Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats
Oxidative stress and apoptotic cell death in kidney have been suggested as contributing factors in the development and complication of diabetes especially in diabetic nephropathy (DN). This study investigated the effects of trigonelline (TG) on the renal functional, morphological changes and renal a...
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| Veröffentlicht in: | International immunopharmacology 2012-12, Vol.14 (4), p.740-748 |
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| description | Oxidative stress and apoptotic cell death in kidney have been suggested as contributing factors in the development and complication of diabetes especially in diabetic nephropathy (DN). This study investigated the effects of trigonelline (TG) on the renal functional, morphological changes and renal apoptosis in neonatal diabetic rats, a model of non-insulin-dependent diabetes mellitus. Diabetes mellitus was induced in one day old neonatal Wistar rat pups by an intraperitoneal (i.p.) injection of streptozotocin (STZ) (50mg/kg) and monitored for 16weeks thereafter. The diabetic rats were divided as follows: the nSTZ diabetic group, the TG (50mg/kg) treated diabetic group, and the TG (100mg/kg) treated diabetic group. The age matched nondiabetic group received an injection of citrate buffer (0.1M, pH4.5). At the end kidney samples were taken for light microscopic examinations. The levels of serum creatinine and BUN were significantly low in TG (100mg/kg) treated diabetic rats. Glomerular filtration rate was improved in TG treated rats. The activities of antioxidant enzyme and membrane bound enzyme were decreased and the levels of tumor necrotic factor (TNF-α) and hydroxyproline content were increased in renal tissues of the diabetic group. TG (100mg/kg/day) treatment for a period of 4weeks showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. The degenerative changes in kidney tissue and fibrosis were alleviated in the TG treated groups. These results suggested that TG might have a significant role in alleviating kidney damage in nSTZ-diabetic rats.
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► Trigonelline (TG) is a plant hormone which is claimed to have antidiabetic and hypoglycemic activities. ► Oxidative stress and apoptosis play a central role in diabetic nephropathy. ► TG treatment ameliorates oxidative stress in mononuclear cells. ► Decreased apoptosis in renal cells confirmed the antiapoptotic role of trigonelline. ► Renal histology showed decreased tubular damage and fibrosis after TG treatment. |
| doi_str_mv | 10.1016/j.intimp.2012.10.004 |
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[Display omitted]
► Trigonelline (TG) is a plant hormone which is claimed to have antidiabetic and hypoglycemic activities. ► Oxidative stress and apoptosis play a central role in diabetic nephropathy. ► TG treatment ameliorates oxidative stress in mononuclear cells. ► Decreased apoptosis in renal cells confirmed the antiapoptotic role of trigonelline. ► Renal histology showed decreased tubular damage and fibrosis after TG treatment.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2012.10.004</identifier><identifier>PMID: 23102665</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Alkaloids - pharmacology ; Animal models ; Animals ; Animals, Newborn ; Antioxidants ; Apoptosis ; Apoptosis - drug effects ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Glucose ; Cardiology. Vascular system ; Citric acid ; Creatinine ; Diabetes mellitus ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - prevention & control ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - drug therapy ; Diabetic nephropathy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fibrosis ; Fibrosis - drug therapy ; Glomerular filtration rate ; Hydroxyproline ; Hypoglycemic Agents - pharmacology ; Insulin - blood ; Kidney ; Kidney - cytology ; Kidney - drug effects ; Kidney - metabolism ; Medical sciences ; Mononuclear cells ; Neonates ; Nephropathy ; Oxidative stress ; Oxidative Stress - drug effects ; pH effects ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Reactive oxygen species ; Streptozocin ; Trigonelline ; Tumors</subject><ispartof>International immunopharmacology, 2012-12, Vol.14 (4), p.740-748</ispartof><rights>2012 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-ee940a45ab2a2cd7cb35e7b21a23d48be291a2d57c7d7e1cce89c15a02ab5ef83</citedby><cites>FETCH-LOGICAL-c425t-ee940a45ab2a2cd7cb35e7b21a23d48be291a2d57c7d7e1cce89c15a02ab5ef83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2012.10.