cGMP–PDE3–cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat

In the present study, we investigated the mechanism of C-type natriuretic peptide (CNP)-induced inhibitory effect on spontaneous contraction of gastric antral smooth muscle to clarify CNP-NPR-B/pGC-cGMP downstream signal transduction pathway using organ bath and ELISA methods in rat. CNP significant...

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Veröffentlicht in:	Regulatory peptides 2013-01, Vol.180, p.43-49
Hauptverfasser:	Cai, Ying-Lan, Sun, Qian, Huang, Xu, Jiang, Jing-Zhi, Zhang, Mo-Han, Piao, Li-Hua, Jin, Zheng, Xu, Wen-Xie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cGMP–PDE3–cAMP CNP Cyclic AMP - metabolism Cyclic GMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 - metabolism Female Gastric smooth muscle Gastrointestinal Motility - physiology Male Natriuretic Peptide, C-Type - physiology PDE2 PDE3 Rats Signal Transduction
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