Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features
The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA...
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| Veröffentlicht in: | Oncology reports 2013-02, Vol.29 (2), p.704-712 |
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| creator | SUN, YIFENG SU, BO ZHANG, PENG XIE, HUIKANG ZHENG, HUI XU, YONGJIE DU, QIAOLING ZENG, HUAN ZHOU, XIAO CHEN, CHANG GAO, WEN |
| description | The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, miR-643 and miR-3940-5p were detected by real-time PCR; p53, EGFR, Kras and Ki-67 expression in tumor tissues was determined by immunohistochemistry. p53 mRNA expression levels in NSCLC were examined by SYBR-Green real-time PCR. The relationship between the four miRNAs and clinicopathologic features of 90 cases was analyzed. The expression of miR-150 and miR-3940-5p was significantly downregulated in tumor tissues and embryonic lung tissues compared to normal lung tissues. The expression of miR-150 and miR-3940-5p in tumor tissues was also lower than that in the matched tumor-adjacent tissues. miR-150 was downregulated preferentially in subgroups of patients with a tumor diameter more than or equal to 3 cm, in smokers and in stage III and IV tumors. Specifically, miR-150 and miR-3940-5p expression was decreased in nuclear cell proliferation antigen Ki-67-positive NSCLC cases. miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA. Reduced miR-150 and miR-3940-5p expression in tumor tissues and embryonic lung tissues suggests that these miRs may be involved in the tumorigenesis or de-differentiation of NSCLC. Due to this associaton with the Ki-67 proliferation index in NSCLC, downregulation of miR-150 and miR-3940-5p may contribute to tumor growth and proliferation. miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway. |
| doi_str_mv | 10.3892/or.2012.2152 |
| format | Article |
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Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, miR-643 and miR-3940-5p were detected by real-time PCR; p53, EGFR, Kras and Ki-67 expression in tumor tissues was determined by immunohistochemistry. p53 mRNA expression levels in NSCLC were examined by SYBR-Green real-time PCR. The relationship between the four miRNAs and clinicopathologic features of 90 cases was analyzed. The expression of miR-150 and miR-3940-5p was significantly downregulated in tumor tissues and embryonic lung tissues compared to normal lung tissues. The expression of miR-150 and miR-3940-5p in tumor tissues was also lower than that in the matched tumor-adjacent tissues. miR-150 was downregulated preferentially in subgroups of patients with a tumor diameter more than or equal to 3 cm, in smokers and in stage III and IV tumors. Specifically, miR-150 and miR-3940-5p expression was decreased in nuclear cell proliferation antigen Ki-67-positive NSCLC cases. miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA. Reduced miR-150 and miR-3940-5p expression in tumor tissues and embryonic lung tissues suggests that these miRs may be involved in the tumorigenesis or de-differentiation of NSCLC. Due to this associaton with the Ki-67 proliferation index in NSCLC, downregulation of miR-150 and miR-3940-5p may contribute to tumor growth and proliferation. miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2012.2152</identifier><identifier>PMID: 23228962</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Aged ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - secondary ; Chi-Square Distribution ; clinicopathology ; Cloning ; Down-Regulation ; Female ; Genes ; Humans ; Independent sample ; Ki-67 Antigen - metabolism ; Localization ; Lung - embryology ; Lung - metabolism ; Lung cancer ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lymphatic Metastasis ; Male ; Medical prognosis ; Metastasis ; microRNAs ; MicroRNAs - metabolism ; Middle Aged ; non-small cell lung carcinoma ; Protein expression ; Proteins ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins p21(ras) ; quantitative RT-PCR ; ras Proteins - metabolism ; Receptor, Epidermal Growth Factor - metabolism ; RNA, Messenger - metabolism ; Statistical analysis ; Statistics, Nonparametric ; Studies ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>Oncology reports, 2013-02, Vol.29 (2), p.704-712</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-35ba2f26788ed1d7a9ded219bf41f1a102acac6981bb92d4cfe77254fe30a84b3</citedby><cites>FETCH-LOGICAL-c388t-35ba2f26788ed1d7a9ded219bf41f1a102acac6981bb92d4cfe77254fe30a84b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23228962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUN, YIFENG</creatorcontrib><creatorcontrib>SU, BO</creatorcontrib><creatorcontrib>ZHANG, PENG</creatorcontrib><creatorcontrib>XIE, HUIKANG</creatorcontrib><creatorcontrib>ZHENG, HUI</creatorcontrib><creatorcontrib>XU, YONGJIE</creatorcontrib><creatorcontrib>DU, QIAOLING</creatorcontrib><creatorcontrib>ZENG, HUAN</creatorcontrib><creatorcontrib>ZHOU, XIAO</creatorcontrib><creatorcontrib>CHEN, CHANG</creatorcontrib><creatorcontrib>GAO, WEN</creatorcontrib><title>Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, miR-643 and miR-3940-5p were detected by real-time PCR; p53, EGFR, Kras and Ki-67 expression in tumor tissues was determined by immunohistochemistry. p53 mRNA expression levels in NSCLC were examined by SYBR-Green real-time PCR. The relationship between the four miRNAs and clinicopathologic features of 90 cases was analyzed. The expression of miR-150 and miR-3940-5p was significantly downregulated in tumor tissues and embryonic lung tissues compared to normal lung tissues. The expression of miR-150 and miR-3940-5p in tumor tissues was also lower than that in the matched tumor-adjacent tissues. miR-150 was downregulated preferentially in subgroups of patients with a tumor diameter more than or equal to 3 cm, in smokers and in stage III and IV tumors. Specifically, miR-150 and miR-3940-5p expression was decreased in nuclear cell proliferation antigen Ki-67-positive NSCLC cases. miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA. Reduced miR-150 and miR-3940-5p expression in tumor tissues and embryonic lung tissues suggests that these miRs may be involved in the tumorigenesis or de-differentiation of NSCLC. Due to this associaton with the Ki-67 proliferation index in NSCLC, downregulation of miR-150 and miR-3940-5p may contribute to tumor growth and proliferation. miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway.