Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells

Trans-3,4′,5-trihydroxystilbene (resveratrol) is a grape polyphenol present in various plants, food products, red wine and grapes. Resveratrol has anti-inflammatory, anticarcinogenic, anti-oxidant and anti-aging properties. Matrix metalloproteinases (MMPs) are key enzymes involved in the degradation...

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Veröffentlicht in:	Oncology reports 2013-02, Vol.29 (2), p.826-834
Hauptverfasser:	GWEON, EUN JEONG, KIM, SONG JA
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Breast cancer Cell adhesion & migration Cell cycle Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Fibrosarcoma Fibrosarcoma - metabolism Gastric cancer Growth factors HT1080 Humans Kinases MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 9 - metabolism matrix metalloproteinase-9 Medical prognosis Metastasis migration p38 kinase p38 Mitogen-Activated Protein Kinases - metabolism phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Prevention Proto-Oncogene Proteins c-akt - metabolism resveratrol Rodents Signal transduction Stilbenes - pharmacology Studies
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