Gene transcription and biomarker responses in the clam Ruditapes philippinarum after exposure to ibuprofen

► Clams were exposed for 1, 3, 5 and 7 days to differing concentrations of ibuprofen. ► The effects on biomarker responses and digestive gland transcriptome were evaluated. ► IBU affected significantly biomarker responses. ► IBU can interfere with various signalling pathways in clams. ► The integrat...

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Veröffentlicht in:	Aquatic toxicology 2013-01, Vol.126 (15), p.17-29
Hauptverfasser:	Milan, Massimo, Pauletto, Marianna, Patarnello, Tomaso, Bargelloni, Luca, Marin, Maria Gabriella, Matozzo, Valerio
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Analysis of Variance Animal, plant and microbial ecology Animals apoptosis Applied ecology aquatic environment Aquatic toxicology arachidonic acid Biological and medical sciences Biomarker biomarkers Biomarkers - analysis Bivalvia - drug effects Clam clams cytochrome P-450 Ecotoxicology, biological effects of pollution enzyme activity exposure duration Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene transcription General aspects genes Gills - drug effects glutathione transferase Ibuprofen Ibuprofen - toxicity lysozyme mechanism of action metabolism microarray technology nontarget organisms Pharmaceutical pollution receptors Ruditapes philippinarum superoxide dismutase Techniques transcription (genetics) Transcriptome Water Pollutants, Chemical - toxicity
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