TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155

TanshinoneIIA, an active component derived from a traditional Chinese medicine, has anti-inflammatory and anti-cancer effect. However, the mechanisms underlying the interaction between anti-inflammation and anti-cancer of TanshinoneIIA remain elusive. In the present study, a cell model of inflammati...

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Veröffentlicht in:	International immunopharmacology 2012-12, Vol.14 (4), p.353-361
Hauptverfasser:	Tu, Jiajie, Xing, Yingying, Guo, Yongjian, Tang, Feng, Guo, Le, Xi, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin Biological and medical sciences Cell culture Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Colon cancer Colonic Neoplasms - pathology Conduction Diterpenes, Abietane - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation - drug effects Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation-related cancer Inositol Polyphosphate 5-Phosphatases Inositol-1,4,5-trisphosphate 5-phosphatase Interleukin 6 Lipopolysaccharides Lipopolysaccharides - toxicity Macrophages Macrophages - drug effects Macrophages - metabolism Medical sciences Mice MicroRNA-155 MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Structure Pharmacology. Drug treatments Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism PU.1 PU.1 protein RNA, Messenger - genetics RNA, Messenger - metabolism SHIP1 Stomach. Duodenum. Small intestine. Colon. Rectum. Anus TanshinoneIIA Traditional Chinese Medicine Transcription Tumor necrosis factor- alpha Tumors
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