Segmented Polyurethanes for Medical Applications: Synthesis, Characterization and in vitro Enzymatic Degradation Studies
Degradable segmented poly(ether‐ester‐urethanes) of variable segment chemistry and content were synthesized and characterized. Polycaprolactone diol, a series of poly(ether‐ester) block copolymers, and a diisocyanate giving non toxic degradation products were used to form the prepolymer. Cyclohexane...
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| Veröffentlicht in: | Macromolecular symposia. 2004-11, Vol.218 (1), p.261-272 |
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| container_title | Macromolecular symposia. |
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| creator | Ciardelli, Gianluca Rechichi, Alfonsina Cerrai, Piero Tricoli, Mario Barbani, Niccoletta Giusti, Paolo |
| description | Degradable segmented poly(ether‐ester‐urethanes) of variable segment chemistry and content were synthesized and characterized. Polycaprolactone diol, a series of poly(ether‐ester) block copolymers, and a diisocyanate giving non toxic degradation products were used to form the prepolymer. Cyclohexane dimethanol and a L–phenylalanine–based diester (Phe diester) were used as chain extenders. The influence of α‐chimotrypsin on the degradation was investigated by exposing the polymers to buffer and enzyme solutions for 12 days. The SEM, SEC, and gravimetric results showed that a significant erosion of the Phe diester containing polymer compared with the control polyurethane occurred in the presence of the enzyme but not in a normal buffer solution. |
| doi_str_mv | 10.1002/masy.200451427 |
| format | Article |
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Polycaprolactone diol, a series of poly(ether‐ester) block copolymers, and a diisocyanate giving non toxic degradation products were used to form the prepolymer. Cyclohexane dimethanol and a L–phenylalanine–based diester (Phe diester) were used as chain extenders. The influence of α‐chimotrypsin on the degradation was investigated by exposing the polymers to buffer and enzyme solutions for 12 days. The SEM, SEC, and gravimetric results showed that a significant erosion of the Phe diester containing polymer compared with the control polyurethane occurred in the presence of the enzyme but not in a normal buffer solution.</description><identifier>ISSN: 1022-1360</identifier><identifier>EISSN: 1521-3900</identifier><identifier>DOI: 10.1002/masy.200451427</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>block copolymer ; Degradation ; Diesters ; Diisocyanates ; Diols ; enzyme ; Enzymes ; film casting ; In vitro testing ; Medical ; Polyurethane resins ; polyurethanes</subject><ispartof>Macromolecular symposia., 2004-11, Vol.218 (1), p.261-272</ispartof><rights>Copyright © 2004 WILEY‐VCH Verlag GmbH & Co. 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The SEM, SEC, and gravimetric results showed that a significant erosion of the Phe diester containing polymer compared with the control polyurethane occurred in the presence of the enzyme but not in a normal buffer solution.</description><subject>block copolymer</subject><subject>Degradation</subject><subject>Diesters</subject><subject>Diisocyanates</subject><subject>Diols</subject><subject>enzyme</subject><subject>Enzymes</subject><subject>film casting</subject><subject>In vitro testing</subject><subject>Medical</subject><subject>Polyurethane resins</subject><subject>polyurethanes</subject><issn>1022-1360</issn><issn>1521-3900</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkM1P3DAQxSNUpFLaa88-9tAsM3ayJr2tlm8BrbStqp4sx56wbvOx2F4g_PWYBqHeepqnmfcbzbws-4gwQwB-0OkwzjhAUWLB5U62hyXHXFQAb5IGznMUc3ibvQvhNwBUlcS97GFFNx31kSz7NrTj1lNc654CawbPrsg6o1u22GzaJKIb-vCFrcY-rim48Jkt19prE8m7x79TpnvLXM_uXPQDO-4fxy71DTuiG6_tZFnFrXUU3me7jW4DfXip-9mPk-Pvy7P88uvp-XJxmZt0rMyFbVCiqUu0Bg00cKhJcySkRpZaclMbgYUo0NbpXVEDioLQ6pLqyiRM7Gefpr0bP9xuKUTVuWCobdOXwzYo5PO5LHhRiGSdTVbjhxA8NWrjXaf9qBDUc8TqOWL1GnECqgm4dy2N_3Grq8Xq179sPrEuRHp4ZbX_o-ZSyFL9vD5VF4BHZycg1LV4AiS2kkg</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Ciardelli, Gianluca</creator><creator>Rechichi, Alfonsina</creator><creator>Cerrai, Piero</creator><creator>Tricoli, Mario</creator><creator>Barbani, Niccoletta</creator><creator>Giusti, Paolo</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>200411</creationdate><title>Segmented Polyurethanes for Medical Applications: Synthesis, Characterization and in vitro Enzymatic Degradation Studies</title><author>Ciardelli, Gianluca ; Rechichi, Alfonsina ; Cerrai, Piero ; Tricoli, Mario ; Barbani, Niccoletta ; Giusti, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3607-3df171cb51dc1c0f08aea21e1ef75a72cbc314341db1523b0134e1da5eb9ccb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>block copolymer</topic><topic>Degradation</topic><topic>Diesters</topic><topic>Diisocyanates</topic><topic>Diols</topic><topic>enzyme</topic><topic>Enzymes</topic><topic>film casting</topic><topic>In vitro testing</topic><topic>Medical</topic><topic>Polyurethane resins</topic><topic>polyurethanes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciardelli, Gianluca</creatorcontrib><creatorcontrib>Rechichi, Alfonsina</creatorcontrib><creatorcontrib>Cerrai, Piero</creatorcontrib><creatorcontrib>Tricoli, Mario</creatorcontrib><creatorcontrib>Barbani, Niccoletta</creatorcontrib><creatorcontrib>Giusti, Paolo</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Macromolecular symposia.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciardelli, Gianluca</au><au>Rechichi, Alfonsina</au><au>Cerrai, Piero</au><au>Tricoli, Mario</au><au>Barbani, Niccoletta</au><au>Giusti, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Segmented Polyurethanes for Medical Applications: Synthesis, Characterization and in vitro Enzymatic Degradation Studies</atitle><jtitle>Macromolecular symposia.</jtitle><addtitle>Macromol. 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| subjects | block copolymer Degradation Diesters Diisocyanates Diols enzyme Enzymes film casting In vitro testing Medical Polyurethane resins polyurethanes |
| title | Segmented Polyurethanes for Medical Applications: Synthesis, Characterization and in vitro Enzymatic Degradation Studies |
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