Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?
Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous...
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| Veröffentlicht in: | International journal of dermatology 2013-01, Vol.52 (1), p.93-95 |
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| creator | Gomez-Moyano, Elisabeth Vera-Casaño, Ángel Sanz-Trelles, Andrés Martinez, Leandro |
| description | Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented.
Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation.
Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow‐up, there were no signs of local recurrence or metastases.
Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor. |
| doi_str_mv | 10.1111/j.1365-4632.2012.05675.x |
| format | Article |
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Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation.
Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow‐up, there were no signs of local recurrence or metastases.
Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/j.1365-4632.2012.05675.x</identifier><identifier>PMID: 23278615</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged, 80 and over ; Carcinoma, Merkel Cell - pathology ; Humans ; Male ; Prognosis ; Skin Neoplasms - pathology</subject><ispartof>International journal of dermatology, 2013-01, Vol.52 (1), p.93-95</ispartof><rights>2013 The International Society of Dermatology</rights><rights>2013 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4075-400b8ac4b179e1123f355c5dbcc61e93a3e2e370254d1f095b8a97c20215ae5b3</citedby><cites>FETCH-LOGICAL-c4075-400b8ac4b179e1123f355c5dbcc61e93a3e2e370254d1f095b8a97c20215ae5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-4632.2012.05675.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-4632.2012.05675.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23278615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez-Moyano, Elisabeth</creatorcontrib><creatorcontrib>Vera-Casaño, Ángel</creatorcontrib><creatorcontrib>Sanz-Trelles, Andrés</creatorcontrib><creatorcontrib>Martinez, Leandro</creatorcontrib><title>Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented.
Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation.
Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow‐up, there were no signs of local recurrence or metastases.
Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor.</description><subject>Aged, 80 and over</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Prognosis</subject><subject>Skin Neoplasms - pathology</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFFPIyEUhYlZo131Lxge92VGLgwzHROz2VTtaqomRuMjYegdpbZDBRrrv19mq32WB7g3nHM5fIRQYDmkdTLLQZQyK0rBc86A50yWlczXO2SwvfhBBowBZDWT9T75GcIstYJDsUf2ueDVsAQ5IE836F9xTg3O06a9sZ1baPpu4wsNqU1NdKtAp7Zt0WMXrY7WdafUBmoj1XTpnKdL7547F6I1tNUmOv_7kOy2eh7w6PM8II-XFw-jv9nkbnw1-jPJTMGqFJSxZqhN0UBVIwAXrZDSyGljTAlYCy2Qo6gYl8UUWlbLpK4rwxkHqVE24oD82sxNEd5WGKJa2NB_RneYcivglQDOoWZJOtxIjXcheGzV0tuF9h8KmOqxqpnq6amenuqxqv9Y1TpZjz9fWTULnG6NXxyT4GwjeLdz_Pj2YHV1fd5XyZ9t_DZEXG_92r-qshJJ-nQ7VpPy-nwyHt-rUvwDOf6VKA</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Gomez-Moyano, Elisabeth</creator><creator>Vera-Casaño, Ángel</creator><creator>Sanz-Trelles, Andrés</creator><creator>Martinez, Leandro</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?</title><author>Gomez-Moyano, Elisabeth ; Vera-Casaño, Ángel ; Sanz-Trelles, Andrés ; Martinez, Leandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4075-400b8ac4b179e1123f355c5dbcc61e93a3e2e370254d1f095b8a97c20215ae5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged, 80 and over</topic><topic>Carcinoma, Merkel Cell - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Prognosis</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez-Moyano, Elisabeth</creatorcontrib><creatorcontrib>Vera-Casaño, Ángel</creatorcontrib><creatorcontrib>Sanz-Trelles, Andrés</creatorcontrib><creatorcontrib>Martinez, Leandro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez-Moyano, Elisabeth</au><au>Vera-Casaño, Ángel</au><au>Sanz-Trelles, Andrés</au><au>Martinez, Leandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor?</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>52</volume><issue>1</issue><spage>93</spage><epage>95</epage><pages>93-95</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background Poor prognostic factors in Merkel cell carcinoma include male sex, advanced stage at diagnosis, large tumor size (>5 mm), diffuse growth pattern, heavy lymphocytic infiltrate, and high mitotic rate. To date only six cases of Merkel cell carcinoma with sarcomatous or pseudosarcomatous differentiation and poor prognosis have been documented.
Methods We present a new case of Merkel cell carcinoma with sarcomatous differentiation.
Results The immunohistochemical staining patterns reflected the morphologic differentiation of the epithelial and sarcomatous pattern. After two months of follow‐up, there were no signs of local recurrence or metastases.
Conclusion In all cases of merkelomas with sarcomatous differentiation described to date, lymph node metastases have been found, except in the presented case. However, larger series of cases will be required to determine if sarcomatous differentiation represents another negative prognostic factor.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23278615</pmid><doi>10.1111/j.1365-4632.2012.05675.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2013-01, Vol.52 (1), p.93-95 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged, 80 and over Carcinoma, Merkel Cell - pathology Humans Male Prognosis Skin Neoplasms - pathology |
| title | Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor? |
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