Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells

Based on the previous result, several naringenin derivatives modified at position 7 with bulky substituents were designed and synthesized, and their inhibitory effects on HCT116 human colon cancer cells were tested using a clonogenic assay. The half maximal inhibitory concentrations (IC50) of five n...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-01, Vol.23 (1), p.232-238
Hauptverfasser:	Yoon, Hyuk, Kim, Tae Woo, Shin, Soon Young, Park, Mi Joo, Yong, Yeonjoong, Kim, Dong Woon, Islam, Tasneem, Lee, Young Han, Jung, Kang-Yeoun, Lim, Yoongho
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity antioxidant activity Binding Sites Cell Survival - drug effects Colon cancer Colonic Neoplasms - metabolism Colonic Neoplasms - pathology colorectal neoplasms cyclin-dependent kinase Cyclin-Dependent Kinase 2 - chemistry Cyclin-Dependent Kinase 2 - metabolism Drug Design Flavanone Flavanones - chemical synthesis Flavanones - chemistry Flavanones - toxicity HCT116 Cells Humans In silico docking inhibitory concentration 50 Molecular Docking Simulation Naringenin Protein Binding Protein Structure, Tertiary
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