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26748667$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23102665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghule, Arvindkumar E.</creatorcontrib><creatorcontrib>Jadhav, Suresh S.</creatorcontrib><creatorcontrib>Bodhankar, Subhash L.</creatorcontrib><title>Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Oxidative stress and apoptotic cell death in kidney have been suggested as contributing factors in the development and complication of diabetes especially in diabetic nephropathy (DN). This study investigated the effects of trigonelline (TG) on the renal functional, morphological changes and renal apoptosis in neonatal diabetic rats, a model of non-insulin-dependent diabetes mellitus. Diabetes mellitus was induced in one day old neonatal Wistar rat pups by an intraperitoneal (i.p.) injection of streptozotocin (STZ) (50mg/kg) and monitored for 16weeks thereafter. The diabetic rats were divided as follows: the nSTZ diabetic group, the TG (50mg/kg) treated diabetic group, and the TG (100mg/kg) treated diabetic group. The age matched nondiabetic group received an injection of citrate buffer (0.1M, pH4.5). At the end kidney samples were taken for light microscopic examinations. The levels of serum creatinine and BUN were significantly low in TG (100mg/kg) treated diabetic rats. Glomerular filtration rate was improved in TG treated rats. The activities of antioxidant enzyme and membrane bound enzyme were decreased and the levels of tumor necrotic factor (TNF-α) and hydroxyproline content were increased in renal tissues of the diabetic group. TG (100mg/kg/day) treatment for a period of 4weeks showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. The degenerative changes in kidney tissue and fibrosis were alleviated in the TG treated groups. These results suggested that TG might have a significant role in alleviating kidney damage in nSTZ-diabetic rats.
[Display omitted]
► Trigonelline (TG) is a plant hormone which is claimed to have antidiabetic and hypoglycemic activities. ► Oxidative stress and apoptosis play a central role in diabetic nephropathy. ► TG treatment ameliorates oxidative stress in mononuclear cells. ► Decreased apoptosis in renal cells confirmed the antiapoptotic role of trigonelline. ► Renal histology showed decreased tubular damage and fibrosis after TG treatment.</description><subject>Alkaloids - pharmacology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Glucose</subject><subject>Cardiology. Vascular system</subject><subject>Citric acid</subject><subject>Creatinine</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - drug therapy</subject><subject>Diabetic nephropathy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymes</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fibrosis</subject><subject>Fibrosis - drug therapy</subject><subject>Glomerular filtration rate</subject><subject>Hydroxyproline</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - blood</subject><subject>Kidney</subject><subject>Kidney - cytology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Medical sciences</subject><subject>Mononuclear cells</subject><subject>Neonates</subject><subject>Nephropathy</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>pH effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive oxygen species</subject><subject>Streptozocin</subject><subject>Trigonelline</subject><subject>Tumors</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxiMEoqXwBgj5glQOu9hOHGcvSKjin1SJA8uFS-TYE3aWxA62tyI8Jk_EpLuUG-Jk-_Nvxp_nK4qngq8FF_XL_Rp9xnFaSy4kSWvOq3vFuWh0sxKaq_u0V7VeKV1vzopHKe05J70SD4szWQou61qdF7-2Eb8GD8OAHpgZYcAQTYbEHJoOMlq2myeIGXzCG2Aepl0Mk8m7mXUzS4dpipASBs9Cz8IPdCYvXMqLzNCzb-g8zMx4xyK4g80LS3oEbwZm6WVmpjDlkDDdUj128fZA0NKGrn6GHCwuZdQAHLkI3mQqvzN56T9tv7xgZD09Lh70Zkjw5LReFJ_fvtlevV9df3z34er19cpWUuUVwKbiplKmk0Zap21XKtCdFEaWrmo6kBvaOqWtdhqEtdBsrFCGS9Mp6Jvyorg89p1i-H6AlNsR0_IfQ_YOqRVSS12qSov_QKVoKCiuCK2OqKUhpAh9O0UcTZxbwdsl-HbfHoNvl-AXlYKnsmenFw7dCO6u6E_SBDw_ASZZM_TReIvpL1frqqlrTdyrIwc0uhuE2CaL4GnqGMHm1gX8t5PfQSrVMQ</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Ghule, Arvindkumar E.</creator><creator>Jadhav, Suresh S.