Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage
Abstract We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal–temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in...
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| Veröffentlicht in: | Epilepsy & behavior 2012-11, Vol.25 (3), p.397-400 |
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| creator | Liguori, C Marciani, M.G Albanese, M Massa, R Izzi, F Placidi, F Mercuri, N.B Romigi, A |
| description | Abstract We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal–temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000 mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity. |
| doi_str_mv | 10.1016/j.yebeh.2012.08.026 |
| format | Article |
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Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000 mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.</description><identifier>ISSN: 1525-5050</identifier><identifier>EISSN: 1525-5069</identifier><identifier>DOI: 10.1016/j.yebeh.2012.08.026</identifier><identifier>PMID: 23103317</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>aphasia ; Aphasia MRI DWI ; Brain ; Case reports ; Cortex (frontal) ; Cortex (motor) ; Cortex (temporal) ; Data processing ; Diffusion ; EEG ; Electroencephalography ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - etiology ; Etiracetam ; Excitotoxicity ; Frontal Lobe - pathology ; Humans ; Ictal spasticity ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Neuron Disease - complications ; Motor neurons ; Muscle Spasticity - diagnosis ; Muscle Spasticity - etiology ; Neurology ; Seizures ; spasticity ; Status epilepticus ; Temporal Lobe - pathology</subject><ispartof>Epilepsy & behavior, 2012-11, Vol.25 (3), p.397-400</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-f7d52ad1d792ec175dd78fad6a51aa3f502f02dd9c075f975e53b4cf31dd9ae43</citedby><cites>FETCH-LOGICAL-c447t-f7d52ad1d792ec175dd78fad6a51aa3f502f02dd9c075f975e53b4cf31dd9ae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1525505012005446$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23103317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liguori, C</creatorcontrib><creatorcontrib>Marciani, M.G</creatorcontrib><creatorcontrib>Albanese, M</creatorcontrib><creatorcontrib>Massa, R</creatorcontrib><creatorcontrib>Izzi, F</creatorcontrib><creatorcontrib>Placidi, F</creatorcontrib><creatorcontrib>Mercuri, N.B</creatorcontrib><creatorcontrib>Romigi, A</creatorcontrib><title>Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage</title><title>Epilepsy & behavior</title><addtitle>Epilepsy Behav</addtitle><description>Abstract We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal–temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000 mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.</description><subject>aphasia</subject><subject>Aphasia MRI DWI</subject><subject>Brain</subject><subject>Case reports</subject><subject>Cortex (frontal)</subject><subject>Cortex (motor)</subject><subject>Cortex (temporal)</subject><subject>Data processing</subject><subject>Diffusion</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - etiology</subject><subject>Etiracetam</subject><subject>Excitotoxicity</subject><subject>Frontal Lobe - pathology</subject><subject>Humans</subject><subject>Ictal spasticity</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Neuron Disease - complications</subject><subject>Motor neurons</subject><subject>Muscle Spasticity - diagnosis</subject><subject>Muscle Spasticity - etiology</subject><subject>Neurology</subject><subject>Seizures</subject><subject>spasticity</subject><subject>Status epilepticus</subject><subject>Temporal Lobe - pathology</subject><issn>1525-5050</issn><issn>1525-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFDEMhiMEou3CL0BCOXLZwU4mk50DSKgCilqJQ8s5yiYeyDJfJBnU_ffNsqWHXnqKYz2vLT1m7A1ChYDN-121py39qgSgqGBTgWiesVNUQq0VNO3zh1rBCTtLaQeAqCS-ZCdCIkiJ-pRdXs825eBC3nObuB15cNn2fLY5Uxy5X4jnidNtIaY83QbHl3mmyIfyi3ykJU6FsoP9Sa_Yi872iV7fvyv248vnm_OL9dX3r9_OP12tXV3rvO60V8J69LoV5FAr7_Wms76xCq2VnQLRgfC-daBV12pFSm5r10ksPUu1XLF3x7lznP4slLIZQnLU93akaUkGhRYalRbt0ygq1KBUsbFi8oi6OKUUqTNzDIONe4NgDsLNzvwTbg7CDWxMEV5Sb-8XLNuB_EPmv-ECfDgCVIz8DRRNcoFGRz5Ectn4KTyx4OOjvOvDGJztf9Oe0m5a4lhkGzSpZMz14eaHk6MAUHXdyDsGkadc</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Liguori, C</creator><creator>Marciani, M.G</creator><creator>Albanese, M</creator><creator>Massa, R</creator><creator>Izzi, F</creator><creator>Placidi, F</creator><creator>Mercuri, N.B</creator><creator>Romigi, A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20121101</creationdate><title>Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage</title><author>Liguori, C ; Marciani, M.G ; Albanese, M ; Massa, R ; Izzi, F ; Placidi, F ; Mercuri, N.B ; Romigi, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-f7d52ad1d792ec175dd78fad6a51aa3f502f02dd9c075f975e53b4cf31dd9ae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>aphasia</topic><topic>Aphasia MRI DWI</topic><topic>Brain</topic><topic>Case reports</topic><topic>Cortex (frontal)</topic><topic>Cortex (motor)</topic><topic>Cortex (temporal)</topic><topic>Data processing</topic><topic>Diffusion</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - etiology</topic><topic>Etiracetam</topic><topic>Excitotoxicity</topic><topic>Frontal Lobe - pathology</topic><topic>Humans</topic><topic>Ictal spasticity</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Neuron Disease - complications</topic><topic>Motor neurons</topic><topic>Muscle Spasticity - diagnosis</topic><topic>Muscle Spasticity - etiology</topic><topic>Neurology</topic><topic>Seizures</topic><topic>spasticity</topic><topic>Status epilepticus</topic><topic>Temporal Lobe - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liguori, C</creatorcontrib><creatorcontrib>Marciani, M.G</creatorcontrib><creatorcontrib>Albanese, M</creatorcontrib><creatorcontrib>Massa, R</creatorcontrib><creatorcontrib>Izzi, F</creatorcontrib><creatorcontrib>Placidi, F</creatorcontrib><creatorcontrib>Mercuri, N.B</creatorcontrib><creatorcontrib>Romigi, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Epilepsy & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liguori, C</au><au>Marciani, M.G</au><au>Albanese, M</au><au>Massa, R</au><au>Izzi, F</au><au>Placidi, F</au><au>Mercuri, N.B</au><au>Romigi, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage</atitle><jtitle>Epilepsy & behavior</jtitle><addtitle>Epilepsy Behav</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>25</volume><issue>3</issue><spage>397</spage><epage>400</epage><pages>397-400</pages><issn>1525-5050</issn><eissn>1525-5069</eissn><abstract>Abstract We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal–temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000 mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23103317</pmid><doi>10.1016/j.yebeh.2012.08.026</doi><tpages>4</tpages></addata></record> |
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| subjects | aphasia Aphasia MRI DWI Brain Case reports Cortex (frontal) Cortex (motor) Cortex (temporal) Data processing Diffusion EEG Electroencephalography Epilepsy Epilepsy - diagnosis Epilepsy - etiology Etiracetam Excitotoxicity Frontal Lobe - pathology Humans Ictal spasticity Magnetic Resonance Imaging Male Middle Aged Motor Neuron Disease - complications Motor neurons Muscle Spasticity - diagnosis Muscle Spasticity - etiology Neurology Seizures spasticity Status epilepticus Temporal Lobe - pathology |
| title | Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage |
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