Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)
In six normal‐weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution....
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2012-12, Vol.96 (6), p.1054-1064 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Verbrugghe, A Hesta, M Daminet, S Polis, I Holst, J. J Buyse, J Wuyts, B Janssens, G. P. J |
| description | In six normal‐weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution. Normal saline was given as control solution. Solutions were infused into the hindgut over 30 min. Blood samples were obtained prior to and at various time points after starting the infusion. As body condition did not affect evaluated parameters, all data were pooled. Plasma glucose concentrations showed differences neither over time nor during or after infusion with propionate or control. Plasma amino acid concentrations rose over time (p |
| doi_str_mv | 10.1111/j.1439-0396.2011.01220.x |
| format | Article |
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J ; Buyse, J ; Wuyts, B ; Janssens, G. P. J</creator><creatorcontrib>Verbrugghe, A ; Hesta, M ; Daminet, S ; Polis, I ; Holst, J. J ; Buyse, J ; Wuyts, B ; Janssens, G. P. J</creatorcontrib><description>In six normal‐weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution. Normal saline was given as control solution. Solutions were infused into the hindgut over 30 min. Blood samples were obtained prior to and at various time points after starting the infusion. As body condition did not affect evaluated parameters, all data were pooled. Plasma glucose concentrations showed differences neither over time nor during or after infusion with propionate or control. Plasma amino acid concentrations rose over time (p < 0.001), but were similar for both infusions. Plasma propionylcarnitine rose markedly towards the end of the propionate infusion and decreased afterwards (p < 0.001), whereas 3‐hydroxy‐3‐methylglutarylcarnitine was lower 30 (p = 0.005) and 60 min (p = 0.032) after ending propionate infusions and acetylcarnitine tended to fall at the same time points (p = 0.079; p = 0.080), suggesting inhibition of gluconeogenesis from pyruvate and amino acids, but initiation of propionate‐induced gluconeogenesis. In conclusion, propionate absorbed from the colon is hypothesized to act as gluconeogenic substrate, regardless of the cat’s body condition.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/j.1439-0396.2011.01220.x</identifier><identifier>PMID: 21895780</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Absorption ; acylcarnitine profile ; amino acid composition ; amino acid metabolism ; amino acids ; Animal Feed - analysis ; Animal Nutritional Physiological Phenomena ; Animals ; blood ; blood glucose ; body condition ; cat ; cats ; Cats - metabolism ; Cattle ; Colon ; Colon - metabolism ; Cross-Over Studies ; Diet - veterinary ; Female ; gluconeogenesis ; Gluconeogenesis - physiology ; glucose metabolism ; hindgut ; Hyperglycemia ; ideal body weight ; Male ; Obesity ; propionate ; Propionates - metabolism ; Propionates - pharmacokinetics ; sodium chloride ; sodium propionate</subject><ispartof>Journal of animal physiology and animal nutrition, 2012-12, Vol.96 (6), p.1054-1064</ispartof><rights>2011 Blackwell Verlag GmbH</rights><rights>2011 Blackwell Verlag GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4920-21de8ca7d53cf4b249504d8cbbc310aa7764b77ed447aca4f7b8741bbd307c693</citedby><cites>FETCH-LOGICAL-c4920-21de8ca7d53cf4b249504d8cbbc310aa7764b77ed447aca4f7b8741bbd307c693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0396.2011.01220.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0396.2011.01220.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21895780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verbrugghe, A</creatorcontrib><creatorcontrib>Hesta, M</creatorcontrib><creatorcontrib>Daminet, S</creatorcontrib><creatorcontrib>Polis, I</creatorcontrib><creatorcontrib>Holst, J. J</creatorcontrib><creatorcontrib>Buyse, J</creatorcontrib><creatorcontrib>Wuyts, B</creatorcontrib><creatorcontrib>Janssens, G. P. J</creatorcontrib><title>Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>In six normal‐weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution. Normal saline was given as control solution. Solutions were infused into the hindgut over 30 min. Blood samples were obtained prior to and at various time points after starting the infusion. As body condition did not affect evaluated parameters, all data were pooled. Plasma glucose concentrations showed differences neither over time nor during or after infusion with propionate or control. Plasma amino acid concentrations rose over time (p < 0.001), but were similar for both infusions. Plasma propionylcarnitine rose markedly towards the end of the propionate infusion and decreased afterwards (p < 0.001), whereas 3‐hydroxy‐3‐methylglutarylcarnitine was lower 30 (p = 0.005) and 60 min (p = 0.032) after ending propionate infusions and acetylcarnitine tended to fall at the same time points (p = 0.079; p = 0.080), suggesting inhibition of gluconeogenesis from pyruvate and amino acids, but initiation of propionate‐induced gluconeogenesis. In conclusion, propionate absorbed from the colon is hypothesized to act as gluconeogenic substrate, regardless of the cat’s body condition.