Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report
Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcho...
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Veröffentlicht in: | Psychogeriatrics 2012-12, Vol.12 (4), p.255-258 |
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creator | OZAKI, Asami NISHIDA, Masaki KOYAMA, Keiko ISHIKAWA, Kinya NISHIKAWA, Toru |
description | Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient. |
doi_str_mv | 10.1111/j.1479-8301.2012.00411.x |
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Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.</description><identifier>ISSN: 1346-3500</identifier><identifier>EISSN: 1479-8301</identifier><identifier>DOI: 10.1111/j.1479-8301.2012.00411.x</identifier><identifier>PMID: 23279148</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>acetylcholine ; Aged, 80 and over ; Cholinesterase Inhibitors - administration & dosage ; Cholinesterase Inhibitors - therapeutic use ; Cognition - drug effects ; Dementia ; DLB ; donepezil ; Eye movements ; Female ; Geriatric psychology ; Humans ; Indans - administration & dosage ; Indans - therapeutic use ; Lewy Body Disease - diagnosis ; Lewy Body Disease - drug therapy ; Piperidines - administration & dosage ; Piperidines - therapeutic use ; Polysomnography ; Psychiatric Status Rating Scales ; REM Sleep Behavior Disorder - chemically induced ; Sleep disorders ; sleep spindle ; Sleep, REM - drug effects ; Treatment Outcome</subject><ispartof>Psychogeriatrics, 2012-12, Vol.12 (4), p.255-258</ispartof><rights>2012 The Authors. Psychogeriatrics © 2012 Japanese Psychogeriatric Society</rights><rights>2012 The Authors. Psychogeriatrics © 2012 Japanese Psychogeriatric Society.</rights><rights>Psychogeriatrics © 2012 The Japanese Psychogeriatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4541-dab38ea32e99fe0fc4989c364c8b4b51980fb1278619585daf8e777f0064856b3</citedby><cites>FETCH-LOGICAL-c4541-dab38ea32e99fe0fc4989c364c8b4b51980fb1278619585daf8e777f0064856b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1479-8301.2012.00411.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1479-8301.2012.00411.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23279148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OZAKI, Asami</creatorcontrib><creatorcontrib>NISHIDA, Masaki</creatorcontrib><creatorcontrib>KOYAMA, Keiko</creatorcontrib><creatorcontrib>ISHIKAWA, Kinya</creatorcontrib><creatorcontrib>NISHIKAWA, Toru</creatorcontrib><title>Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report</title><title>Psychogeriatrics</title><addtitle>Psychogeriatrics</addtitle><description>Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.</description><subject>acetylcholine</subject><subject>Aged, 80 and over</subject><subject>Cholinesterase Inhibitors - administration & dosage</subject><subject>Cholinesterase Inhibitors - therapeutic use</subject><subject>Cognition - drug effects</subject><subject>Dementia</subject><subject>DLB</subject><subject>donepezil</subject><subject>Eye movements</subject><subject>Female</subject><subject>Geriatric psychology</subject><subject>Humans</subject><subject>Indans - administration & dosage</subject><subject>Indans - therapeutic use</subject><subject>Lewy Body Disease - diagnosis</subject><subject>Lewy Body Disease - drug therapy</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - therapeutic use</subject><subject>Polysomnography</subject><subject>Psychiatric Status Rating Scales</subject><subject>REM Sleep Behavior Disorder - chemically induced</subject><subject>Sleep disorders</subject><subject>sleep spindle</subject><subject>Sleep, REM - drug effects</subject><subject>Treatment