Triple-Stranded DNA Containing 8‑Oxo-7,8-dihydro-2′-deoxyguanosine: Implication in the Design of Selective Aptamer Sensors for 8‑Oxo-7,8-dihydroguanine

8-Oxo-7,8-dihydroguanine (8-oxoG, or OG) as a free base has been widely considered as a biomarker for DNA oxidative damage. Currently no fluorescence sensor has been developed to directly detect 8-oxoG less than 100 nM. In this study, two triple-stranded DNAs were selected as the scaffolds to ration...

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Veröffentlicht in:	Analytical chemistry (Washington) 2013-01, Vol.85 (1), p.201-207
Hauptverfasser:	Zhang, Qian, Wang, Yiqi, Meng, Xianyang, Dhar, Rik, Huang, Haidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Aptamers, Nucleotide - chemistry Biomarkers Biosensing Techniques Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Deoxyribonucleic acid DNA DNA - chemistry Fluorescence Fluorescent Dyes - chemistry Sensors Spectrometry, Fluorescence Transition Temperature Ultraviolet Rays
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