Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report

Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcho...

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Veröffentlicht in:Psychogeriatrics 2012-12, Vol.12 (4), p.255-258
Hauptverfasser: OZAKI, Asami, NISHIDA, Masaki, KOYAMA, Keiko, ISHIKAWA, Kinya, NISHIKAWA, Toru
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container_end_page 258
container_issue 4
container_start_page 255
container_title Psychogeriatrics
container_volume 12
creator OZAKI, Asami
NISHIDA, Masaki
KOYAMA, Keiko
ISHIKAWA, Kinya
NISHIKAWA, Toru
description Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.
doi_str_mv 10.1111/j.1479-8301.2012.00411.x
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source MEDLINE; Wiley Online Library All Journals
subjects acetylcholine
Aged, 80 and over
Cholinesterase Inhibitors - administration & dosage
Cholinesterase Inhibitors - therapeutic use
Cognition - drug effects
Dementia
DLB
donepezil
Eye movements
Female
Geriatric psychology
Humans
Indans - administration & dosage
Indans - therapeutic use
Lewy Body Disease - diagnosis
Lewy Body Disease - drug therapy
Piperidines - administration & dosage
Piperidines - therapeutic use
Polysomnography
Psychiatric Status Rating Scales
REM Sleep Behavior Disorder - chemically induced
Sleep disorders
sleep spindle
Sleep, REM - drug effects
Treatment Outcome
title Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report
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