Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis
Background A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of proph...
Gespeichert in:
| Veröffentlicht in: | Acta neurochirurgica 2012-12, Vol.154 (12), p.2241-2249 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2249 |
|---|---|
| container_issue | 12 |
| container_start_page | 2241 |
| container_title | Acta neurochirurgica |
| container_volume | 154 |
| creator | Hamasaki, Tadashi Yamada, Kazumichi Yano, Shigetoshi Nakamura, Hideo Makino, Keishi Hide, Taku-ichiro Hasegawa, Yu Kuroda, Jun-ichiro Hirai, Toshinori Kuratsu, Jun-ichi |
| description | Background
A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of prophylactic anti-epileptic drugs (AEDs) to abort tumor-associated epilepsy as a whole.
Methods
To investigate the relationship between tumor location and incidence of epilepsy, we performed voxel-wise comparison between 3D MRI scans obtained from patients with meningioma-associated epilepsy and those from control patients using spatial normalization techniques on neuroimaging data. Variables such as age, tumor size, the degree of edema, and pathological diagnosis were also compared between the two groups.
Results
Our results showed the highest incidence of epilepsy when the tumor was located on the premotor cortex in the frontal lobe (Z-scores >2.0, Liebermeister’s quasi-exact test). The stepwise multiple regression analysis on the clinical data revealed that the tumor diameter (
p
|
| doi_str_mv | 10.1007/s00701-012-1511-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1257764334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2818759001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-d6170fb762e0aab22b943d050c0cb6bf6b258e6952d6d73bd0554edcc6e496673</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhS1URMvCD-CCLPXSS2DsxPamt6oqFKkSFzhbjjPZukri4PG23X-Ply0IVUJcxva8b541eoy9E_BBAJiPVAqICoSshBKiEi_YCbSNrEqBo3KHomqp18fsNdFdeUnT1K_YsaxhrQWoEzZdh80tJh5mH3qcPfI4cFzCiAvtSpdPOId5E-LkiI_Ru4w9jzPPt8iXhFPMMXEfU8bHc-74fXzEsXoIhJyyy4Fy8G7kbnbjjgK9YS8HNxK-fTpX7Punq2-X19XN189fLi9uKt8YkateCwNDZ7REcK6TsmubugcFHnynu0F3Uq1Rt0r2ujd1VyTVYO-9xqbV2tQrdnbwXVL8sUXKdgrkcRzdjHFLVkhljG7quvk_KsxaayVg73r6DL2L21RW-0WBku3ecsXEgfIpEiUc7JLC5NLOCrD72OwhNlvSsPvYrCgz75-ct92E_Z-J3zkVQB4AKtK8wfTX1_90_QkJmaJV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1170529643</pqid></control><display><type>article</type><title>Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Hamasaki, Tadashi ; Yamada, Kazumichi ; Yano, Shigetoshi ; Nakamura, Hideo ; Makino, Keishi ; Hide, Taku-ichiro ; Hasegawa, Yu ; Kuroda, Jun-ichiro ; Hirai, Toshinori ; Kuratsu, Jun-ichi</creator><creatorcontrib>Hamasaki, Tadashi ; Yamada, Kazumichi ; Yano, Shigetoshi ; Nakamura, Hideo ; Makino, Keishi ; Hide, Taku-ichiro ; Hasegawa, Yu ; Kuroda, Jun-ichiro ; Hirai, Toshinori ; Kuratsu, Jun-ichi</creatorcontrib><description>Background
A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of prophylactic anti-epileptic drugs (AEDs) to abort tumor-associated epilepsy as a whole.
Methods
To investigate the relationship between tumor location and incidence of epilepsy, we performed voxel-wise comparison between 3D MRI scans obtained from patients with meningioma-associated epilepsy and those from control patients using spatial normalization techniques on neuroimaging data. Variables such as age, tumor size, the degree of edema, and pathological diagnosis were also compared between the two groups.
