Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge

Purpose This proteomics study was designed to determine the utility of iTRAQ MALDI‐TOF/TOF technology to compare plasma samples from carefully phenotyped mild, atopic asthma subjects undergoing allergen inhalation challenge. Experimental design Eight adult subjects with mild, allergic asthma (four e...

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Veröffentlicht in:	Proteomics. Clinical applications 2012-10, Vol.6 (9-10), p.476-485
Hauptverfasser:	Singh, Amrit, Cohen Freue, Gabriela V., Oosthuizen, Jean L., Kam, Sarah H. Y., Ruan, Jian, Takhar, Mandeep K., Gauvreau, Gail M., O'Byrne, Paul M., FitzGerald, J. Mark, Boulet, Louis-Philippe, Borchers, Christoph H., Tebbutt, Scott J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Allergen inhalation challenge Allergens Allergens - immunology Asthma Asthma - blood Asthma - immunology Asthma - pathology Atopy Biological and medical sciences Chromatography, High Pressure Liquid Chronic obstructive pulmonary disease, asthma Discriminant Analysis Diverse techniques Early response Female Fibronectin Fibronectins - blood Fundamental and applied biological sciences. Psychology Humans Inhalation Late response Male Medical sciences Middle Aged Molecular and cellular biology Plasma Pneumology Proteome - analysis Proteomics Respiratory diseases Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Therapeutic applications Young Adult
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