Value of a short four-joint ultrasound test for gout diagnosis: a pilot study
The goal of this study was to investigate the usefulness of a short ultrasound (US) assessment in gout. Patients with gout, confirmed by urate crystal identification, and having at least one symptomatic flare in the last three months were included. Standardised US examinations of sixteen joints and...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2012-11, Vol.30 (6), p.830-837 |
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| creator | PEITEADO, D DE MIGUEL, E VILLALBA, A ORDONEZ, M. C CASTILLO, C MARTIN-MOLA, E |
| description | The goal of this study was to investigate the usefulness of a short ultrasound (US) assessment in gout.
Patients with gout, confirmed by urate crystal identification, and having at least one symptomatic flare in the last three months were included. Standardised US examinations of sixteen joints and eight tendons in the lower limbs were carried out. Six lesions were studied: hyperechoic spots in the synovial fluid, hyperechoic cloudy areas (HCA), bright stippled aggregates (BSA), the double contour sign (DCS), erosions and the Doppler signal. For reliability, inter-reader analyses were performed by five rheumatologists. With the results, a short US assessment was created.
Twenty-nine consecutive patients were included (93% men). The Doppler signal, HCAs and BSAs appeared in 100%, 97% and 93% of the patients, respectively. The DCS was found in 69% of patients. The locations that were most affected were the first metatarsophalangeal joint (MTP) and the knee joints, both of which are in 93% of patients. Reliability analyses showed consistent results for erosions, the Doppler signal, HCAs and the DCS in the 1st MTP (k=0.818, k=0.958, k=0.739 and k= 0.697, respectively) and for the DCS in the knees (k=0.779). A six-minute US examination of four joints (knees and the 1st MTPs) detected HCAs or DCS in 97% of cases.
A US examination of four joints for two elemental lesions (the DCS and HCAs) is feasible, reliable and has face and content validity as a diagnostic test in patients with crystal-proven gout. |
| format | Article |
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Patients with gout, confirmed by urate crystal identification, and having at least one symptomatic flare in the last three months were included. Standardised US examinations of sixteen joints and eight tendons in the lower limbs were carried out. Six lesions were studied: hyperechoic spots in the synovial fluid, hyperechoic cloudy areas (HCA), bright stippled aggregates (BSA), the double contour sign (DCS), erosions and the Doppler signal. For reliability, inter-reader analyses were performed by five rheumatologists. With the results, a short US assessment was created.
Twenty-nine consecutive patients were included (93% men). The Doppler signal, HCAs and BSAs appeared in 100%, 97% and 93% of the patients, respectively. The DCS was found in 69% of patients. The locations that were most affected were the first metatarsophalangeal joint (MTP) and the knee joints, both of which are in 93% of patients. Reliability analyses showed consistent results for erosions, the Doppler signal, HCAs and the DCS in the 1st MTP (k=0.818, k=0.958, k=0.739 and k= 0.697, respectively) and for the DCS in the knees (k=0.779). A six-minute US examination of four joints (knees and the 1st MTPs) detected HCAs or DCS in 97% of cases.
A US examination of four joints for two elemental lesions (the DCS and HCAs) is feasible, reliable and has face and content validity as a diagnostic test in patients with crystal-proven gout.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 23020889</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Diseases of the osteoarticular system ; Feasibility Studies ; Female ; Gout - diagnostic imaging ; Gout - pathology ; Humans ; Inflammatory joint diseases ; Knee Joint - diagnostic imaging ; Knee Joint - pathology ; Male ; Medical sciences ; Metabolic diseases ; Metatarsophalangeal Joint - diagnostic imaging ; Metatarsophalangeal Joint - pathology ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Observer Variation ; Other metabolic disorders ; Pilot Projects ; Predictive Value of Tests ; Purines and pyrimidines (gout, hyperuricemia...) ; Reproducibility of Results ; Ultrasonography, Doppler</subject><ispartof>Clinical and experimental rheumatology, 2012-11, Vol.30 (6), p.830-837</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26853203$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23020889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PEITEADO, D</creatorcontrib><creatorcontrib>DE MIGUEL, E</creatorcontrib><creatorcontrib>VILLALBA, A</creatorcontrib><creatorcontrib>ORDONEZ, M. C</creatorcontrib><creatorcontrib>CASTILLO, C</creatorcontrib><creatorcontrib>MARTIN-MOLA, E</creatorcontrib><title>Value of a short four-joint ultrasound test for gout diagnosis: a pilot study</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>The goal of this study was to investigate the usefulness of a short ultrasound (US) assessment in gout.
Patients with gout, confirmed by urate crystal identification, and having at least one symptomatic flare in the last three months were included. Standardised US examinations of sixteen joints and eight tendons in the lower limbs were carried out. Six lesions were studied: hyperechoic spots in the synovial fluid, hyperechoic cloudy areas (HCA), bright stippled aggregates (BSA), the double contour sign (DCS), erosions and the Doppler signal. For reliability, inter-reader analyses were performed by five rheumatologists. With the results, a short US assessment was created.
Twenty-nine consecutive patients were included (93% men). The Doppler signal, HCAs and BSAs appeared in 100%, 97% and 93% of the patients, respectively. The DCS was found in 69% of patients. The locations that were most affected were the first metatarsophalangeal joint (MTP) and the knee joints, both of which are in 93% of patients. Reliability analyses showed consistent results for erosions, the Doppler signal, HCAs and the DCS in the 1st MTP (k=0.818, k=0.958, k=0.739 and k= 0.697, respectively) and for the DCS in the knees (k=0.779). A six-minute US examination of four joints (knees and the 1st MTPs) detected HCAs or DCS in 97% of cases.
