Increased brain uptake of docetaxel and ketoconazole loaded folate-grafted solid lipid nanoparticles

Abstract Docetaxel is used in the treatment of many types of cancer, but its entry into the brain is restricted by p-glycoprotein (p-gp) efflux. A potential drug–drug interaction exists between docetaxel and ketoconazole because both agents are metabolized hepatically by the cytochrome P-450 system,...

Ausführliche Beschreibung