Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica
Pesticides have been associated with Parkinson's disease (PD) in many studies, and with Alzheimer's disease (AD) in a few. We conducted screening tests for neurologic disease and occupational pesticide use in a population-based sample of 400 elderly subjects at two government-run clinics i...
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| Veröffentlicht in: | Environmental research 2013, Vol.120, p.96-101 |
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| description | Pesticides have been associated with Parkinson's disease (PD) in many studies, and with Alzheimer's disease (AD) in a few.
We conducted screening tests for neurologic disease and occupational pesticide use in a population-based sample of 400 elderly subjects at two government-run clinics in Costa Rica; 361 subjects who failed the initial screen were given both the Mini-mental States Exam (MMSE) and a modified version of a 10-item United Parkinson's Disease Rating Motor Subscale (UPDRS). Among subjects who failed either test, 144 were then examined by a neurologist.
Past occupational pesticide exposure was reported by 18% of subjects. Exposed subjects performed worse on the MMSE than the non-exposed (mean 24.5 versus 25.9, p=0.01, adjusted for age, sex, and education). The exposed had significantly elevated risks of abnormal scores on two UPDRS items, tremor-at-rest (OR 2.58, 1.28–5.23), and finger-tapping (OR=2.94, 95% CI 1.03–8.41). Thirty-three (23%) of those examined by the neurologist were diagnosed with possible/probable PD, 3–4 times the expected based on international data; 85% of these cases had not been previously diagnosed. Among subjects who took the UPDRS, the exposed had an increased risk of PD (OR=2.57, 95% CI 0.91–7.26). No excess risk was found for a diagnosis of AD or mild cognitive impairment.
Elderly subjects with past occupational pesticide exposure performed significantly worse on screening tests for dementia and PD, and had an increased risk of an eventual PD diagnosis. Screening may be particularly appropriate among elderly subjects with past pesticide exposure.
► We screened 400 elderly subjects for neurologic disease and pesticide exposure in Costa Rica in 2 government clinics. ► Those with self-reported past occupational pesticide exposure performed significantly worse on cognitive and motor tests. ► Those reporting past occupational pesticide exposure had an odds ratio of 2.57 (0.91–7.26) for Parkinson's disease. ► Prevalence of Parkinson's disease was 3–4 times the expected in this population. ► Screening for neurologic disease may be particularly appropriate for those with past pesticide exposure. |
| doi_str_mv | 10.1016/j.envres.2012.08.014 |
| format | Article |
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We conducted screening tests for neurologic disease and occupational pesticide use in a population-based sample of 400 elderly subjects at two government-run clinics in Costa Rica; 361 subjects who failed the initial screen were given both the Mini-mental States Exam (MMSE) and a modified version of a 10-item United Parkinson's Disease Rating Motor Subscale (UPDRS). Among subjects who failed either test, 144 were then examined by a neurologist.
Past occupational pesticide exposure was reported by 18% of subjects. Exposed subjects performed worse on the MMSE than the non-exposed (mean 24.5 versus 25.9, p=0.01, adjusted for age, sex, and education). The exposed had significantly elevated risks of abnormal scores on two UPDRS items, tremor-at-rest (OR 2.58, 1.28–5.23), and finger-tapping (OR=2.94, 95% CI 1.03–8.41). Thirty-three (23%) of those examined by the neurologist were diagnosed with possible/probable PD, 3–4 times the expected based on international data; 85% of these cases had not been previously diagnosed. Among subjects who took the UPDRS, the exposed had an increased risk of PD (OR=2.57, 95% CI 0.91–7.26). No excess risk was found for a diagnosis of AD or mild cognitive impairment.
Elderly subjects with past occupational pesticide exposure performed significantly worse on screening tests for dementia and PD, and had an increased risk of an eventual PD diagnosis. Screening may be particularly appropriate among elderly subjects with past pesticide exposure.
