Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre
In order to assess the efficacy of modern antiepileptic drug (AED) therapy, we collected data from 517 consecutive adult outpatients referred to our centre between March and August 2011. In total, 211 patients (40.8%) were treated with monotherapy, 208 patients (40.2%) with a combination of two AEDs...
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| Veröffentlicht in: | Epileptic disorders 2012-12, Vol.14 (4), p.379-387 |
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| creator | Steinhoff, Bernhard J. Staack, Anke Maren Wisniewski, Ilona |
| description | In order to assess the efficacy of modern antiepileptic drug (AED) therapy, we collected data from 517 consecutive adult outpatients referred to our centre between March and August 2011. In total, 211 patients (40.8%) were treated with monotherapy, 208 patients (40.2%) with a combination of two AEDs, and for the remaining patients (
n
=98; 19%) more than two AEDs were combined. The most common AEDs were valproate, lamotrigine, carbamazepine, and levetiracetam. Of the recent AEDs, levetiracetamwas the leading drug with regards to drug combinations. Freedom of seizures for more than one year was achieved in 291 patients (56.3%). Under monotherapy, 168 patients (32.5% of all patients; 79.6% of patients with monotherapy) became seizure-free. Seizure-freedom with two AEDs was achieved in 103 patients (19.9% of all patients; 49.5% of patients with two AEDs) and in 20 patients with three AEDs (3.9% of all patients; 25.3% of patients with three AEDs). We conclude from this cross-sectional survey in a large patient group that combinations may still lead to treatment success in a considerable proportion of patients. |
| doi_str_mv | 10.1684/epd.2012.0544 |
| format | Article |
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n
=98; 19%) more than two AEDs were combined. The most common AEDs were valproate, lamotrigine, carbamazepine, and levetiracetam. Of the recent AEDs, levetiracetamwas the leading drug with regards to drug combinations. Freedom of seizures for more than one year was achieved in 291 patients (56.3%). Under monotherapy, 168 patients (32.5% of all patients; 79.6% of patients with monotherapy) became seizure-free. Seizure-freedom with two AEDs was achieved in 103 patients (19.9% of all patients; 49.5% of patients with two AEDs) and in 20 patients with three AEDs (3.9% of all patients; 25.3% of patients with three AEDs). We conclude from this cross-sectional survey in a large patient group that combinations may still lead to treatment success in a considerable proportion of patients.</description><identifier>ISSN: 1950-6945</identifier><identifier>ISSN: 1294-9361</identifier><identifier>EISSN: 1950-6945</identifier><identifier>DOI: 10.1684/epd.2012.0544</identifier><identifier>PMID: 23274162</identifier><language>eng</language><publisher>Paris: John Libbey Eurotext</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ambulatory Care ; Anticonvulsants - therapeutic use ; Antiepileptic agents ; Carbamazepine ; Carbamazepine - therapeutic use ; Convulsions & seizures ; Cross-Sectional Studies ; Drug therapy ; Drug Therapy, Combination - methods ; Epilepsy ; Epilepsy - drug therapy ; Etiracetam ; Female ; Humans ; Lamotrigine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurobiology ; Neurology ; Neuropsychology ; Neuroradiology ; Original Article ; Piracetam - analogs & derivatives ; Piracetam - therapeutic use ; Seizures ; Treatment Outcome ; Triazines - therapeutic use ; Valproic acid ; Valproic Acid - therapeutic use ; Young Adult</subject><ispartof>Epileptic disorders, 2012-12, Vol.14 (4), p.379-387</ispartof><rights>John Libbey Eurotext and Springer-Verlag France 2012</rights><rights>International League Against Epilepsy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-7c4e44ffe23c3d22e7cf245bd22ca1f9a3ea5e049f71ec2d8959207d7cde51fb3</citedby><cites>FETCH-LOGICAL-c360t-7c4e44ffe23c3d22e7cf245bd22ca1f9a3ea5e049f71ec2d8959207d7cde51fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23274162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinhoff, Bernhard J.</creatorcontrib><creatorcontrib>Staack, Anke Maren</creatorcontrib><creatorcontrib>Wisniewski, Ilona</creatorcontrib><title>Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre</title><title>Epileptic disorders</title><addtitle>Epileptic Disord</addtitle><addtitle>Epileptic Disord</addtitle><description>In order to assess the efficacy of modern antiepileptic drug (AED) therapy, we collected data from 517 consecutive adult outpatients referred to our centre between March and August 2011. In total, 211 patients (40.8%) were treated with monotherapy, 208 patients (40.2%) with a combination of two AEDs, and for the remaining patients (
n
