p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma
Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a well-established association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cel...
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| Veröffentlicht in: | Modern pathology 2012-11, Vol.25 (11), p.1526-1533 |
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| creator | Alexander, Riley E Hu, Yingchuan Kum, Jennifer B Montironi, Rodolfo Lopez-Beltran, Antonio MacLennan, Gregory T Idrees, Muhammad T Emerson, Robert E Ulbright, Thomas M Grignon, David G Eble, John N Cheng, Liang |
| description | Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a well-established association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cell carcinoma of the urinary bladder is uncertain. The purposes of this study were to investigate the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy. In all, 42 cases of squamous cell carcinoma of the urinary bladder and 27 cases of urothelial carcinoma with squamous differentiation were investigated. HPV infection was analyzed by both
in situ
hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms. |
| doi_str_mv | 10.1038/modpathol.2012.103 |
| format | Article |
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in situ
hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2012.103</identifier><identifier>PMID: 22684221</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/199 ; 692/699/255/2514 ; 692/699/67/589/1336 ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Bladder cancer ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - virology ; Cell Differentiation ; Cervix ; Cyclin-Dependent Kinase Inhibitor p16 - analysis ; Data processing ; Differentiation ; DNA ; DNA, Viral - analysis ; Etiology ; Female ; Head ; Histology ; Human papillomavirus ; Human Papillomavirus DNA Tests ; Humans ; Hybridization ; Immunohistochemistry ; In Situ Hybridization ; Infection ; Infections ; Keratin ; Laboratory Medicine ; Male ; Malignancy ; Medicine ; Medicine & Public Health ; Middle Aged ; Monoclonal antibodies ; Neck ; original-article ; p16 protein ; Papillomaviridae - genetics ; Papillomavirus Infections - complications ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - virology ; Pathogenesis ; Pathology ; Predictive Value of Tests ; Proteins ; Risk Factors ; squamous cell carcinoma ; Urinary bladder ; Urinary Bladder - chemistry ; Urinary Bladder - pathology ; Urinary Bladder - virology ; Urinary Bladder Neoplasms - chemistry ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - virology ; Urological surgery ; urothelial carcinoma</subject><ispartof>Modern pathology, 2012-11, Vol.25 (11), p.1526-1533</ispartof><rights>United States and Canadian Academy of Pathology, Inc. 2012</rights><rights>Copyright Nature Publishing Group Nov 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-913c49a503bbd8b79975aa5f8011d0ddb437d7a9b46626969f4e6b0eb2c25d9a3</citedby><cites>FETCH-LOGICAL-c452t-913c49a503bbd8b79975aa5f8011d0ddb437d7a9b46626969f4e6b0eb2c25d9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1127762636?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22684221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexander, Riley E</creatorcontrib><creatorcontrib>Hu, Yingchuan</creatorcontrib><creatorcontrib>Kum, Jennifer B</creatorcontrib><creatorcontrib>Montironi, Rodolfo</creatorcontrib><creatorcontrib>Lopez-Beltran, Antonio</creatorcontrib><creatorcontrib>MacLennan, Gregory T</creatorcontrib><creatorcontrib>Idrees, Muhammad T</creatorcontrib><creatorcontrib>Emerson, Robert E</creatorcontrib><creatorcontrib>Ulbright, Thomas M</creatorcontrib><creatorcontrib>Grignon, David G</creatorcontrib><creatorcontrib>Eble, John N</creatorcontrib><creatorcontrib>Cheng, Liang</creatorcontrib><title>p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a well-established association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cell carcinoma of the urinary bladder is uncertain. The purposes of this study were to investigate the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy. In all, 42 cases of squamous cell carcinoma of the urinary bladder and 27 cases of urothelial carcinoma with squamous differentiation were investigated. HPV infection was analyzed by both
in situ
hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms.</description><subject>631/208/199</subject><subject>692/699/255/2514</subject><subject>692/699/67/589/1336</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bladder cancer</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Cell Differentiation</subject><subject>Cervix</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - analysis</subject><subject>Data processing</subject><subject>Differentiation</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>Etiology</subject><subject>Female</subject><subject>Head</subject><subject>Histology</subject><subject>Human papillomavirus</subject><subject>Human Papillomavirus DNA Tests</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Infection</subject><subject>Infections</subject><subject>Keratin</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Neck</subject><subject>original-article</subject><subject>p16 protein</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Papillomavirus Infections - virology</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Predictive Value of Tests</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>squamous cell carcinoma</subject><subject>Urinary bladder</subject><subject>Urinary Bladder - chemistry</subject><subject>Urinary Bladder - pathology</subject><subject>Urinary Bladder - virology</subject><subject>Urinary Bladder Neoplasms - chemistry</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - virology</subject><subject>Urological surgery</subject><subject>urothelial carcinoma</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9rHSEUxaU0NC9pv0AXReimm0n0Ouq4LKH_INBNsh6uo6_PMKMTnWnTb1-Hl4ZSKF0J9_7O8egh5DVnF5yJ7nJKbsblkMYLYBy22TOy41KwhkEnn5Md64xohJFwSs5KuWOMt7KDF-QUQHUtAN8RP3NF_cOcfSkhRRoKjWmhWEoaAi7e0R9hOdDDOmGkM85hHNOE30NeCw2RrjlEzD-pHdE5n2m5X3FKdTf4caQD5iHEyr8kJ3sci3_1eJ6T248fbq4-N9dfP325en_dDK2EpTFcDK1ByYS1rrPaGC0R5b5jnDvmnG2FdhqNbZUCZZTZt15Z5i0MIJ1BcU7eHX3nnO5XX5Z-CmWLgtHXVD0HqbWoUv1_lAujAGQrK_r2L_QurTnWh1QKtK5ZhKoUHKkhp1Ky3_dzDlP9nJ6zfuurf-qr3_raZlX05tF6tZN3T5LfBVVAHIFSV_Gbz3_c_W_bX4ALpR8</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Alexander, Riley E</creator><creator>Hu, Yingchuan</creator><creator>Kum, Jennifer B</creator><creator>Montironi, Rodolfo</creator><creator>Lopez-Beltran, Antonio</creator><creator>MacLennan, Gregory T</creator><creator>Idrees, Muhammad T</creator><creator>Emerson, Robert E</creator><creator>Ulbright, Thomas M</creator><creator>Grignon, David G</creator><creator>Eble, John N</creator><creator>Cheng, Liang</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20121101</creationdate><title>p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma</title><author>Alexander, Riley E ; Hu, Yingchuan ; Kum, Jennifer B ; Montironi, Rodolfo ; Lopez-Beltran, Antonio ; MacLennan, Gregory T ; Idrees, Muhammad T ; Emerson, Robert E ; Ulbright, Thomas M ; Grignon, David G ; Eble, John N ; Cheng, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-913c49a503bbd8b79975aa5f8011d0ddb437d7a9b46626969f4e6b0eb2c25d9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/208/199</topic><topic>692/699/255/2514</topic><topic>692/699/67/589/1336</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bladder cancer</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Cell Differentiation</topic><topic>Cervix</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - analysis</topic><topic>Data processing</topic><topic>Differentiation</topic><topic>DNA</topic><topic>DNA, Viral - analysis</topic><topic>Etiology</topic><topic>Female</topic><topic>Head</topic><topic>Histology</topic><topic>Human papillomavirus</topic><topic>Human Papillomavirus DNA Tests</topic><topic>Humans</topic><topic>Hybridization</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Infection</topic><topic>Infections</topic><topic>Keratin</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Neck</topic><topic>original-article</topic><topic>p16 protein</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Papillomavirus Infections - virology</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Predictive Value of Tests</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>squamous cell carcinoma</topic><topic>Urinary bladder</topic><topic>Urinary Bladder - chemistry</topic><topic>Urinary Bladder - pathology</topic><topic>Urinary Bladder - virology</topic><topic>Urinary Bladder Neoplasms - chemistry</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - virology</topic><topic>Urological surgery</topic><topic>urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexander, Riley E</creatorcontrib><creatorcontrib>Hu, Yingchuan</creatorcontrib><creatorcontrib>Kum, Jennifer B</creatorcontrib><creatorcontrib>Montironi, Rodolfo</creatorcontrib><creatorcontrib>Lopez-Beltran, Antonio</creatorcontrib><creatorcontrib>MacLennan, Gregory