Vitiligo road map
Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a “vitiligo road map,” consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogene...
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| Veröffentlicht in: | Dermatologic therapy 2012-11, Vol.25 (S1), p.S44-S56 |
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| container_issue | S1 |
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| container_title | Dermatologic therapy |
| container_volume | 25 |
| creator | Lee, Brian W. Schwartz, Robert A. Hercogová, Jana Valle, Yan Lotti, Torello M. |
| description | Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a “vitiligo road map,” consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation. |
| doi_str_mv | 10.1111/dth.12006 |
| format | Article |
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It has a complex, multifaceted etiology. We constructed a “vitiligo road map,” consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation.</description><identifier>ISSN: 1396-0296</identifier><identifier>EISSN: 1529-8019</identifier><identifier>DOI: 10.1111/dth.12006</identifier><identifier>PMID: 23237038</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; biomarkers ; Biomarkers - metabolism ; Dermatologic Agents - therapeutic use ; Dogs ; Humans ; Immunosuppressive Agents - therapeutic use ; Laser Therapy - methods ; melanocyte ; Melanocytes - immunology ; melanogenesis ; Photochemotherapy - methods ; Phototherapy - methods ; pigmentation ; Pigmentation - physiology ; Skin Transplantation - methods ; Treatment Outcome ; vitiligo ; Vitiligo - immunology ; Vitiligo - physiopathology ; Vitiligo - therapy</subject><ispartof>Dermatologic therapy, 2012-11, Vol.25 (S1), p.S44-S56</ispartof><rights>2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3646-f5ed6cec0f815c991789186c76178e309f2dd0eb4b1e12719182548de6eefc2e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdth.12006$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdth.12006$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23237038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Brian W.</creatorcontrib><creatorcontrib>Schwartz, Robert A.</creatorcontrib><creatorcontrib>Hercogová, Jana</creatorcontrib><creatorcontrib>Valle, Yan</creatorcontrib><creatorcontrib>Lotti, Torello M.</creatorcontrib><title>Vitiligo road map</title><title>Dermatologic therapy</title><addtitle>Dermatol Ther</addtitle><description>Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a “vitiligo road map,” consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation.</description><subject>Animals</subject><subject>biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dogs</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Laser Therapy - methods</subject><subject>melanocyte</subject><subject>Melanocytes - immunology</subject><subject>melanogenesis</subject><subject>Photochemotherapy - methods</subject><subject>Phototherapy - methods</subject><subject>pigmentation</subject><subject>Pigmentation - physiology</subject><subject>Skin Transplantation - methods</subject><subject>Treatment Outcome</subject><subject>vitiligo</subject><subject>Vitiligo - immunology</subject><subject>Vitiligo - physiopathology</subject><subject>Vitiligo - therapy</subject><issn>1396-0296</issn><issn>1529-8019</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFPwkAQhTdGI4ge-AOGo5fCzG673T0aVDCgJgY18bIp7VRXWwvdEuXfuwIyl3nJ-94k8xjrIvTRzyBr3vvIAeQBa2PEdaAA9aHXQssAuJYtduLcBwByLfCYtbjgIgah2qz7bBtb2LeqV1dJ1iuTxSk7ypPC0dlud9jTzfVsOA6mD6Pb4eU0SIUMZZBHlMmUUsgVRqnWGCuNSqax9IoE6JxnGdA8nCMhj9GbPApVRpIoTzmJDrvY3l3U1XJFrjGldSkVRfJF1coZ5CEorYHHHj3foat5SZlZ1LZM6rX5f8MDgy3wbQta730E89eP8f2YTT_majbeCJ8ItgnrGvrZJ5L608hYxJF5uR-ZyWM0gbvXsdHiF6Q4Y3w</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Lee, Brian W.</creator><creator>Schwartz, Robert A.</creator><creator>Hercogová, Jana</creator><creator>Valle, Yan</creator><creator>Lotti, Torello M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Vitiligo road map</title><author>Lee, Brian W. ; Schwartz, Robert A. ; Hercogová, Jana ; Valle, Yan ; Lotti, Torello M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3646-f5ed6cec0f815c991789186c76178e309f2dd0eb4b1e12719182548de6eefc2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dogs</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Laser Therapy - methods</topic><topic>melanocyte</topic><topic>Melanocytes - immunology</topic><topic>melanogenesis</topic><topic>Photochemotherapy - methods</topic><topic>Phototherapy - methods</topic><topic>pigmentation</topic><topic>Pigmentation - physiology</topic><topic>Skin Transplantation - methods</topic><topic>Treatment Outcome</topic><topic>vitiligo</topic><topic>Vitiligo - immunology</topic><topic>Vitiligo - physiopathology</topic><topic>Vitiligo - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Brian W.</creatorcontrib><creatorcontrib>Schwartz, Robert A.</creatorcontrib><creatorcontrib>Hercogová, Jana</creatorcontrib><creatorcontrib>Valle, Yan</creatorcontrib><creatorcontrib>Lotti, Torello M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Brian W.</au><au>Schwartz, Robert A.</au><au>Hercogová, Jana</au><au>Valle, Yan</au><au>Lotti, Torello M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitiligo road map</atitle><jtitle>Dermatologic therapy</jtitle><addtitle>Dermatol Ther</addtitle><date>2012-11</date><risdate>2012</risdate><volume>25</volume><issue>S1</issue><spage>S44</spage><epage>S56</epage><pages>S44-S56</pages><issn>1396-0296</issn><eissn>1529-8019</eissn><abstract>Vitiligo is a depigmenting disorder stemming from melanocyte loss or dysfunction. It has a complex, multifaceted etiology. We constructed a “vitiligo road map,” consisting of basic science, clinical, and treatment components, in order to better portray our current understanding of vitiligo pathogenesis and reflect upon novel biomarkers and therapeutic targets for future research. The melanocyte map elaborates on the molecular processes and intracellular signaling pathways initiated by various external autocrine/paracrine factors in representing normal melanocyte homeostatic functions modulating its viability, proliferation, differentiation, dendricity, migration, and melanogenic processes. This vitiligo map identifies known inducers/triggers of vitiligo onset and progression that cultivate a microenvironment for melanocyte disappearance, real or functional. This map describes the molecular mechanisms of currently utilized clinical and experimental treatments of vitiligo that facilitate repigmentation.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23237038</pmid><doi>10.1111/dth.12006</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Dermatologic therapy, 2012-11, Vol.25 (S1), p.S44-S56 |
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| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Animals biomarkers Biomarkers - metabolism Dermatologic Agents - therapeutic use Dogs Humans Immunosuppressive Agents - therapeutic use Laser Therapy - methods melanocyte Melanocytes - immunology melanogenesis Photochemotherapy - methods Phototherapy - methods pigmentation Pigmentation - physiology Skin Transplantation - methods Treatment Outcome vitiligo Vitiligo - immunology Vitiligo - physiopathology Vitiligo - therapy |
| title | Vitiligo road map |
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