SUMO1 modulates A[beta] generation via BACE1 accumulation

Accumulation of disease-related proteins is a characteristic event observed in the pathogenesis of neurodegenerative diseases. [beta]-secretase (BACE)-1, which initiates generation of [beta]-amyloid (A[beta]), is increased in the Alzheimer's diseased brain. However, the mechanisms of BACE1 accu...

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Veröffentlicht in:	Neurobiology of aging 2013-03, Vol.34 (3), p.650-662
Hauptverfasser:	Yun, Sang-Moon, Cho, Sun-Jung, Song, Jae Chun, Song, Sung Yeon, Jo, Sangmee Ahn, Jo, Chulman, Yoon, Keejung, Tanzi, Rudolph E, Choi, Eui-Ju, Koh, Young Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Amyloid precursor protein Apoptosis beta -Site APP cleaving enzyme 1 Brain C-Terminus Cortex Immunoreactivity Nervous system Neurodegenerative diseases SUMO protein Transgenic mice
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