitosis such as Aggregatibacter actinomycemcomitans, Campylobacter rectus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei than the control mouthrinse. Ex‐vivo tests on supragingival plaque micro‐organisms demonstrated significantly greater antimicrobial activity by the CPC mouthrinses (>90% killing, P < 0·001) and the chlorhexidine rinse (>98% killing, P < 0·05) compared to the control fluoride mouthrinse. Whilst the chlorhexidine mouthrinse was most effective, mouthrinses containing 0·05% CPC formulated with or without alcohol demonstrated broad‐spectrum antimicrobial activity against both laboratory strains and supragingival plaque bacteria compared to a control mouthrinse without CPC.
Significance and Impact of Study
These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.
Significance and Impact of Study: These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antimicrobial susceptibility</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Biofilms - drug effects</subject><subject>Cetylpyridinium - pharmacology</subject><subject>cetylpyridinium chloride</subject><subject>chlorhexidine</subject><subject>Chlorhexidine - pharmacology</subject><subject>dental plaque</subject><subject>Dental Plaque - microbiology</subject><subject>Ethanol - pharmacology</subject><subject>Fluorides - pharmacology</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>mouthrinse</subject><subject>Mouthwashes - pharmacology</subject><subject>oral microbiology</subject><subject>Young Adult</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUhgdRbL0sfAEJiKCLtHNJMpNlKfUCFTcK7obp5AydMklqJkHyZO59MkdTXQiezeHAx89_PoTOCJ6QMFOnygmhGIs9NCYJpzHP0pd9NMY0y2JB02SEjrzf4EAQmh-iEWWY5YLkY7SYVa0trW7qlVUuAmOsVrqPahPhj3ecXkYa2t5t-8YWtrJdGem1q8MBUVl37bqxlQd_gg6Mch5Od_sYPd8snuZ38fLx9n4-W8aasUTEILTCBU84cJxkuaAcQ8opE0oXWCdCa10YyKihgFOVGWGIAJFnobcJ7xF2jK6G3G1Tv3bgW1lar8E5VUHdeUkoZ-Hn4CKgF3_QTd01VWgXKJanKU9YHqjrgQoCvG_AyG1jS9X0kmD55VYGt_LbbWDPd4ndqoTil_yRGYDpALxZB_3_SXI5exgiPwHQM4IP</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Sreenivasan, P.K.</creator><creator>Haraszthy, V.I.</creator><creator>Zambon, J.J.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses</title><author>Sreenivasan, P.K. ; Haraszthy, V.I. ; Zambon, J.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3348-e8ca0d747e704698270e57238acd0c48cccdfe62f2e05a6f8f18e896008f20013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antimicrobial susceptibility</topic><topic>Bacteria - classification</topic><topic>Bacteria - drug effects</topic><topic>Biofilms - drug effects</topic><topic>Cetylpyridinium - pharmacology</topic><topic>cetylpyridinium chloride</topic><topic>chlorhexidine</topic><topic>Chlorhexidine - pharmacology</topic><topic>dental plaque</topic><topic>Dental Plaque - microbiology</topic><topic>Ethanol - pharmacology</topic><topic>Fluorides - pharmacology</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>mouthrinse</topic><topic>Mouthwashes - pharmacology</topic><topic>oral microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sreenivasan, P.K.</creatorcontrib><creatorcontrib>Haraszthy, V.I.</creatorcontrib><creatorcontrib>Zambon, J.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sreenivasan, P.K.</au><au>Haraszthy, V.I.</au><au>Zambon, J.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>56</volume><issue>1</issue><spage>14</spage><epage>20</epage><pages>14-20</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><coden>LAMIE7</coden><abstract>This study evaluated the antimicrobial activity of two commercially available 0·05% cetylpyridinium chloride (CPC) mouthrinses with or without alcohol and examined its antimicrobial activity on oral bacterial species including fresh clinical isolates compared to a chlorhexidine mouthrinse and a control fluoride mouthrinse without CPC. Two different approaches were used to evaluate antimicrobial activity. First, the minimum inhibitory concentration (MIC) was determined for each mouthrinse against a panel of 25 micro‐organisms including species associated with dental caries, gingivitis and periodontitis. Second, supragingival dental plaque obtained from 15 adults was incubated with the four mouthrinses to evaluate antimicrobial activity on micro‐organisms in oral biofilms. Both CPC mouthrinses exhibited lower MIC's, that is, greater antimicrobial activity, against oral Gram‐negative bacteria especially periodontal pathogens and species implicated in halitosis such as Aggregatibacter actinomycemcomitans, Campylobacter rectus, Eikenella corrodens, Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei than the control mouthrinse. Ex‐vivo tests on supragingival plaque micro‐organisms demonstrated significantly greater antimicrobial activity by the CPC mouthrinses (>90% killing, P < 0·001) and the chlorhexidine rinse (>98% killing, P < 0·05) compared to the control fluoride mouthrinse. Whilst the chlorhexidine mouthrinse was most effective, mouthrinses containing 0·05% CPC formulated with or without alcohol demonstrated broad‐spectrum antimicrobial activity against both laboratory strains and supragingival plaque bacteria compared to a control mouthrinse without CPC.
Significance and Impact of Study
These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.
Significance and Impact of Study: These in vitro and ex‐vivo studies provide a biological rationale for previous clinical studies demonstrating the efficacy of CPC mouthrinses in reducing supragingival plaque and plaque‐associated gingivitis.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>23039819</pmid><doi>10.1111/lam.12008</doi><tpages>7</tpages></addata></record> |
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| ispartof | Letters in applied microbiology, 2013-01, Vol.56 (1), p.14-20 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anti-Bacterial Agents - pharmacology antimicrobial susceptibility Bacteria - classification Bacteria - drug effects Biofilms - drug effects Cetylpyridinium - pharmacology cetylpyridinium chloride chlorhexidine Chlorhexidine - pharmacology dental plaque Dental Plaque - microbiology Ethanol - pharmacology Fluorides - pharmacology Humans Microbial Sensitivity Tests Middle Aged mouthrinse Mouthwashes - pharmacology oral microbiology Young Adult |
| title | Antimicrobial efficacy of 0·05% cetylpyridinium chloride mouthrinses |
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