</description><subject>Absorption</subject><subject>acylcarnitine profile</subject><subject>amino acid composition</subject><subject>amino acid metabolism</subject><subject>amino acids</subject><subject>Animal Feed - analysis</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>blood</subject><subject>blood glucose</subject><subject>body condition</subject><subject>cat</subject><subject>cats</subject><subject>Cats - metabolism</subject><subject>Cattle</subject><subject>Colon</subject><subject>Colon - metabolism</subject><subject>Cross-Over Studies</subject><subject>Diet - veterinary</subject><subject>Female</subject><subject>gluconeogenesis</subject><subject>Gluconeogenesis - physiology</subject><subject>glucose metabolism</subject><subject>hindgut</subject><subject>Hyperglycemia</subject><subject>ideal body weight</subject><subject>Male</subject><subject>Obesity</subject><subject>propionate</subject><subject>Propionates - metabolism</subject><subject>Propionates - pharmacokinetics</subject><subject>sodium chloride</subject><subject>sodium propionate</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS0EokPhFcASmyI1wX-J40UXqNApVTVU0IqlZTvO4CGJBzuB6dvXadpZdMXd-Mr-zvG1DwAQoxyn-rjJMaMiQ1SUOUEY5wgTgvLdM7DYHzwHCyQozkjaOACvYtwghHmBypfggOBKFLxCC7C7Cn7rfK8GC5WOPmhbwyb4Dg6_LDS-9T1UZohQRbhuR-N769e2dwbGUcchTDqXEJh6ZwZoVOjdXx_s8b1B7Tsbh0QbNcCjM9u6OLVj_PAavGhUG-2bh_UQ3Jx9uT49zy6_Lb-efrrMDBMEZQTXtjKK1wU1DdOEiQKxujJaG4qRUpyXTHNua8a4Moo1XFecYa1rirgpBT0ER7PvNvg_YxpGdi4a27YqvWSMEhOejEqKSELfP0E3fgx9mk7i9K2lEJQUiapmygQfY7CN3AbXqXArMZJTOnIjpxDkFIKc0pH36chdkr59uGDUna33wsc4EnAyA_9ca2__21heXK2mLumzWe_iYHd7vQq_ZckpL-TP1VKultXFZ3F-Lb8n_t3MN8pLtQ4uypsfyZmhVILxgt4BFXG2VQ</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Verbrugghe, A</creator><creator>Hesta, M</creator><creator>Daminet, S</creator><creator>Polis, I</creator><creator>Holst, J. J</creator><creator>Buyse, J</creator><creator>Wuyts, B</creator><creator>Janssens, G. P. J</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)</title><author>Verbrugghe, A ; Hesta, M ; Daminet, S ; Polis, I ; Holst, J. J ; Buyse, J ; Wuyts, B ; Janssens, G. P. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4920-21de8ca7d53cf4b249504d8cbbc310aa7764b77ed447aca4f7b8741bbd307c693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorption</topic><topic>acylcarnitine profile</topic><topic>amino acid composition</topic><topic>amino acid metabolism</topic><topic>amino acids</topic><topic>Animal Feed - analysis</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>blood</topic><topic>blood glucose</topic><topic>body condition</topic><topic>cat</topic><topic>cats</topic><topic>Cats - metabolism</topic><topic>Cattle</topic><topic>Colon</topic><topic>Colon - metabolism</topic><topic>Cross-Over Studies</topic><topic>Diet - veterinary</topic><topic>Female</topic><topic>gluconeogenesis</topic><topic>Gluconeogenesis - physiology</topic><topic>glucose metabolism</topic><topic>hindgut</topic><topic>Hyperglycemia</topic><topic>ideal body weight</topic><topic>Male</topic><topic>Obesity</topic><topic>propionate</topic><topic>Propionates - metabolism</topic><topic>Propionates - pharmacokinetics</topic><topic>sodium chloride</topic><topic>sodium propionate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verbrugghe, A</creatorcontrib><creatorcontrib>Hesta, M</creatorcontrib><creatorcontrib>Daminet, S</creatorcontrib><creatorcontrib>Polis, I</creatorcontrib><creatorcontrib>Holst, J. 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J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verbrugghe, A</au><au>Hesta, M</au><au>Daminet, S</au><au>Polis, I</au><au>Holst, J. J</au><au>Buyse, J</au><au>Wuyts, B</au><au>Janssens, G. P. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus)</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2012-12</date><risdate>2012</risdate><volume>96</volume><issue>6</issue><spage>1054</spage><epage>1064</epage><pages>1054-1064</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>In six normal‐weight and six obese cats, the metabolic effect of propionate absorbed from the colon was assessed. Two colonic infusions were tested in a crossover design with intervals of 4 weeks. The test solution contained 4 mmol sodium propionate per kg ideal body weight in a 0.2% NaCl solution. Normal saline was given as control solution. Solutions were infused into the hindgut over 30 min. Blood samples were obtained prior to and at various time points after starting the infusion. As body condition did not affect evaluated parameters, all data were pooled. Plasma glucose concentrations showed differences neither over time nor during or after infusion with propionate or control. Plasma amino acid concentrations rose over time (p < 0.001), but were similar for both infusions. Plasma propionylcarnitine rose markedly towards the end of the propionate infusion and decreased afterwards (p < 0.001), whereas 3‐hydroxy‐3‐methylglutarylcarnitine was lower 30 (p = 0.005) and 60 min (p = 0.032) after ending propionate infusions and acetylcarnitine tended to fall at the same time points (p = 0.079; p = 0.080), suggesting inhibition of gluconeogenesis from pyruvate and amino acids, but initiation of propionate‐induced gluconeogenesis. In conclusion, propionate absorbed from the colon is hypothesized to act as gluconeogenic substrate, regardless of the cat’s body condition.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21895780</pmid><doi>10.1111/j.1439-0396.2011.01220.x</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of animal physiology and animal nutrition, 2012-12, Vol.96 (6), p.1054-1064 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Absorption acylcarnitine profile amino acid composition amino acid metabolism amino acids Animal Feed - analysis Animal Nutritional Physiological Phenomena Animals blood blood glucose body condition cat cats Cats - metabolism Cattle Colon Colon - metabolism Cross-Over Studies Diet - veterinary Female gluconeogenesis Gluconeogenesis - physiology glucose metabolism hindgut Hyperglycemia ideal body weight Male Obesity propionate Propionates - metabolism Propionates - pharmacokinetics sodium chloride sodium propionate |
| title | Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus) |
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