A US examination of four joints for two elemental lesions (the DCS and HCAs) is feasible, reliable and has face and content validity as a diagnostic test in patients with crystal-proven gout.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Gout - diagnostic imaging</subject><subject>Gout - pathology</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metatarsophalangeal Joint - diagnostic imaging</subject><subject>Metatarsophalangeal Joint - pathology</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Observer Variation</subject><subject>Other metabolic disorders</subject><subject>Pilot Projects</subject><subject>Predictive Value of Tests</subject><subject>Purines and pyrimidines (gout, hyperuricemia...)</subject><subject>Reproducibility of Results</subject><subject>Ultrasonography, Doppler</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MtKAzEUBuAgiq3VV5BsBDcDuc5k3EnRKlTcqHQ3JJOkpqSTMZdF394RK67O4v_-w-GcgDnmLa1QKzanYI5oSyrB680MXKS0Q4jUvG7OwYxQRJAQ7Ry8fEhfDAwWSpg-Q8zQhhKrXXBDhsXnKFMog4bZpJ8owm0oGWont0NILt1NtdH5kGHKRR8uwZmVPpmr41yA98eHt-VTtX5dPS_v19VIGM4VVkYpjHujJaPastogJrisqVFNM2XWII3rRmDRW0s0V5KwiQrWK2Vty-kC3P7uHWP4KtNp3d6l3ngvBxNK6jBpKMEta8lEr4-0qL3R3RjdXsZD9_eCCdwcgUy99DbKoXfp39WCU4Io_QacZmc5</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>PEITEADO, D</creator><creator>DE MIGUEL, E</creator><creator>VILLALBA, A</creator><creator>ORDONEZ, M. C</creator><creator>CASTILLO, C</creator><creator>MARTIN-MOLA, E</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Value of a short four-joint ultrasound test for gout diagnosis: a pilot study</title><author>PEITEADO, D ; DE MIGUEL, E ; VILLALBA, A ; ORDONEZ, M. C ; CASTILLO, C ; MARTIN-MOLA, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p241t-1bebb11ceda43df46e0485a63eb77bebfe0d167818cff2d5ba24da484cbbff953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gout - diagnostic imaging</topic><topic>Gout - pathology</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metatarsophalangeal Joint - diagnostic imaging</topic><topic>Metatarsophalangeal Joint - pathology</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Observer Variation</topic><topic>Other metabolic disorders</topic><topic>Pilot Projects</topic><topic>Predictive Value of Tests</topic><topic>Purines and pyrimidines (gout, hyperuricemia...)</topic><topic>Reproducibility of Results</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEITEADO, D</creatorcontrib><creatorcontrib>DE MIGUEL, E</creatorcontrib><creatorcontrib>VILLALBA, A</creatorcontrib><creatorcontrib>ORDONEZ, M. C</creatorcontrib><creatorcontrib>CASTILLO, C</creatorcontrib><creatorcontrib>MARTIN-MOLA, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEITEADO, D</au><au>DE MIGUEL, E</au><au>VILLALBA, A</au><au>ORDONEZ, M. C</au><au>CASTILLO, C</au><au>MARTIN-MOLA, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of a short four-joint ultrasound test for gout diagnosis: a pilot study</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>30</volume><issue>6</issue><spage>830</spage><epage>837</epage><pages>830-837</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>The goal of this study was to investigate the usefulness of a short ultrasound (US) assessment in gout.
Patients with gout, confirmed by urate crystal identification, and having at least one symptomatic flare in the last three months were included. Standardised US examinations of sixteen joints and eight tendons in the lower limbs were carried out. Six lesions were studied: hyperechoic spots in the synovial fluid, hyperechoic cloudy areas (HCA), bright stippled aggregates (BSA), the double contour sign (DCS), erosions and the Doppler signal. For reliability, inter-reader analyses were performed by five rheumatologists. With the results, a short US assessment was created.
Twenty-nine consecutive patients were included (93% men). The Doppler signal, HCAs and BSAs appeared in 100%, 97% and 93% of the patients, respectively. The DCS was found in 69% of patients. The locations that were most affected were the first metatarsophalangeal joint (MTP) and the knee joints, both of which are in 93% of patients. Reliability analyses showed consistent results for erosions, the Doppler signal, HCAs and the DCS in the 1st MTP (k=0.818, k=0.958, k=0.739 and k= 0.697, respectively) and for the DCS in the knees (k=0.779). A six-minute US examination of four joints (knees and the 1st MTPs) detected HCAs or DCS in 97% of cases.
A US examination of four joints for two elemental lesions (the DCS and HCAs) is feasible, reliable and has face and content validity as a diagnostic test in patients with crystal-proven gout.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>23020889</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Diseases of the osteoarticular system Feasibility Studies Female Gout - diagnostic imaging Gout - pathology Humans Inflammatory joint diseases Knee Joint - diagnostic imaging Knee Joint - pathology Male Medical sciences Metabolic diseases Metatarsophalangeal Joint - diagnostic imaging Metatarsophalangeal Joint - pathology Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Observer Variation Other metabolic disorders Pilot Projects Predictive Value of Tests Purines and pyrimidines (gout, hyperuricemia...) Reproducibility of Results Ultrasonography, Doppler |
| title | Value of a short four-joint ultrasound test for gout diagnosis: a pilot study |
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