Lysine-71 in the large delta antigen of hepatitis delta virus clade 3 modulates its localization and secretion

► The large delta antigen of HDV (LD) fused with GFP demonstrates its dynamic cellular localizations. ► Pattern and cellular distribution of LD from HDV clade 1 and 3 is different. ► Deacetylation of LD facilitates its targeting to the cytoplasm and co-secretion with HBsAg. Hepatitis delta virus (HD...

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Veröffentlicht in:	Virus research 2012-12, Vol.170 (1-2), p.75-84
Hauptverfasser:	Huang, Chi-Ruei, Wang, Robert Y.L., Hsu, Sheng-Chieh, Lo, Szecheng J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetylation/deacetylation Amino acid sequence amino acids Cell Line Cell Nucleus - metabolism Cytoplasm fluorescence Genes, Reporter Genotype HDV clade 3 Hepatitis Hepatitis B Surface Antigens - metabolism Hepatitis D virus Hepatitis delta Antigens - chemistry Hepatitis delta Antigens - genetics Hepatitis delta Antigens - metabolism Hepatitis delta virus Hepatitis Delta Virus - physiology Histone acetyltransferase Histone deacetylase Histone deacetylase (HDAC) Histones - metabolism Humans Infection Large delta antigen Lysine mutants Nuclei Nucleotide sequence p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism Phosphorylation Post-translation post-translational modification protein secretion Protein Transport RNA RNA viruses Secretion sequence alignment Time Factors Transfection virion Virus Release viruses Western blotting
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