1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option
Background Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions. Objective We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Academy of Dermatology 2013-01, Vol.68 (1), p.98-102 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 102 |
|---|---|
| container_issue | 1 |
| container_start_page | 98 |
| container_title | Journal of the American Academy of Dermatology |
| container_volume | 68 |
| creator | Weiss, Elliot T., MD Brauer, Jeremy A., MD Anolik, Robert, MD Reddy, Kavitha K., MD Karen, Julie K., MD Hale, Elizabeth K., MD Brightman, Lori A., MD Bernstein, Leonard, MD Geronemus, Roy G., MD |
| description | Background Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions. Objective We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK. Methods This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser. Results At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage. Limitations This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing. Conclusion The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option. |
| doi_str_mv | 10.1016/j.jaad.2012.05.033 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1240907800</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0190962212006354</els_id><sourcerecordid>1240907800</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-2f65b061b0bdafb088a724964f44818e22ca45387029466db7c193e0b44e6da33</originalsourceid><addsrcrecordid>eNp9UU1v1TAQtBCIPgp_gAPKkUvC-iN2jBBSVVGoVKkH4IrlOBtwmhc_7KRV_z22XuHQAyevvDOj2RlCXlNoKFD5bmoma4eGAWUNtA1w_oTsKGhVS9Wpp2QHVEOtJWMn5EVKEwBowdVzcsI4CEop25EfVDNVL_vqIlq3-rDYuYqYtjha55efVRirMuXfsl68q24w2jUkTO-rs-oQw96nAlzwrlp_5d0BtzXDwqGovSTPRjsnfPXwnpLvF5--nX-pr64_X56fXdUu-1hrNsq2B0l76Ac79tB1VjGhpRiF6GiHjDkrWt4pYFpIOfTKUc0ReiFQDpbzU_L2qJsN_d4wrSbbcjjPdsGwJUOZAA2qA8hQdoS6GFKKOJpD9Hsb7w0FU3I1kym5mpKrgdbkXDPpzYP-1u9x-Ef5G2QGfDgCMF956zGa5DwuDgcf0a1mCP7_-h8f0d1c0rbzDd5jmsIWczP5DpMyx3wtzZZiKQOQvBX8D7konNs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1240907800</pqid></control><display><type>article</type><title>1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Weiss, Elliot T., MD ; Brauer, Jeremy A., MD ; Anolik, Robert, MD ; Reddy, Kavitha K., MD ; Karen, Julie K., MD ; Hale, Elizabeth K., MD ; Brightman, Lori A., MD ; Bernstein, Leonard, MD ; Geronemus, Roy G., MD</creator><creatorcontrib>Weiss, Elliot T., MD ; Brauer, Jeremy A., MD ; Anolik, Robert, MD ; Reddy, Kavitha K., MD ; Karen, Julie K., MD ; Hale, Elizabeth K., MD ; Brightman, Lori A., MD ; Bernstein, Leonard, MD ; Geronemus, Roy G., MD</creatorcontrib><description>Background Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions. Objective We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK. Methods This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser. Results At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage. Limitations This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing. Conclusion The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2012.05.033</identifier><identifier>PMID: 23041112</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>actinic keratosis ; Dermatology ; Edema - etiology ; Erythema - etiology ; Facial Dermatoses - surgery ; Female ; Humans ; Keratosis, Actinic - surgery ; laser ; Laser Therapy - adverse effects ; Laser Therapy - methods ; Male ; Middle Aged ; nonablative resurfacing ; photodamage ; rejuvenation ; Thulium ; Treatment Outcome</subject><ispartof>Journal of the American Academy of Dermatology, 2013-01, Vol.68 (1), p.98-102</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2012 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-2f65b061b0bdafb088a724964f44818e22ca45387029466db7c193e0b44e6da33</citedby><cites>FETCH-LOGICAL-c411t-2f65b061b0bdafb088a724964f44818e22ca45387029466db7c193e0b44e6da33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2012.05.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23041112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiss, Elliot T., MD</creatorcontrib><creatorcontrib>Brauer, Jeremy A., MD</creatorcontrib><creatorcontrib>Anolik, Robert, MD</creatorcontrib><creatorcontrib>Reddy, Kavitha K., MD</creatorcontrib><creatorcontrib>Karen, Julie K., MD</creatorcontrib><creatorcontrib>Hale, Elizabeth K., MD</creatorcontrib><creatorcontrib>Brightman, Lori A., MD</creatorcontrib><creatorcontrib>Bernstein, Leonard, MD</creatorcontrib><creatorcontrib>Geronemus, Roy G., MD</creatorcontrib><title>1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions. Objective We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK. Methods This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser. Results At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage. Limitations This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing. Conclusion The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option.