► We screened 400 elderly subjects for neurologic disease and pesticide exposure in Costa Rica in 2 government clinics. ► Those with self-reported past occupational pesticide exposure performed significantly worse on cognitive and motor tests. ► Those reporting past occupational pesticide exposure had an odds ratio of 2.57 (0.91–7.26) for Parkinson's disease. ► Prevalence of Parkinson's disease was 3–4 times the expected in this population. ► Screening for neurologic disease may be particularly appropriate for those with past pesticide exposure.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2012.08.014</identifier><identifier>PMID: 23092715</identifier><identifier>CODEN: ENVRAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Biological and medical sciences ; Costa Rica - epidemiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia - diagnosis ; Dementia - epidemiology ; Dementia - etiology ; Female ; Geriatrics ; Humans ; Logistic Models ; Male ; Mass Screening ; Medical sciences ; Mild cognitive impairment ; Neurology ; Occupation ; Occupational Exposure - adverse effects ; Organic mental disorders. Neuropsychology ; Parkinson Disease - diagnosis ; Parkinson Disease - epidemiology ; Parkinson Disease - etiology ; Parkinson's disease ; Pesticides ; Pesticides - adverse effects ; Pesticides, fertilizers and other agrochemicals toxicology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Toxicology</subject><ispartof>Environmental research, 2013, Vol.120, p.96-101</ispartof><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-f348699e6b28acd0c66a04be24dd91d136822a1bb71910bd28abe3691fa54bb93</citedby><cites>FETCH-LOGICAL-c491t-f348699e6b28acd0c66a04be24dd91d136822a1bb71910bd28abe3691fa54bb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27062288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23092715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steenland, K.</creatorcontrib><creatorcontrib>Wesseling, C.</creatorcontrib><creatorcontrib>Román, N.</creatorcontrib><creatorcontrib>Quirós, I.</creatorcontrib><creatorcontrib>Juncos, J.L.</creatorcontrib><title>Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Pesticides have been associated with Parkinson's disease (PD) in many studies, and with Alzheimer's disease (AD) in a few.
We conducted screening tests for neurologic disease and occupational pesticide use in a population-based sample of 400 elderly subjects at two government-run clinics in Costa Rica; 361 subjects who failed the initial screen were given both the Mini-mental States Exam (MMSE) and a modified version of a 10-item United Parkinson's Disease Rating Motor Subscale (UPDRS). Among subjects who failed either test, 144 were then examined by a neurologist.
Past occupational pesticide exposure was reported by 18% of subjects. Exposed subjects performed worse on the MMSE than the non-exposed (mean 24.5 versus 25.9, p=0.01, adjusted for age, sex, and education). The exposed had significantly elevated risks of abnormal scores on two UPDRS items, tremor-at-rest (OR 2.58, 1.28–5.23), and finger-tapping (OR=2.94, 95% CI 1.03–8.41). Thirty-three (23%) of those examined by the neurologist were diagnosed with possible/probable PD, 3–4 times the expected based on international data; 85% of these cases had not been previously diagnosed. Among subjects who took the UPDRS, the exposed had an increased risk of PD (OR=2.57, 95% CI 0.91–7.26). No excess risk was found for a diagnosis of AD or mild cognitive impairment.
Elderly subjects with past occupational pesticide exposure performed significantly worse on screening tests for dementia and PD, and had an increased risk of an eventual PD diagnosis. Screening may be particularly appropriate among elderly subjects with past pesticide exposure.
► We screened 400 elderly subjects for neurologic disease and pesticide exposure in Costa Rica in 2 government clinics. ► Those with self-reported past occupational pesticide exposure performed significantly worse on cognitive and motor tests. ► Those reporting past occupational pesticide exposure had an odds ratio of 2.57 (0.91–7.26) for Parkinson's disease. ► Prevalence of Parkinson's disease was 3–4 times the expected in this population. ► Screening for neurologic disease may be particularly appropriate for those with past pesticide exposure.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Costa Rica - epidemiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia - diagnosis</subject><subject>Dementia - epidemiology</subject><subject>Dementia - etiology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Mild cognitive impairment</subject><subject>Neurology</subject><subject>Occupation</subject><subject>Occupational Exposure - adverse effects</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson's disease</subject><subject>Pesticides</subject><subject>Pesticides - adverse effects</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Toxicology</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9rHCEYBnApDc027TcoxUuhl5n46owzXgpl6T8IBEJ6FkffCS6zOtWZJaFfvia7bW-lJxF-j6_6EPIGWA0M5OWuxnBImGvOgNesrxk0z8gGmJIVU614TjaMgaiUaOGcvMx5V7bQCvaCnHPBFO-g3ZCf19aus1l8DGaiM-bFW--Q4v0c85qQmuBotgkx-HBHlwIyHWOiAdcUHd5hwFTiB6TOZzS5JPaxSBMoTg7T9EDnOK_T0wjqA93GvBh64615Rc5GM2V8fVovyPfPn263X6ur6y_fth-vKtsoWKpRNL1UCuXAe2Mds1Ia1gzIG-cUOBCy59zAMHSggA2uqAGFVDCathkGJS7I--O5c4o_1vICvffZ4jSZgHHNGngngANA8x9U9rKFDlihzZHaFHNOOOo5-b1JDxqYfmxI7_SxIf3YkGa9Zk8T3p4mrMMe3Z_Q70oKeHcCJlszjckE6_Nf1zHJed8X9-HosHzdwWPS2XoMFp1PaBftov_3TX4BYiyyzA</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Steenland, K.