Predisposing Factors of Posterior Reversible Encephalopathy Syndrome in Acute Childhood Leukemia
Abstract A retrospective chart review was performed on 19 patients aged
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| Veröffentlicht in: | Pediatric neurology 2012-12, Vol.47 (6), p.436-442 |
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| container_title | Pediatric neurology |
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| creator | Kim, Seong Joon, MD Im, Soo Ah, MD, PhD Lee, Jae Wook, MD Chung, Nak Gyun, MD, PhD Cho, Bin, MD, PhD Kim, Hack Ki, MD, PhD Lee, In Goo, MD, PhD |
| description | Abstract A retrospective chart review was performed on 19 patients aged |
| doi_str_mv | 10.1016/j.pediatrneurol.2012.07.011 |
| format | Article |
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Posterior reversible encephalopathy syndrome was most often observed during acute lymphoblastic leukemia induction chemotherapy (n = 9, 47.4%) and after hematopoietic stem cell transplantation (n = 8, 42.1%). Among eight patients with the complication of posterior reversible encephalopathy syndrome after hematopoietic stem cell transplantation, five (62.5%) had a history of hypertension. In contrast, among 11 patients with the complication of posterior reversible encephalopathy syndrome without hematopoietic stem cell transplantation, only one (9.1%) had a history of hypertension. Moreover, unlike other leukemia induction chemotherapy, posterior reversible encephalopathy syndrome developed only in patients who received acute lymphoblastic leukemia induction chemotherapy. Posterior reversible encephalopathy syndrome patients required long-term anticonvulsant therapy (n = 9, 50.0%) and manifested intractable seizures (n = 3, 16.7%). Sequelae were evident in long-term follow-up magnetic resonance images (n = 5, 26.3%). Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2012.07.011</identifier><identifier>PMID: 23127265</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Child, Preschool ; Electroencephalography ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Induction Chemotherapy - adverse effects ; Infant ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Pediatrics ; Posterior Leukoencephalopathy Syndrome - diagnosis ; Posterior Leukoencephalopathy Syndrome - etiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery ; Retrospective Studies</subject><ispartof>Pediatric neurology, 2012-12, Vol.47 (6), p.436-442</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-378001d7ef95ef1cad2f367e4484481f07d0ee84ff959af91375ed84c84f61cb3</citedby><cites>FETCH-LOGICAL-c501t-378001d7ef95ef1cad2f367e4484481f07d0ee84ff959af91375ed84c84f61cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pediatrneurol.2012.07.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26616038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23127265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Seong Joon, MD</creatorcontrib><creatorcontrib>Im, Soo Ah, MD, PhD</creatorcontrib><creatorcontrib>Lee, Jae Wook, MD</creatorcontrib><creatorcontrib>Chung, Nak Gyun, MD, PhD</creatorcontrib><creatorcontrib>Cho, Bin, MD, PhD</creatorcontrib><creatorcontrib>Kim, Hack Ki, MD, PhD</creatorcontrib><creatorcontrib>Lee, In Goo, MD, PhD</creatorcontrib><title>Predisposing Factors of Posterior Reversible Encephalopathy Syndrome in Acute Childhood Leukemia</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Abstract A retrospective chart review was performed on 19 patients aged <18 years who developed posterior reversible encephalopathy syndrome as a complication during treatment of acute childhood leukemia. Posterior reversible encephalopathy syndrome was most often observed during acute lymphoblastic leukemia induction chemotherapy (n = 9, 47.4%) and after hematopoietic stem cell transplantation (n = 8, 42.1%). Among eight patients with the complication of posterior reversible encephalopathy syndrome after hematopoietic stem cell transplantation, five (62.5%) had a history of hypertension. In contrast, among 11 patients with the complication of posterior reversible encephalopathy syndrome without hematopoietic stem cell transplantation, only one (9.1%) had a history of hypertension. Moreover, unlike other leukemia induction chemotherapy, posterior reversible encephalopathy syndrome developed only in patients who received acute lymphoblastic leukemia induction chemotherapy. Posterior reversible encephalopathy syndrome patients required long-term anticonvulsant therapy (n = 9, 50.0%) and manifested intractable seizures (n = 3, 16.7%). Sequelae were evident in long-term follow-up magnetic resonance images (n = 5, 26.3%). Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Induction Chemotherapy - adverse effects</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pediatrics</subject><subject>Posterior Leukoencephalopathy Syndrome - diagnosis</subject><subject>Posterior Leukoencephalopathy Syndrome - etiology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery</subject><subject>Retrospective Studies</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklGL1DAUhYso7rj6F6Qggi-t9zZtkyIIyzCrwoCLq88xk9w6mW2bmrQL8-9NmVHRF4VAIPnOuck9N0leIOQIWL8-5CMZqyY_0OxdlxeARQ48B8QHyQoFZ1mFFTxMViAEz0TTlBfJkxAOAFA1Rfk4uSgYFryoq1Xy9cZHszC6YIdv6bXSk_MhdW1648JE3jqffqJ78sHuOko3g6Zxrzo3qml_TG-Pg_Gup9QO6ZWeJ0rXe9uZvXMm3dJ8R71VT5NHreoCPTvvl8mX683n9fts-_Hdh_XVNtMV4JQxLgDQcGqbilrUyhQtqzmVpYgLW-AGiETZxvtGtQ0yXpERpY5HNeodu0xenXxH777PFCbZ26Cp69RAbg5y-TDHpgL2bxRLrFhdAY_omxOqvQvBUytHb3vljxJBLmnIg_wjDbmkIYHLmEZUPz8Xmnc9mV_an-2PwMszoIJWXevVoG34zdU11sBE5DYnjmIH7y15GbSlGIaxnvQkjbP_-aC3f_nozg42lr6jI4WDm_0QQ5IoQ9TI22WAlvnBAoDVINgPu-jF1A</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Kim, Seong Joon, MD</creator><creator>Im, Soo Ah, MD, PhD</creator><creator>Lee, Jae Wook, MD</creator><creator>Chung, Nak Gyun, MD, PhD</creator><creator>Cho, Bin, MD, PhD</creator><creator>Kim, Hack Ki, MD, PhD</creator><creator>Lee, In Goo, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20121201</creationdate><title>Predisposing Factors of Posterior Reversible Encephalopathy Syndrome in Acute Childhood Leukemia</title><author>Kim, Seong Joon, MD ; Im, Soo Ah, MD, PhD ; Lee, Jae Wook, MD ; Chung, Nak Gyun, MD, PhD ; Cho, Bin, MD, PhD ; Kim, Hack Ki, MD, PhD ; Lee, In Goo, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-378001d7ef95ef1cad2f367e4484481f07d0ee84ff959af91375ed84c84f61cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Humans</topic><topic>Induction Chemotherapy - adverse effects</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pediatrics</topic><topic>Posterior Leukoencephalopathy Syndrome - diagnosis</topic><topic>Posterior Leukoencephalopathy Syndrome - etiology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seong Joon, MD</creatorcontrib><creatorcontrib>Im, Soo Ah, MD, PhD</creatorcontrib><creatorcontrib>Lee, Jae Wook, MD</creatorcontrib><creatorcontrib>Chung, Nak Gyun, MD, PhD</creatorcontrib><creatorcontrib>Cho, Bin, MD, PhD</creatorcontrib><creatorcontrib>Kim, Hack Ki, MD, PhD</creatorcontrib><creatorcontrib>Lee, In Goo, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seong Joon, MD</au><au>Im, Soo Ah, MD, PhD</au><au>Lee, Jae Wook, MD</au><au>Chung, Nak Gyun, MD, PhD</au><au>Cho, Bin, MD, PhD</au><au>Kim, Hack Ki, MD, PhD</au><au>Lee, In Goo, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predisposing Factors of Posterior Reversible Encephalopathy Syndrome in Acute Childhood Leukemia</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>47</volume><issue>6</issue><spage>436</spage><epage>442</epage><pages>436-442</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Abstract A retrospective chart review was performed on 19 patients aged <18 years who developed posterior reversible encephalopathy syndrome as a complication during treatment of acute childhood leukemia. Posterior reversible encephalopathy syndrome was most often observed during acute lymphoblastic leukemia induction chemotherapy (n = 9, 47.4%) and after hematopoietic stem cell transplantation (n = 8, 42.1%). Among eight patients with the complication of posterior reversible encephalopathy syndrome after hematopoietic stem cell transplantation, five (62.5%) had a history of hypertension. In contrast, among 11 patients with the complication of posterior reversible encephalopathy syndrome without hematopoietic stem cell transplantation, only one (9.1%) had a history of hypertension. Moreover, unlike other leukemia induction chemotherapy, posterior reversible encephalopathy syndrome developed only in patients who received acute lymphoblastic leukemia induction chemotherapy. Posterior reversible encephalopathy syndrome patients required long-term anticonvulsant therapy (n = 9, 50.0%) and manifested intractable seizures (n = 3, 16.7%). Sequelae were evident in long-term follow-up magnetic resonance images (n = 5, 26.3%). Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23127265</pmid><doi>10.1016/j.pediatrneurol.2012.07.011</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Child Child, Preschool Electroencephalography Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hematopoietic Stem Cell Transplantation - adverse effects Humans Induction Chemotherapy - adverse effects Infant Male Medical sciences Nervous system (semeiology, syndromes) Neurology Pediatrics Posterior Leukoencephalopathy Syndrome - diagnosis Posterior Leukoencephalopathy Syndrome - etiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery Retrospective Studies |
| title | Predisposing Factors of Posterior Reversible Encephalopathy Syndrome in Acute Childhood Leukemia |
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