Apicoplast triose phosphate transporter (TPT) gene knockout is lethal for Plasmodium

[Display omitted] ► Plasmodium berghei triose phosphate transporter (TPT) knockout parasites (KO) fail to survive. ► P. berghei phosphoenolpyruvate transporter (PPT) KO behave similar to the wild type in blood stage parasite. ► PPT-KO shows defects in sporozoite and liverstage parasite development....

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Veröffentlicht in:	Molecular and biochemical parasitology 2012-11, Vol.186 (1), p.44-50
Hauptverfasser:	Banerjee, Tanushree, Jaijyan, Dabbu Kumar, Surolia, Namita, Singh, Agam Prasad, Surolia, Avadhesha
Format:	Artikel
Sprache:	eng
Schlagworte:	Apicoplast triose phosphate transporter blood groups carbon Cell Survival Culicidae energy Gene Knockout Techniques gene targeting Genes, Essential Knockout Lipoylation liver Organelles - enzymology Organelles - genetics Organelles - physiology P. berghei parasites parasitology Phosphate Transport Proteins - genetics Phosphate Transport Proteins - metabolism Phosphoenolpyruvate transporter Plasmodium berghei Plasmodium berghei - enzymology Plasmodium berghei - genetics Plasmodium berghei - physiology Pyruvate dehydrogenase Sugar Phosphates - metabolism sugars transporters Trioses - metabolism
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