Outcome</subject><issn>1346-3500</issn><issn>1479-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctKxDAUhoMo3l9BAm7ctObaJoILGa8woKAuBCGk7Slm6LS1aRnHlY_gM_okZhx14cps8h_ynXMIH0KYkpiGcziJqUh1pDihMSOUxYQISuOXFbT5-7AaMhdJxCUhG2jL-wkhTEjO19EG4yzVVKhN9Hja1NDCq6s-3t5dXQw5FNhXAC32bagrwK7GFre2d1D3eOb6J1zANGRnl9UYZnOcNYUDfxTI3HrAHbRN1--gtdJWHna_7210f352N7qMxtcXV6OTcZQLKWhU2IwrsJyB1iWQMhda6ZwnIleZyCTVipQZZalKqJZKFrZUkKZpSUgilEwyvo0OlnPbrnkewPdm6nwOVWVraAZvQi-nTAmR_AdlqUgFJQHd_4NOmqGrw0cCJaXmVHMZKLWk8q7xvoPStJ2b2m5uKDELWWZiFk7MwolZyDJfssxLaN37XjBkUyh-G3_sBOB4CcxcBfN_DzY3tw8XIfFPB7qh0A</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>OZAKI, Asami</creator><creator>NISHIDA, Masaki</creator><creator>KOYAMA, Keiko</creator><creator>ISHIKAWA, Kinya</creator><creator>NISHIKAWA, Toru</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report</title><author>OZAKI, Asami ; NISHIDA, Masaki ; KOYAMA, Keiko ; ISHIKAWA, Kinya ; NISHIKAWA, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4541-dab38ea32e99fe0fc4989c364c8b4b51980fb1278619585daf8e777f0064856b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>acetylcholine</topic><topic>Aged, 80 and over</topic><topic>Cholinesterase Inhibitors - administration & dosage</topic><topic>Cholinesterase Inhibitors - therapeutic use</topic><topic>Cognition - drug effects</topic><topic>Dementia</topic><topic>DLB</topic><topic>donepezil</topic><topic>Eye movements</topic><topic>Female</topic><topic>Geriatric psychology</topic><topic>Humans</topic><topic>Indans - administration & dosage</topic><topic>Indans - therapeutic use</topic><topic>Lewy Body Disease - diagnosis</topic><topic>Lewy Body Disease - drug therapy</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - therapeutic use</topic><topic>Polysomnography</topic><topic>Psychiatric Status Rating Scales</topic><topic>REM Sleep Behavior Disorder - chemically induced</topic><topic>Sleep disorders</topic><topic>sleep spindle</topic><topic>Sleep, REM - drug effects</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OZAKI, Asami</creatorcontrib><creatorcontrib>NISHIDA, Masaki</creatorcontrib><creatorcontrib>KOYAMA, Keiko</creatorcontrib><creatorcontrib>ISHIKAWA, Kinya</creatorcontrib><creatorcontrib>NISHIKAWA, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychogeriatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OZAKI, Asami</au><au>NISHIDA, Masaki</au><au>KOYAMA, Keiko</au><au>ISHIKAWA, Kinya</au><au>NISHIKAWA, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report</atitle><jtitle>Psychogeriatrics</jtitle><addtitle>Psychogeriatrics</addtitle><date>2012-12</date><risdate>2012</risdate><volume>12</volume><issue>4</issue><spage>255</spage><epage>258</epage><pages>255-258</pages><issn>1346-3500</issn><eissn>1479-8301</eissn><abstract>Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow‐wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>23279148</pmid><doi>10.1111/j.1479-8301.2012.00411.x</doi><tpages>4</tpages></addata></record> |
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subjects | acetylcholine Aged, 80 and over Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - therapeutic use Cognition - drug effects Dementia DLB donepezil Eye movements Female Geriatric psychology Humans Indans - administration & dosage Indans - therapeutic use Lewy Body Disease - diagnosis Lewy Body Disease - drug therapy Piperidines - administration & dosage Piperidines - therapeutic use Polysomnography Psychiatric Status Rating Scales REM Sleep Behavior Disorder - chemically induced Sleep disorders sleep spindle Sleep, REM - drug effects Treatment Outcome |
title | Donepezil‐induced sleep spindle in a patient with dementia with Lewy bodies: a case report |
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