Trefoil factor-2 reverses airway remodeling changes in allergic airways disease

Trefoil factor 2 (TFF2) is a small peptide with an important role in mucosal repair. TFF2 is up-regulated in asthma, suggesting a role in asthma pathogenesis. Given its known biological role in promoting epithelial repair, TFF2 might be expected to exert a protective function in limiting the progres...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2013-01, Vol.48 (1), p.135-144
Hauptverfasser:	Royce, Simon G, Lim, Clarice, Muljadi, Ruth C, Samuel, Chrishan S, Ververis, Katherine, Karagiannis, Tom C, Giraud, Andrew S, Tang, Mimi L K
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Airway Resistance - drug effects Animals Annexin A5 - metabolism Asthma - drug therapy Asthma - pathology Asthma - physiopathology Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - physiopathology Disease Models, Animal Female Immunohistochemistry Lung - drug effects Lung - pathology Lung - physiopathology Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred BALB C Mucins - pharmacology Mucins - physiology Muscle Proteins - pharmacology Muscle Proteins - physiology Ovalbumin - immunology Peptides - pharmacology Peptides - physiology Receptor, Epidermal Growth Factor - metabolism Recombinant Proteins - pharmacology Respiratory Mucosa - drug effects Respiratory Mucosa - pathology Transforming Growth Factor beta1 - metabolism Trefoil Factor-2
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