An immobilized and reusable Cu(I) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction

Chelation of Cu(I) ions to an immobilized hydrophilic tris(triazolylmethyl)amine chelator on a solid support allowed synthesis of RNA oligonucleotide conjugates from completely deprotected alkyne-oligonucleotides. No oligonucleotide strand degradation or metal ion contamination was observed. Further...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (2), p.184-186
Hauptverfasser:	Eltepu, Laxman, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Manoharan, Muthiah
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Azides - chemistry Catalysis Chelating Agents - chemistry Click Chemistry Copper - chemistry Ions - chemistry Ligands Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Polystyrenes - chemistry Stereoisomerism
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