Results
Our results showed the highest incidence of epilepsy when the tumor was located on the premotor cortex in the frontal lobe (Z-scores >2.0, Liebermeister’s quasi-exact test). The stepwise multiple regression analysis on the clinical data revealed that the tumor diameter (
p
< 0.001) and the patient’s age (
p
= 0.024) were positive and negative predictors, respectively, for the onset of epilepsy.
Conclusions
The incidence of epilepsy was higher in meningiomas located on the premotor cortex than on the other cortex. Larger volume also contributed to the onset of epilepsy. We suggest that variations of epilepsy incidence dependent on tumor characteristics can be considered when treating tumor-associated epilepsy.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-012-1511-1</identifier><identifier>PMID: 23086105</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adult ; Age ; Aged ; Brain Neoplasms - complications ; Brain Neoplasms - pathology ; Brain tumors ; Cerebral Cortex - pathology ; Clinical Article ; Cortex (frontal) ; Cortex (premotor) ; Data processing ; Drugs ; Edema ; Epilepsy ; Epilepsy - epidemiology ; Epilepsy - pathology ; Female ; Frontal lobe ; Humans ; Incidence ; Interventional Radiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Meningeal Neoplasms - pathology ; meningioma ; Meningioma - complications ; Meningioma - pathology ; Middle Aged ; Minimally Invasive Surgery ; Multiple regression analysis ; Neuroimaging ; Neuroimaging - methods ; Neurology ; Neuroradiology ; Neurosurgery ; Reviews ; Seizures ; Statistical analysis ; Surgical Orthopedics ; Treatment Outcome</subject><ispartof>Acta neurochirurgica, 2012-12, Vol.154 (12), p.2241-2249</ispartof><rights>Springer-Verlag Wien 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-d6170fb762e0aab22b943d050c0cb6bf6b258e6952d6d73bd0554edcc6e496673</citedby><cites>FETCH-LOGICAL-c471t-d6170fb762e0aab22b943d050c0cb6bf6b258e6952d6d73bd0554edcc6e496673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-012-1511-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-012-1511-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23086105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamasaki, Tadashi</creatorcontrib><creatorcontrib>Yamada, Kazumichi</creatorcontrib><creatorcontrib>Yano, Shigetoshi</creatorcontrib><creatorcontrib>Nakamura, Hideo</creatorcontrib><creatorcontrib>Makino, Keishi</creatorcontrib><creatorcontrib>Hide, Taku-ichiro</creatorcontrib><creatorcontrib>Hasegawa, Yu</creatorcontrib><creatorcontrib>Kuroda, Jun-ichiro</creatorcontrib><creatorcontrib>Hirai, Toshinori</creatorcontrib><creatorcontrib>Kuratsu, Jun-ichi</creatorcontrib><title>Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of prophylactic anti-epileptic drugs (AEDs) to abort tumor-associated epilepsy as a whole.
Methods
To investigate the relationship between tumor location and incidence of epilepsy, we performed voxel-wise comparison between 3D MRI scans obtained from patients with meningioma-associated epilepsy and those from control patients using spatial normalization techniques on neuroimaging data. Variables such as age, tumor size, the degree of edema, and pathological diagnosis were also compared between the two groups.
Results
Our results showed the highest incidence of epilepsy when the tumor was located on the premotor cortex in the frontal lobe (Z-scores >2.0, Liebermeister’s quasi-exact test). The stepwise multiple regression analysis on the clinical data revealed that the tumor diameter (
p
< 0.001) and the patient’s age (
p
= 0.024) were positive and negative predictors, respectively, for the onset of epilepsy.