T</creatorcontrib><creatorcontrib>Idrees, Muhammad T</creatorcontrib><creatorcontrib>Emerson, Robert E</creatorcontrib><creatorcontrib>Ulbright, Thomas M</creatorcontrib><creatorcontrib>Grignon, David G</creatorcontrib><creatorcontrib>Eble, John N</creatorcontrib><creatorcontrib>Cheng, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexander, Riley E</au><au>Hu, Yingchuan</au><au>Kum, Jennifer B</au><au>Montironi, Rodolfo</au><au>Lopez-Beltran, Antonio</au><au>MacLennan, Gregory T</au><au>Idrees, Muhammad T</au><au>Emerson, Robert E</au><au>Ulbright, Thomas M</au><au>Grignon, David G</au><au>Eble, John N</au><au>Cheng, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>25</volume><issue>11</issue><spage>1526</spage><epage>1533</epage><pages>1526-1533</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>Squamous cell carcinoma of the urinary bladder is unusual and of unknown etiology. There is a well-established association between human papillomavirus (HPV) infection and the development of cervical and head/neck squamous cell carcinomas. However, the role of HPV in the pathogenesis of squamous cell carcinoma of the urinary bladder is uncertain. The purposes of this study were to investigate the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy. In all, 42 cases of squamous cell carcinoma of the urinary bladder and 27 cases of urothelial carcinoma with squamous differentiation were investigated. HPV infection was analyzed by both
in situ
hybridization at the DNA level and immunohistochemistry at the protein level. p16 protein expression was analyzed by immunohistochemistry. HPV DNA and protein were not detected in 42 cases of squamous cell carcinoma (0%, 0/42) or 27 cases of urothelial carcinoma with squamous differentiation (0%, 0/15). p16 expression was detected in 13 cases (31%, 13/42) of squamous cell carcinoma and 9 cases (33%, 9/27) of urothelial carcinoma with squamous differentiation. There was no correlation between p16 expression and the presence of HPV infection in squamous cell carcinoma of the bladder or urothelial carcinoma with squamous differentiation. Our data suggest that HPV does not play a role in the development of squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation. p16 expression should not be used as a surrogate marker for evidence of HVP infection in either squamous cell carcinoma of the urinary bladder or urothelial carcinoma with squamous differentiation as neither HVP DNA nor protein is detectable in these neoplasms.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>22684221</pmid><doi>10.1038/modpathol.2012.103</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-3952 |
| ispartof | Modern pathology, 2012-11, Vol.25 (11), p.1526-1533 |
| issn | 0893-3952 1530-0285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1257732697 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | 631/208/199 692/699/255/2514 692/699/67/589/1336 Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Bladder cancer Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cell Differentiation Cervix Cyclin-Dependent Kinase Inhibitor p16 - analysis Data processing Differentiation DNA DNA, Viral - analysis Etiology Female Head Histology Human papillomavirus Human Papillomavirus DNA Tests Humans Hybridization Immunohistochemistry In Situ Hybridization Infection Infections Keratin Laboratory Medicine Male Malignancy Medicine Medicine & Public Health Middle Aged Monoclonal antibodies Neck original-article p16 protein Papillomaviridae - genetics Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Papillomavirus Infections - virology Pathogenesis Pathology Predictive Value of Tests Proteins Risk Factors squamous cell carcinoma Urinary bladder Urinary Bladder - chemistry Urinary Bladder - pathology Urinary Bladder - virology Urinary Bladder Neoplasms - chemistry Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - virology Urological surgery urothelial carcinoma |
| title | p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T11%3A23%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=p16%20expression%20is%20not%20associated%20with%20human%20papillomavirus%20in%20urinary%20bladder%20squamous%20cell%20carcinoma&rft.jtitle=Modern%20pathology&rft.au=Alexander,%20Riley%20E&rft.date=2012-11-01&rft.volume=25&rft.issue=11&rft.spage=1526&rft.epage=1533&rft.pages=1526-1533&rft.issn=0893-3952&rft.eissn=1530-0285&rft.coden=MODPEO&rft_id=info:doi/10.1038/modpathol.2012.103&rft_dat=%3Cproquest_cross%3E2806976151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1127762636&rft_id=info:pmid/22684221&rfr_iscdi=true |