</description><subject>actinic keratosis</subject><subject>Dermatology</subject><subject>Edema - etiology</subject><subject>Erythema - etiology</subject><subject>Facial Dermatoses - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Keratosis, Actinic - surgery</subject><subject>laser</subject><subject>Laser Therapy - adverse effects</subject><subject>Laser Therapy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nonablative resurfacing</subject><subject>photodamage</subject><subject>rejuvenation</subject><subject>Thulium</subject><subject>Treatment Outcome</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1TAQtBCIPgp_gAPKkUvC-iN2jBBSVVGoVKkH4IrlOBtwmhc_7KRV_z22XuHQAyevvDOj2RlCXlNoKFD5bmoma4eGAWUNtA1w_oTsKGhVS9Wpp2QHVEOtJWMn5EVKEwBowdVzcsI4CEop25EfVDNVL_vqIlq3-rDYuYqYtjha55efVRirMuXfsl68q24w2jUkTO-rs-oQw96nAlzwrlp_5d0BtzXDwqGovSTPRjsnfPXwnpLvF5--nX-pr64_X56fXdUu-1hrNsq2B0l76Ac79tB1VjGhpRiF6GiHjDkrWt4pYFpIOfTKUc0ReiFQDpbzU_L2qJsN_d4wrSbbcjjPdsGwJUOZAA2qA8hQdoS6GFKKOJpD9Hsb7w0FU3I1kym5mpKrgdbkXDPpzYP-1u9x-Ef5G2QGfDgCMF956zGa5DwuDgcf0a1mCP7_-h8f0d1c0rbzDd5jmsIWczP5DpMyx3wtzZZiKQOQvBX8D7konNs</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Weiss, Elliot T., MD</creator><creator>Brauer, Jeremy A., MD</creator><creator>Anolik, Robert, MD</creator><creator>Reddy, Kavitha K., MD</creator><creator>Karen, Julie K., MD</creator><creator>Hale, Elizabeth K., MD</creator><creator>Brightman, Lori A., MD</creator><creator>Bernstein, Leonard, MD</creator><creator>Geronemus, Roy G., MD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option</title><author>Weiss, Elliot T., MD ; Brauer, Jeremy A., MD ; Anolik, Robert, MD ; Reddy, Kavitha K., MD ; Karen, Julie K., MD ; Hale, Elizabeth K., MD ; Brightman, Lori A., MD ; Bernstein, Leonard, MD ; Geronemus, Roy G., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-2f65b061b0bdafb088a724964f44818e22ca45387029466db7c193e0b44e6da33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>actinic keratosis</topic><topic>Dermatology</topic><topic>Edema - etiology</topic><topic>Erythema - etiology</topic><topic>Facial Dermatoses - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Keratosis, Actinic - surgery</topic><topic>laser</topic><topic>Laser Therapy - adverse effects</topic><topic>Laser Therapy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nonablative resurfacing</topic><topic>photodamage</topic><topic>rejuvenation</topic><topic>Thulium</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Elliot T., MD</creatorcontrib><creatorcontrib>Brauer, Jeremy A., MD</creatorcontrib><creatorcontrib>Anolik, Robert, MD</creatorcontrib><creatorcontrib>Reddy, Kavitha K., MD</creatorcontrib><creatorcontrib>Karen, Julie K., MD</creatorcontrib><creatorcontrib>Hale, Elizabeth K., MD</creatorcontrib><creatorcontrib>Brightman, Lori A., MD</creatorcontrib><creatorcontrib>Bernstein, Leonard, MD</creatorcontrib><creatorcontrib>Geronemus, Roy G., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Elliot T., MD</au><au>Brauer, Jeremy A., MD</au><au>Anolik, Robert, MD</au><au>Reddy, Kavitha K., MD</au><au>Karen, Julie K., MD</au><au>Hale, Elizabeth K., MD</au><au>Brightman, Lori A., MD</au><au>Bernstein, Leonard, MD</au><au>Geronemus, Roy G., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>68</volume><issue>1</issue><spage>98</spage><epage>102</epage><pages>98-102</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Background Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions. Objective We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK. Methods This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser. Results At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage. Limitations This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing. Conclusion The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>23041112</pmid><doi>10.1016/j.jaad.2012.05.033</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 2013-01, Vol.68 (1), p.98-102 |
| issn | 0190-9622 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1240907800 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | actinic keratosis Dermatology Edema - etiology Erythema - etiology Facial Dermatoses - surgery Female Humans Keratosis, Actinic - surgery laser Laser Therapy - adverse effects Laser Therapy - methods Male Middle Aged nonablative resurfacing photodamage rejuvenation Thulium Treatment Outcome |
| title | 1927-nm Fractional resurfacing of facial actinic keratoses: A promising new therapeutic option |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T11%3A08%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=1927-nm%20Fractional%20resurfacing%20of%20facial%20actinic%20keratoses:%20A%20promising%20new%20therapeutic%20option&rft.jtitle=Journal%20of%20the%20American%20Academy%20of%20Dermatology&rft.au=Weiss,%20Elliot%20T.,%20MD&rft.date=2013-01-01&rft.volume=68&rft.issue=1&rft.spage=98&rft.epage=102&rft.pages=98-102&rft.issn=0190-9622&rft.eissn=1097-6787&rft_id=info:doi/10.1016/j.jaad.2012.05.033&rft_dat=%3Cproquest_cross%3E1240907800%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1240907800&rft_id=info:pmid/23041112&rft_els_id=S0190962212006354&rfr_iscdi=true |