Hydrogels for encapsulation of mammalian cells

In our attempt to prepare new hydrogels for cell encapsulation, we decided to use synthetic copolymers presuming that chemical bonds should bring better mechanical stability of capsules than electrostatic forces between polyanions and polycations in the so far predominantly used materials based on p...

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Veröffentlicht in:	Macromolecular symposia. 2001-07, Vol.172 (1), p.157-165
Hauptverfasser:	Lukas, Jaromir, Paleckova, Vera, Mokry, Jaroslav, Karbanova, Jana, Dvorankova, Barbora
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl acrylates Copolymerization Copolymers Encapsulation Ethyl alcohol Hydrogels Molecular weight Swelling
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creator	Lukas, Jaromir Paleckova, Vera Mokry, Jaroslav Karbanova, Jana Dvorankova, Barbora
description	In our attempt to prepare new hydrogels for cell encapsulation, we decided to use synthetic copolymers presuming that chemical bonds should bring better mechanical stability of capsules than electrostatic forces between polyanions and polycations in the so far predominantly used materials based on polyelectrolyte complexes. Two series of copolymers of 2‐hydroxyethyl methacrylate (HEMA) with alkyl acrylates (methacrylates) or N‐alkylacrylamides (methacrylamides) were prepared. The copolymers, prepared by solution copolymerization in ethanol, were characterized by swelling in water and PBS solution, viscometric molecular weight, and NMR analysis, and their encapsulation processability was tested. Their characteristics and the first biological tests are the subject of this paper.
doi_str_mv	10.1002/1521-3900(200107)172:1<157::AID-MASY157>3.0.CO;2-K
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subjects	Alkyl acrylates Copolymerization Copolymers Encapsulation Ethyl alcohol Hydrogels Molecular weight Swelling
title	Hydrogels for encapsulation of mammalian cells
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