</creator><creator>Wesseling, C.</creator><creator>Román, N.</creator><creator>Quirós, I.</creator><creator>Juncos, J.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T2</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica</title><author>Steenland, K. ; Wesseling, C. ; Román, N. ; Quirós, I. ; Juncos, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-f348699e6b28acd0c66a04be24dd91d136822a1bb71910bd28abe3691fa54bb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Costa Rica - epidemiology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia - diagnosis</topic><topic>Dementia - epidemiology</topic><topic>Dementia - etiology</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Mild cognitive impairment</topic><topic>Neurology</topic><topic>Occupation</topic><topic>Occupational Exposure - adverse effects</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson Disease - etiology</topic><topic>Parkinson's disease</topic><topic>Pesticides</topic><topic>Pesticides - adverse effects</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steenland, K.</creatorcontrib><creatorcontrib>Wesseling, C.</creatorcontrib><creatorcontrib>Román, N.</creatorcontrib><creatorcontrib>Quirós, I.</creatorcontrib><creatorcontrib>Juncos, J.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steenland, K.</au><au>Wesseling, C.</au><au>Román, N.</au><au>Quirós, I.</au><au>Juncos, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2013</date><risdate>2013</risdate><volume>120</volume><spage>96</spage><epage>101</epage><pages>96-101</pages><issn>0013-9351</issn><eissn>1096-0953</eissn><coden>ENVRAL</coden><abstract>Pesticides have been associated with Parkinson's disease (PD) in many studies, and with Alzheimer's disease (AD) in a few.
We conducted screening tests for neurologic disease and occupational pesticide use in a population-based sample of 400 elderly subjects at two government-run clinics in Costa Rica; 361 subjects who failed the initial screen were given both the Mini-mental States Exam (MMSE) and a modified version of a 10-item United Parkinson's Disease Rating Motor Subscale (UPDRS). Among subjects who failed either test, 144 were then examined by a neurologist.
Past occupational pesticide exposure was reported by 18% of subjects. Exposed subjects performed worse on the MMSE than the non-exposed (mean 24.5 versus 25.9, p=0.01, adjusted for age, sex, and education). The exposed had significantly elevated risks of abnormal scores on two UPDRS items, tremor-at-rest (OR 2.58, 1.28–5.23), and finger-tapping (OR=2.94, 95% CI 1.03–8.41). Thirty-three (23%) of those examined by the neurologist were diagnosed with possible/probable PD, 3–4 times the expected based on international data; 85% of these cases had not been previously diagnosed. Among subjects who took the UPDRS, the exposed had an increased risk of PD (OR=2.57, 95% CI 0.91–7.26). No excess risk was found for a diagnosis of AD or mild cognitive impairment.
Elderly subjects with past occupational pesticide exposure performed significantly worse on screening tests for dementia and PD, and had an increased risk of an eventual PD diagnosis. Screening may be particularly appropriate among elderly subjects with past pesticide exposure.
► We screened 400 elderly subjects for neurologic disease and pesticide exposure in Costa Rica in 2 government clinics. ► Those with self-reported past occupational pesticide exposure performed significantly worse on cognitive and motor tests. ► Those reporting past occupational pesticide exposure had an odds ratio of 2.57 (0.91–7.26) for Parkinson's disease. ► Prevalence of Parkinson's disease was 3–4 times the expected in this population. ► Screening for neurologic disease may be particularly appropriate for those with past pesticide exposure.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23092715</pmid><doi>10.1016/j.envres.2012.08.014</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer's disease Biological and medical sciences Costa Rica - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - diagnosis Dementia - epidemiology Dementia - etiology Female Geriatrics Humans Logistic Models Male Mass Screening Medical sciences Mild cognitive impairment Neurology Occupation Occupational Exposure - adverse effects Organic mental disorders. Neuropsychology Parkinson Disease - diagnosis Parkinson Disease - epidemiology Parkinson Disease - etiology Parkinson's disease Pesticides Pesticides - adverse effects Pesticides, fertilizers and other agrochemicals toxicology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Toxicology |
| title | Occupational pesticide exposure and screening tests for neurodegenerative disease among an elderly population in Costa Rica |
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