Raman spectroscopy of topiramate under high pressure conditions

Topiramate is a white crystalline solid with powerful anticonvulsant activity and is used to treat epilepsy. Drug manufacturing involves various physical and chemical processes, which may lead to the formation of an unexpected, or undesired, crystalline phase, in a phenomenon known as polymorphism....

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Veröffentlicht in:	Journal of Raman spectroscopy 2010-03, Vol.41 (3), p.356-359
Hauptverfasser:	Sena Jr, Diniz M., Freire, Paulo T. C., Filho, Josué M., Melo, Francisco E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetry Compressing Crystal structure Crystals high pressure Hydrogen bonds organic crystals Phase change polymorphism Raman spectroscopy Running strain topiramate
Online-Zugang:	Volltext
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