Conclusions
The incidence of epilepsy was higher in meningiomas located on the premotor cortex than on the other cortex. Larger volume also contributed to the onset of epilepsy. We suggest that variations of epilepsy incidence dependent on tumor characteristics can be considered when treating tumor-associated epilepsy.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumors</subject><subject>Cerebral Cortex - pathology</subject><subject>Clinical Article</subject><subject>Cortex (frontal)</subject><subject>Cortex (premotor)</subject><subject>Data processing</subject><subject>Drugs</subject><subject>Edema</subject><subject>Epilepsy</subject><subject>Epilepsy - epidemiology</subject><subject>Epilepsy - pathology</subject><subject>Female</subject><subject>Frontal lobe</subject><subject>Humans</subject><subject>Incidence</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningeal Neoplasms - pathology</subject><subject>meningioma</subject><subject>Meningioma - complications</subject><subject>Meningioma - pathology</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgery</subject><subject>Multiple regression analysis</subject><subject>Neuroimaging</subject><subject>Neuroimaging - methods</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Reviews</subject><subject>Seizures</subject><subject>Statistical analysis</subject><subject>Surgical Orthopedics</subject><subject>Treatment Outcome</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUFv1DAQhS1URMvCD-CCLPXSS2DsxPamt6oqFKkSFzhbjjPZukri4PG23X-Ply0IVUJcxva8b541eoy9E_BBAJiPVAqICoSshBKiEi_YCbSNrEqBo3KHomqp18fsNdFdeUnT1K_YsaxhrQWoEzZdh80tJh5mH3qcPfI4cFzCiAvtSpdPOId5E-LkiI_Ru4w9jzPPt8iXhFPMMXEfU8bHc-74fXzEsXoIhJyyy4Fy8G7kbnbjjgK9YS8HNxK-fTpX7Punq2-X19XN189fLi9uKt8YkateCwNDZ7REcK6TsmubugcFHnynu0F3Uq1Rt0r2ujd1VyTVYO-9xqbV2tQrdnbwXVL8sUXKdgrkcRzdjHFLVkhljG7quvk_KsxaayVg73r6DL2L21RW-0WBku3ecsXEgfIpEiUc7JLC5NLOCrD72OwhNlvSsPvYrCgz75-ct92E_Z-J3zkVQB4AKtK8wfTX1_90_QkJmaJV</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Hamasaki, Tadashi</creator><creator>Yamada, Kazumichi</creator><creator>Yano, Shigetoshi</creator><creator>Nakamura, Hideo</creator><creator>Makino, Keishi</creator><creator>Hide, Taku-ichiro</creator><creator>Hasegawa, Yu</creator><creator>Kuroda, Jun-ichiro</creator><creator>Hirai, Toshinori</creator><creator>Kuratsu, Jun-ichi</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis</title><author>Hamasaki, Tadashi ; Yamada, Kazumichi ; Yano, Shigetoshi ; Nakamura, Hideo ; Makino, Keishi ; Hide, Taku-ichiro ; Hasegawa, Yu ; Kuroda, Jun-ichiro ; Hirai, Toshinori ; Kuratsu, Jun-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-d6170fb762e0aab22b943d050c0cb6bf6b258e6952d6d73bd0554edcc6e496673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain tumors</topic><topic>Cerebral Cortex - pathology</topic><topic>Clinical Article</topic><topic>Cortex (frontal)</topic><topic>Cortex (premotor)</topic><topic>Data processing</topic><topic>Drugs</topic><topic>Edema</topic><topic>Epilepsy</topic><topic>Epilepsy - epidemiology</topic><topic>Epilepsy - pathology</topic><topic>Female</topic><topic>Frontal lobe</topic><topic>Humans</topic><topic>Incidence</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningeal Neoplasms - pathology</topic><topic>meningioma</topic><topic>Meningioma - complications</topic><topic>Meningioma - pathology</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgery</topic><topic>Multiple regression analysis</topic><topic>Neuroimaging</topic><topic>Neuroimaging - methods</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Reviews</topic><topic>Seizures</topic><topic>Statistical analysis</topic><topic>Surgical