Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progre...
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| Veröffentlicht in: | Cancer biotherapy & radiopharmaceuticals 2012-11, Vol.27 (9), p.606-613 |
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| container_title | Cancer biotherapy & radiopharmaceuticals |
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| creator | Zhao, Wenxiu Ren, Guangli Zhang, Lei Zhang, Zhengqi Liu, Jianming Kuang, Penghao Yin, Zhenyu Wang, Xiaomin |
| description | Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available. |
| doi_str_mv | 10.1089/cbr.2011.1150 |
| format | Article |
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The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available.</description><identifier>ISSN: 1084-9785</identifier><identifier>EISSN: 1557-8852</identifier><identifier>DOI: 10.1089/cbr.2011.1150</identifier><identifier>PMID: 22917212</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adipose tissue ; Adipose Tissue - chemistry ; Adipose Tissue - cytology ; Adipose Tissue - metabolism ; AKT protein ; Apoptosis ; Body fat ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell death ; Cell Growth Processes - drug effects ; Cell Line, Tumor ; Cell proliferation ; Cells, Cultured ; Culture Media - pharmacology ; Hepatocellular carcinoma ; Humans ; Liver Neoplasms - drug therapy ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Malignancy ; Mesenchymal Stromal Cells - chemistry ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mesenchyme ; Pharmaceuticals ; Radioisotopes ; Stem cells</subject><ispartof>Cancer biotherapy & radiopharmaceuticals, 2012-11, Vol.27 (9), p.606-613</ispartof><rights>(©) Copyright 2012, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-1aad1c35b34ac77b33875c08f152514692cc5d0662e98556f17f5b801120fe5e3</citedby><cites>FETCH-LOGICAL-c354t-1aad1c35b34ac77b33875c08f152514692cc5d0662e98556f17f5b801120fe5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22917212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Wenxiu</creatorcontrib><creatorcontrib>Ren, Guangli</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Zhang, Zhengqi</creatorcontrib><creatorcontrib>Liu, Jianming</creatorcontrib><creatorcontrib>Kuang, Penghao</creatorcontrib><creatorcontrib>Yin, Zhenyu</creatorcontrib><creatorcontrib>Wang, Xiaomin</creatorcontrib><title>Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro</title><title>Cancer biotherapy & radiopharmaceuticals</title><addtitle>Cancer Biother Radiopharm</addtitle><description>Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and over the past several decades, many researchers have worked to develop novel effective therapies for HCC patients. The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - chemistry</subject><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - metabolism</subject><subject>AKT protein</subject><subject>Apoptosis</subject><subject>Body fat</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell death</subject><subject>Cell Growth Processes - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cells, Cultured</subject><subject>Culture Media - pharmacology</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Malignancy</subject><subject>Mesenchymal Stromal Cells - chemistry</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Pharmaceuticals</subject><subject>Radioisotopes</subject><subject>Stem cells</subject><issn>1084-9785</issn><issn>1557-8852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkT1r3TAUhkVpaD7asWsRdOniGx3Zx5LHEtKkEOjSzkaWj7gKlnUr2YE79L9HJrcdshQEeodHLzrnYewjiB0I3V3bIe2kANgBoHjDLgBRVVqjfFuy0E3VKY3n7DLnRyFEK1r1jp1L2YGSIC_Yn1vnvDX2yKPjgTLNdn8MZuJ5ocAtTVPmIyX_RCN3KQa-X4OZuRn9IWbii895Je7ncvZ-8IuP89a0p4NZ4vZ8nUzi1iTr5xjMqbHwT35J8T07c2bK9OF0X7Ff325_3txXDz_uvt98fahsjc1SgTEjlDjUjbFKDXWtFVqhHaBEaNpOWoujaFtJnUZsHSiHgy5bkcIRUn3Fvrz0HlL8vVJe-uDz9hUzU1xzDxKVUlq38v8oyBZVp6Uq6OdX6GNc01wG2ahGSoVQF6p6oWyKOSdy_SH5YNKxB9FvCvuisN8U9pvCwn86ta5DoPEf_ddZ_QxgI5cV</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Zhao, Wenxiu</creator><creator>Ren, Guangli</creator><creator>Zhang, Lei</creator><creator>Zhang, Zhengqi</creator><creator>Liu, Jianming</creator><creator>Kuang, Penghao</creator><creator>Yin, Zhenyu</creator><creator>Wang, Xiaomin</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201211</creationdate><title>Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro</title><author>Zhao, Wenxiu ; Ren, Guangli ; Zhang, Lei ; Zhang, Zhengqi ; Liu, Jianming ; Kuang, Penghao ; Yin, Zhenyu ; Wang, Xiaomin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-1aad1c35b34ac77b33875c08f152514692cc5d0662e98556f17f5b801120fe5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - 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The functional contributions of mesenchymal stem cells to human malignancies, including HCC growth and progression, are controversial, and the potential mechanisms underlying these effects are not clear. The aim of this study was to investigate the effect of adipose-derived mesenchymal stem cells (ADSCs) on the growth of HCC cells. In this study, a conditioned medium from ADSCs (ADSC-CM) efficiently inhibited HCC cell proliferation and division, and induced HCC cell death through the downregulation of Akt signaling. These findings indicated that the ADSC-CM could inhibit HCC growth. Thus, the ADSC-CM is a good candidate for the treatment of HCC patients for whom no effective therapy is available.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>22917212</pmid><doi>10.1089/cbr.2011.1150</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer biotherapy & radiopharmaceuticals, 2012-11, Vol.27 (9), p.606-613 |
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| subjects | Adipose tissue Adipose Tissue - chemistry Adipose Tissue - cytology Adipose Tissue - metabolism AKT protein Apoptosis Body fat Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell death Cell Growth Processes - drug effects Cell Line, Tumor Cell proliferation Cells, Cultured Culture Media - pharmacology Hepatocellular carcinoma Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Malignancy Mesenchymal Stromal Cells - chemistry Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Pharmaceuticals Radioisotopes Stem cells |
| title | Efficacy of mesenchymal stem cells derived from human adipose tissue in inhibition of hepatocellular carcinoma cells in vitro |
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