</creator><creator>Bodhankar, Subhash L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20121201</creationdate><title>Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats</title><author>Ghule, Arvindkumar E. ; Jadhav, Suresh S. ; Bodhankar, Subhash L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-ee940a45ab2a2cd7cb35e7b21a23d48be291a2d57c7d7e1cce89c15a02ab5ef83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alkaloids - pharmacology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Glucose</topic><topic>Cardiology. Vascular system</topic><topic>Citric acid</topic><topic>Creatinine</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - drug therapy</topic><topic>Diabetic nephropathy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymes</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fibrosis</topic><topic>Fibrosis - drug therapy</topic><topic>Glomerular filtration rate</topic><topic>Hydroxyproline</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - blood</topic><topic>Kidney</topic><topic>Kidney - cytology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Medical sciences</topic><topic>Mononuclear cells</topic><topic>Neonates</topic><topic>Nephropathy</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>pH effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive oxygen species</topic><topic>Streptozocin</topic><topic>Trigonelline</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghule, Arvindkumar E.</creatorcontrib><creatorcontrib>Jadhav, Suresh S.</creatorcontrib><creatorcontrib>Bodhankar, Subhash L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghule, Arvindkumar E.</au><au>Jadhav, Suresh S.</au><au>Bodhankar, Subhash L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>14</volume><issue>4</issue><spage>740</spage><epage>748</epage><pages>740-748</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Oxidative stress and apoptotic cell death in kidney have been suggested as contributing factors in the development and complication of diabetes especially in diabetic nephropathy (DN). This study investigated the effects of trigonelline (TG) on the renal functional, morphological changes and renal apoptosis in neonatal diabetic rats, a model of non-insulin-dependent diabetes mellitus. Diabetes mellitus was induced in one day old neonatal Wistar rat pups by an intraperitoneal (i.p.) injection of streptozotocin (STZ) (50mg/kg) and monitored for 16weeks thereafter. The diabetic rats were divided as follows: the nSTZ diabetic group, the TG (50mg/kg) treated diabetic group, and the TG (100mg/kg) treated diabetic group. The age matched nondiabetic group received an injection of citrate buffer (0.1M, pH4.5). At the end kidney samples were taken for light microscopic examinations. The levels of serum creatinine and BUN were significantly low in TG (100mg/kg) treated diabetic rats. Glomerular filtration rate was improved in TG treated rats. The activities of antioxidant enzyme and membrane bound enzyme were decreased and the levels of tumor necrotic factor (TNF-α) and hydroxyproline content were increased in renal tissues of the diabetic group. TG (100mg/kg/day) treatment for a period of 4weeks showed significant ameliorative effects on all the biochemical parameters studied. Biochemical findings were supported by histological studies. The degenerative changes in kidney tissue and fibrosis were alleviated in the TG treated groups. These results suggested that TG might have a significant role in alleviating kidney damage in nSTZ-diabetic rats.
[Display omitted]
► Trigonelline (TG) is a plant hormone which is claimed to have antidiabetic and hypoglycemic activities. ► Oxidative stress and apoptosis play a central role in diabetic nephropathy. ► TG treatment ameliorates oxidative stress in mononuclear cells. ► Decreased apoptosis in renal cells confirmed the antiapoptotic role of trigonelline. ► Renal histology showed decreased tubular damage and fibrosis after TG treatment.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>23102665</pmid><doi>10.1016/j.intimp.2012.10.004</doi><tpages>9</tpages></addata></record> |
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| subjects | Alkaloids - pharmacology Animal models Animals Animals, Newborn Antioxidants Apoptosis Apoptosis - drug effects Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Glucose Cardiology. Vascular system Citric acid Creatinine Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - prevention & control Diabetes. Impaired glucose tolerance Diabetic Nephropathies - drug therapy Diabetic nephropathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Fibrosis Fibrosis - drug therapy Glomerular filtration rate Hydroxyproline Hypoglycemic Agents - pharmacology Insulin - blood Kidney Kidney - cytology Kidney - drug effects Kidney - metabolism Medical sciences Mononuclear cells Neonates Nephropathy Oxidative stress Oxidative Stress - drug effects pH effects Pharmacology. Drug treatments Rats Rats, Wistar Reactive oxygen species Streptozocin Trigonelline Tumors |
| title | Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats |
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