Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis
Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of T...
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Veröffentlicht in: | Archives of Dermatological Research 2013, Vol.305 (1), p.59-67 |
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description | Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of TLR3, 4, 7 and 9 were analyzed in tumors from 30 patients with CMM. The analysis was performed by immunohistochemistry, and the results were correlated with various clinicopathological findings and with relapse-free survival. Our results indicate that there was a wide variability in the immunostaining score values for each receptor. Positive staining for TLRs was generally found in tumor cells, especially for TLR4 and TLR9. Nevertheless, a significant percentage of tumors also showed TLR4 expression in mononuclear inflammatory cells (62.1 %) and in fibroblast-like cells (34.5 %). Our results showed no significant association between score values for each TLR and clinicopathological characteristics of patients. However, our results demonstrated that high TLR4 expression was significantly associated with a shortened relapse-free survival (
p
= 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma. |
doi_str_mv | 10.1007/s00403-012-1300-y |
format | Article |
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p
= 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-012-1300-y</identifier><identifier>PMID: 23179584</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Chi-Square Distribution ; Dermatology ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Inflammation ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Melanoma ; Melanoma - immunology ; Melanoma - mortality ; Melanoma - pathology ; Melanoma - therapy ; Middle Aged ; Original Paper ; Skin cancer ; Skin Neoplasms - immunology ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy ; Time Factors ; TLR3 protein ; TLR4 protein ; TLR9 protein ; Toll-Like Receptor 3 - analysis ; Toll-Like Receptor 4 - analysis ; Toll-Like Receptor 7 - analysis ; Toll-Like Receptor 8 - analysis ; Toll-like receptors ; Treatment Outcome ; Tumor cells ; Tumors ; Up-Regulation ; Young Adult</subject><ispartof>Archives of Dermatological Research, 2013, Vol.305 (1), p.59-67</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>Archives of Dermatological Research is a copyright of Springer, (2012). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-942107df14a095675cf1a56c29541833c412294a678d4928ba259dde8fa7db1d3</citedby><cites>FETCH-LOGICAL-c372t-942107df14a095675cf1a56c29541833c412294a678d4928ba259dde8fa7db1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-012-1300-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-012-1300-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23179584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eiró, N.</creatorcontrib><creatorcontrib>Ovies, C.</creatorcontrib><creatorcontrib>Fernandez-Garcia, B.</creatorcontrib><creatorcontrib>Álvarez-Cuesta, C. C.</creatorcontrib><creatorcontrib>González, L.</creatorcontrib><creatorcontrib>González, L. O.</creatorcontrib><creatorcontrib>Vizoso, F. J.</creatorcontrib><title>Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of TLR3, 4, 7 and 9 were analyzed in tumors from 30 patients with CMM. The analysis was performed by immunohistochemistry, and the results were correlated with various clinicopathological findings and with relapse-free survival. Our results indicate that there was a wide variability in the immunostaining score values for each receptor. Positive staining for TLRs was generally found in tumor cells, especially for TLR4 and TLR9. Nevertheless, a significant percentage of tumors also showed TLR4 expression in mononuclear inflammatory cells (62.1 %) and in fibroblast-like cells (34.5 %). Our results showed no significant association between score values for each TLR and clinicopathological characteristics of patients. However, our results demonstrated that high TLR4 expression was significantly associated with a shortened relapse-free survival (
p
= 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Chi-Square Distribution</subject><subject>Dermatology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Melanoma - immunology</subject><subject>Melanoma - mortality</subject><subject>Melanoma - pathology</subject><subject>Melanoma - therapy</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - immunology</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><subject>Time Factors</subject><subject>TLR3 protein</subject><subject>TLR4 protein</subject><subject>TLR9 protein</subject><subject>Toll-Like Receptor 3 - analysis</subject><subject>Toll-Like Receptor 4 - analysis</subject><subject>Toll-Like Receptor 7 - analysis</subject><subject>Toll-Like Receptor 8 - analysis</subject><subject>Toll-like receptors</subject><subject>Treatment Outcome</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Up-Regulation</subject><subject>Young Adult</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1rFTEUhoMo9lL7A9xIwI2Ljp58TDJxJ6V-wAWhtOAu5GYy96bMJGOSQe-6f9zUqRYEs0kgz_uehAehlwTeEgD5LgNwYA0Q2hAG0ByfoA3hjDYg1LenaAOMQ8OEEifoLOdbqEsCpyCfoxPKiFRtxzfo7vLnnFzOPgYcB3y9vWLnmJ9jiU3oscI-YLsUE1xcMp7M6PfBhIInN5oQJ_Mep3oqNZ0PfsY_fDlgO_rgbZxNOcQx7r01I7YHk4wtLvlcvM2_y-cU9yFmn1-gZ4MZszt72E_RzcfL64vPzfbrpy8XH7aNZZKWRnFKQPYD4QZUK2RrB2JaYalqOekYs5xQqrgRsuu5ot3O0Fb1vesGI_sd6dkperP21snfF5eLnny2bhzX72lCJSOtEERW9PU_6G1cUqiv05R2IGjXCVUpslI2xZyTG_Sc_GTSURPQ95L0KklXSfpekj7WzKuH5mU3uf5v4o-SCtAVyPUq7F16HP3_1l_1vpya</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Eiró, N.</creator><creator>Ovies, C.</creator><creator>Fernandez-Garcia, B.</creator><creator>Álvarez-Cuesta, C. 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C.</au><au>González, L.</au><au>González, L. O.</au><au>Vizoso, F. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2013</date><risdate>2013</risdate><volume>305</volume><issue>1</issue><spage>59</spage><epage>67</epage><pages>59-67</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of TLR3, 4, 7 and 9 were analyzed in tumors from 30 patients with CMM. The analysis was performed by immunohistochemistry, and the results were correlated with various clinicopathological findings and with relapse-free survival. Our results indicate that there was a wide variability in the immunostaining score values for each receptor. Positive staining for TLRs was generally found in tumor cells, especially for TLR4 and TLR9. Nevertheless, a significant percentage of tumors also showed TLR4 expression in mononuclear inflammatory cells (62.1 %) and in fibroblast-like cells (34.5 %). Our results showed no significant association between score values for each TLR and clinicopathological characteristics of patients. However, our results demonstrated that high TLR4 expression was significantly associated with a shortened relapse-free survival (
p
= 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23179584</pmid><doi>10.1007/s00403-012-1300-y</doi><tpages>9</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Chi-Square Distribution Dermatology Disease-Free Survival Female Humans Immunohistochemistry Inflammation Kaplan-Meier Estimate Male Medical prognosis Medicine Medicine & Public Health Melanoma Melanoma - immunology Melanoma - mortality Melanoma - pathology Melanoma - therapy Middle Aged Original Paper Skin cancer Skin Neoplasms - immunology Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - therapy Time Factors TLR3 protein TLR4 protein TLR9 protein Toll-Like Receptor 3 - analysis Toll-Like Receptor 4 - analysis Toll-Like Receptor 7 - analysis Toll-Like Receptor 8 - analysis Toll-like receptors Treatment Outcome Tumor cells Tumors Up-Regulation Young Adult |
title | Expression of TLR3, 4, 7 and 9 in cutaneous malignant melanoma: relationship with clinicopathological characteristics and prognosis |
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