A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis

► Human PBMCs were stimulated with various strains of heat-killed Bacteroides fragilis. ► B. fragilis has potent stimulatory effects on innate immunity. ► TLR1, TLR2 and NOD2 mediate pattern recognition of B. fragilis by human PBMCs. ► TLR4, TLR6, NOD1 and Dectin-1 were not involved in pattern recog...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2012-12, Vol.60 (3), p.861-869
Hauptverfasser:	Stappers, Mark H.T., Janssen, Nico A.F., Oosting, Marije, Plantinga, Theo S., Arvis, Pierre, Mouton, Johan W., Joosten, Leo A.B., Netea, Mihai G., Gyssens, Inge C.
Format:	Artikel
Sprache:	eng
Schlagworte:	abscess Abscesses Adult Aged Anaerobic Animals Bacteria Bacteroides fragilis Bacteroides fragilis - immunology Bacteroides Infections - immunology Bacteroides Infections - metabolism Base Sequence Cell Line CHO Cells Commensals Cricetinae Cytokines Cytokines - biosynthesis Cytokines - genetics Enzyme-linked immunosorbent assay Female genes Host response Humans Immune response Infection innate immunity Interleukin 10 Interleukin 17 Interleukin 23 Interleukin 6 Interleukin 8 Intestinal microflora intestinal microorganisms Intestine intracellular signaling peptides and proteins Lectins, C-Type - genetics Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - microbiology Male Microorganisms Middle Aged Nod1 protein NOD2 protein Nod2 Signaling Adaptor Protein - genetics Nod2 Signaling Adaptor Protein - metabolism Pattern recognition Polymorphism, Single Nucleotide Receptors Sequence Analysis, DNA Signal transduction Single-nucleotide polymorphism Soft tissues TLR1 protein TLR2 protein TLR4 protein Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - immunology Toll-Like Receptor 1 - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism Toll-like receptors Young Adult
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