Orthopedics</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamasaki, Tadashi</creatorcontrib><creatorcontrib>Yamada, Kazumichi</creatorcontrib><creatorcontrib>Yano, Shigetoshi</creatorcontrib><creatorcontrib>Nakamura, Hideo</creatorcontrib><creatorcontrib>Makino, Keishi</creatorcontrib><creatorcontrib>Hide, Taku-ichiro</creatorcontrib><creatorcontrib>Hasegawa, Yu</creatorcontrib><creatorcontrib>Kuroda, Jun-ichiro</creatorcontrib><creatorcontrib>Hirai, Toshinori</creatorcontrib><creatorcontrib>Kuratsu, Jun-ichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamasaki, Tadashi</au><au>Yamada, Kazumichi</au><au>Yano, Shigetoshi</au><au>Nakamura, Hideo</au><au>Makino, Keishi</au><au>Hide, Taku-ichiro</au><au>Hasegawa, Yu</au><au>Kuroda, Jun-ichiro</au><au>Hirai, Toshinori</au><au>Kuratsu, Jun-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>154</volume><issue>12</issue><spage>2241</spage><epage>2249</epage><pages>2241-2249</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Background
A substantial number of patients with brain tumors develop recurrent seizures, known as tumor-associated epilepsy. It is important to identify specific subgroups of brain tumor patients with higher incidences of epilepsy because a meta-analysis failed to certify the effectiveness of prophylactic anti-epileptic drugs (AEDs) to abort tumor-associated epilepsy as a whole.
Methods
To investigate the relationship between tumor location and incidence of epilepsy, we performed voxel-wise comparison between 3D MRI scans obtained from patients with meningioma-associated epilepsy and those from control patients using spatial normalization techniques on neuroimaging data. Variables such as age, tumor size, the degree of edema, and pathological diagnosis were also compared between the two groups.
Results
Our results showed the highest incidence of epilepsy when the tumor was located on the premotor cortex in the frontal lobe (Z-scores >2.0, Liebermeister’s quasi-exact test). The stepwise multiple regression analysis on the clinical data revealed that the tumor diameter (
p
< 0.001) and the patient’s age (
p
= 0.024) were positive and negative predictors, respectively, for the onset of epilepsy.
Conclusions
The incidence of epilepsy was higher in meningiomas located on the premotor cortex than on the other cortex. Larger volume also contributed to the onset of epilepsy. We suggest that variations of epilepsy incidence dependent on tumor characteristics can be considered when treating tumor-associated epilepsy.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>23086105</pmid><doi>10.1007/s00701-012-1511-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6268 |
| ispartof | Acta neurochirurgica, 2012-12, Vol.154 (12), p.2241-2249 |
| issn | 0001-6268 0942-0940 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1257764334 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Age Aged Brain Neoplasms - complications Brain Neoplasms - pathology Brain tumors Cerebral Cortex - pathology Clinical Article Cortex (frontal) Cortex (premotor) Data processing Drugs Edema Epilepsy Epilepsy - epidemiology Epilepsy - pathology Female Frontal lobe Humans Incidence Interventional Radiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Meningeal Neoplasms - pathology meningioma Meningioma - complications Meningioma - pathology Middle Aged Minimally Invasive Surgery Multiple regression analysis Neuroimaging Neuroimaging - methods Neurology Neuroradiology Neurosurgery Reviews Seizures Statistical analysis Surgical Orthopedics Treatment Outcome |
| title | Higher incidence of epilepsy in meningiomas located on the premotor cortex: a voxel-wise statistical analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T12%3A31%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Higher%20incidence%20of%20epilepsy%20in%20meningiomas%20located%20on%20the%20premotor%20cortex:%20a%20voxel-wise%20statistical%20analysis&rft.jtitle=Acta%20neurochirurgica&rft.au=Hamasaki,%20Tadashi&rft.date=2012-12-01&rft.volume=154&rft.issue=12&rft.spage=2241&rft.epage=2249&rft.pages=2241-2249&rft.issn=0001-6268&rft.eissn=0942-0940&rft_id=info:doi/10.1007/s00701-012-1511-1&rft_dat=%3Cproquest_cross%3E2818759001%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1170529643&rft_id=info:pmid/23086105&rfr_iscdi=true |