Imatinib increases apoptosis index through modulation of survivin subcellular localization in the blast phase of CML cells

Abstract Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell lin...

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Veröffentlicht in:	Leukemia research 2012-12, Vol.36 (12), p.1510-1516
Hauptverfasser:	Bernardo, Paula Sabbo, Reis, Flaviana Ruade de Souza, Maia, Raquel Ciuvalschi
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A5 - metabolism Annexin V Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Benzamides Blast Blast Crisis - drug therapy Blast Crisis - genetics Blast Crisis - pathology Blotting, Western Cell Nucleus - metabolism Cell Nucleus - pathology Cell Survival - drug effects Chronic myeloid leukemia Cytoplasm - metabolism Cytoplasm - pathology Flow Cytometry Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Imatinib Imatinib Mesylate Immunocytochemistry Immunohistochemistry Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Nuclei P-Glycoprotein Piperazines - pharmacology Pyrimidines - pharmacology Subcellular localization Survivin Tumor cell lines Western blotting
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