PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation

Advanced glycation end products (AGEs) formed at an accelerated rate under diabetes, elicit oxidative and pro-apoptotic reactions in various types of cells, including podocytes, thus being involved in the development and progression of diabetic nephropathy. Recently, we, along with others, have foun...

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Veröffentlicht in:	Microvascular research 2013-01, Vol.85, p.54-58
Hauptverfasser:	Ishibashi, Yuji, Matsui, Takanori, Ohta, Keisuke, Tanoue, Ryuichiro, Takeuchi, Masayoshi, Asanuma, Katsuhiko, Fukami, Kei, Okuda, Seiya, Nakamura, Kei-ichiro, Yamagishi, Sho-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Animals Apoptosis Cattle Cell Differentiation Ethidium - analogs & derivatives Ethidium - pharmacology Eye Proteins - metabolism Gene Expression Regulation Glycation End Products, Advanced - metabolism Glycoproteins - metabolism Mice Nerve Growth Factors - metabolism Neurons - metabolism Podocytes - cytology PPAR gamma - metabolism RNA, Messenger - metabolism Serpins - metabolism Serum Albumin, Bovine - metabolism Transcription, Genetic Up-Regulation
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