=98; 19%) more than two AEDs were combined. The most common AEDs were valproate, lamotrigine, carbamazepine, and levetiracetam. Of the recent AEDs, levetiracetamwas the leading drug with regards to drug combinations. Freedom of seizures for more than one year was achieved in 291 patients (56.3%). Under monotherapy, 168 patients (32.5% of all patients; 79.6% of patients with monotherapy) became seizure-free. Seizure-freedom with two AEDs was achieved in 103 patients (19.9% of all patients; 49.5% of patients with two AEDs) and in 20 patients with three AEDs (3.9% of all patients; 25.3% of patients with three AEDs). We conclude from this cross-sectional survey in a large patient group that combinations may still lead to treatment success in a considerable proportion of patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ambulatory Care</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antiepileptic agents</subject><subject>Carbamazepine</subject><subject>Carbamazepine - therapeutic use</subject><subject>Convulsions & seizures</subject><subject>Cross-Sectional Studies</subject><subject>Drug therapy</subject><subject>Drug Therapy, Combination - methods</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Etiracetam</subject><subject>Female</subject><subject>Humans</subject><subject>Lamotrigine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Original Article</subject><subject>Piracetam - analogs & derivatives</subject><subject>Piracetam - therapeutic use</subject><subject>Seizures</subject><subject>Treatment Outcome</subject><subject>Triazines - therapeutic use</subject><subject>Valproic acid</subject><subject>Valproic Acid - therapeutic use</subject><subject>Young Adult</subject><issn>1950-6945</issn><issn>1294-9361</issn><issn>1950-6945</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0TlPwzAUB3ALgWg5RlZkiYUlxXacuhlRVQ5RiQGYLdd5aV3SJPgAlU-PQ8shxOQnv5__tvwQOqFkQIcjfgFtMWCEsgHJON9BfZpnJBnmPNv9VffQgXNLQljcoPuox1ImOB2yPmofwLwHC1g3tbdNhd-MX2BVewOtqaD1RuPChjn2C7CqXWNT44yKjjvQwZtXwKoIlcdN8K2Kx2rvsPKdx3eNfcaTzxy3xuPYsnCE9kpVOTjerofo6WryOL5JpvfXt-PLaaLTIfGJ0Bw4L0tgqU4LxkDokvFsFkutaJmrFFQGhOeloKBZMcqznBFRCF1ARstZeojON7mtbV4COC9XxmmoKlVDE5ykTKSUshEhkZ79ocsm2Dq-TrKRSImIrlPJRmnbOGehlK01K2XXkhLZjULGUchuFLIbRfSn29QwW0Hxrb_-PoLBBrjYqudgf679P_ED0OaU2A</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Steinhoff, Bernhard J.</creator><creator>Staack, Anke Maren</creator><creator>Wisniewski, Ilona</creator><general>John Libbey Eurotext</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre</title><author>Steinhoff, Bernhard J. ; Staack, Anke Maren ; Wisniewski, Ilona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-7c4e44ffe23c3d22e7cf245bd22ca1f9a3ea5e049f71ec2d8959207d7cde51fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ambulatory Care</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Antiepileptic agents</topic><topic>Carbamazepine</topic><topic>Carbamazepine - therapeutic use</topic><topic>Convulsions & seizures</topic><topic>Cross-Sectional Studies</topic><topic>Drug therapy</topic><topic>Drug Therapy, Combination - methods</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Etiracetam</topic><topic>Female</topic><topic>Humans</topic><topic>Lamotrigine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Original Article</topic><topic>Piracetam - analogs & derivatives</topic><topic>Piracetam - therapeutic use</topic><topic>Seizures</topic><topic>Treatment Outcome</topic><topic>Triazines - therapeutic use</topic><topic>Valproic acid</topic><topic>Valproic Acid - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinhoff, Bernhard J.</creatorcontrib><creatorcontrib>Staack, Anke Maren</creatorcontrib><creatorcontrib>Wisniewski, Ilona</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Epileptic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinhoff, Bernhard J.</au><au>Staack, Anke Maren</au><au>Wisniewski, Ilona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre</atitle><jtitle>Epileptic disorders</jtitle><stitle>Epileptic Disord</stitle><addtitle>Epileptic Disord</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>14</volume><issue>4</issue><spage>379</spage><epage>387</epage><pages>379-387</pages><issn>1950-6945</issn><issn>1294-9361</issn><eissn>1950-6945</eissn><abstract>In order to assess the efficacy of modern antiepileptic drug (AED) therapy, we collected data from 517 consecutive adult outpatients referred to our centre between March and August 2011. In total, 211 patients (40.8%) were treated with monotherapy, 208 patients (40.2%) with a combination of two AEDs, and for the remaining patients (
n
=98; 19%) more than two AEDs were combined. The most common AEDs were valproate, lamotrigine, carbamazepine, and levetiracetam. Of the recent AEDs, levetiracetamwas the leading drug with regards to drug combinations. Freedom of seizures for more than one year was achieved in 291 patients (56.3%). Under monotherapy, 168 patients (32.5% of all patients; 79.6% of patients with monotherapy) became seizure-free. Seizure-freedom with two AEDs was achieved in 103 patients (19.9% of all patients; 49.5% of patients with two AEDs) and in 20 patients with three AEDs (3.9% of all patients; 25.3% of patients with three AEDs). We conclude from this cross-sectional survey in a large patient group that combinations may still lead to treatment success in a considerable proportion of patients.</abstract><cop>Paris</cop><pub>John Libbey Eurotext</pub><pmid>23274162</pmid><doi>10.1684/epd.2012.0544</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Ambulatory Care Anticonvulsants - therapeutic use Antiepileptic agents Carbamazepine Carbamazepine - therapeutic use Convulsions & seizures Cross-Sectional Studies Drug therapy Drug Therapy, Combination - methods Epilepsy Epilepsy - drug therapy Etiracetam Female Humans Lamotrigine Male Medicine Medicine & Public Health Middle Aged Neurobiology Neurology Neuropsychology Neuroradiology Original Article Piracetam - analogs & derivatives Piracetam - therapeutic use Seizures Treatment Outcome Triazines - therapeutic use Valproic acid Valproic Acid - therapeutic use Young Adult |
| title | Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre |
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