</description><subject>Aged</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - secondary</subject><subject>Chi-Square Distribution</subject><subject>clinicopathology</subject><subject>Cloning</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Genes</subject><subject>Humans</subject><subject>Independent sample</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Localization</subject><subject>Lung - embryology</subject><subject>Lung - metabolism</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>microRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>non-small cell lung carcinoma</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>quantitative RT-PCR</subject><subject>ras Proteins - metabolism</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Statistical analysis</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkctrFTEUxoNYbK3uXEtAEBfmmpxkZpKllPqAQkEU3IVMHm3KTDImM6hb__Lm9tYuujnnLH7n8Z0PoVeM7rhU8CGXHVAGO2AdPEEnbFCMgODsaaspMMJ59_MYPa_1hlIYaK-eoWPgAFL1cIL-nf9Ziq815oRzwHP8RlhHsUnuruZKUNItOFZcvNusdzgmnHIidTbThK1vYdrSFbam2JjybO56bS7FT2b1Ff-O6zW2U0zR5sWs13nKV9GaCQdv1q3tfoGOgpmqf3mfT9GPT-ffz76Qi8vPX88-XhDLpVwJ70YDAfpBSu-YG4xy3gFTYxAsMNO0GmtsryQbRwVO2OCHAToRPKdGipGfoneHuUvJvzZfVz3Huhdgks9b1QxE-xeVfd_QN4_Qm7yV1K7TTHHoeyWEaNT7A2VLrrX4oJcSZ1P-akb13hudi957o_feNPz1_dBtnL17gP-b0YC3B6Au7YfR5frA5EJAEQqEDlTwW5wEllA</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>SUN, YIFENG</creator><creator>SU, BO</creator><creator>ZHANG, PENG</creator><creator>XIE, HUIKANG</creator><creator>ZHENG, HUI</creator><creator>XU, YONGJIE</creator><creator>DU, QIAOLING</creator><creator>ZENG, HUAN</creator><creator>ZHOU, XIAO</creator><creator>CHEN, CHANG</creator><creator>GAO, WEN</creator><general>D.A. 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metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - secondary</topic><topic>Chi-Square Distribution</topic><topic>clinicopathology</topic><topic>Cloning</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Genes</topic><topic>Humans</topic><topic>Independent sample</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Localization</topic><topic>Lung - embryology</topic><topic>Lung - metabolism</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>microRNAs</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>non-small cell lung carcinoma</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins p21(ras)</topic><topic>quantitative RT-PCR</topic><topic>ras Proteins - metabolism</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Statistical analysis</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUN, YIFENG</creatorcontrib><creatorcontrib>SU, BO</creatorcontrib><creatorcontrib>ZHANG, PENG</creatorcontrib><creatorcontrib>XIE, HUIKANG</creatorcontrib><creatorcontrib>ZHENG, HUI</creatorcontrib><creatorcontrib>XU, YONGJIE</creatorcontrib><creatorcontrib>DU, QIAOLING</creatorcontrib><creatorcontrib>ZENG, HUAN</creatorcontrib><creatorcontrib>ZHOU, XIAO</creatorcontrib><creatorcontrib>CHEN, CHANG</creatorcontrib><creatorcontrib>GAO, WEN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUN, YIFENG</au><au>SU, BO</au><au>ZHANG, PENG</au><au>XIE, HUIKANG</au><au>ZHENG, HUI</au><au>XU, YONGJIE</au><au>DU, QIAOLING</au><au>ZENG, HUAN</au><au>ZHOU, XIAO</au><au>CHEN, CHANG</au><au>GAO, WEN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>29</volume><issue>2</issue><spage>704</spage><epage>712</epage><pages>704-712</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, miR-643 and miR-3940-5p were detected by real-time PCR; p53, EGFR, Kras and Ki-67 expression in tumor tissues was determined by immunohistochemistry. p53 mRNA expression levels in NSCLC were examined by SYBR-Green real-time PCR. The relationship between the four miRNAs and clinicopathologic features of 90 cases was analyzed. The expression of miR-150 and miR-3940-5p was significantly downregulated in tumor tissues and embryonic lung tissues compared to normal lung tissues. The expression of miR-150 and miR-3940-5p in tumor tissues was also lower than that in the matched tumor-adjacent tissues. miR-150 was downregulated preferentially in subgroups of patients with a tumor diameter more than or equal to 3 cm, in smokers and in stage III and IV tumors. Specifically, miR-150 and miR-3940-5p expression was decreased in nuclear cell proliferation antigen Ki-67-positive NSCLC cases. miR-150 and miR-3940-5p were found to be significantly downregulated in p53 IHC-positive NSCLC cases and were negatively correlated with p53 mRNA. Reduced miR-150 and miR-3940-5p expression in tumor tissues and embryonic lung tissues suggests that these miRs may be involved in the tumorigenesis or de-differentiation of NSCLC. Due to this associaton with the Ki-67 proliferation index in NSCLC, downregulation of miR-150 and miR-3940-5p may contribute to tumor growth and proliferation. miR-150 and miR-3940-5p may affect p53 expression through a direct or indirect pathway.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23228962</pmid><doi>10.3892/or.2012.2152</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - secondary Chi-Square Distribution clinicopathology Cloning Down-Regulation Female Genes Humans Independent sample Ki-67 Antigen - metabolism Localization Lung - embryology Lung - metabolism Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis Male Medical prognosis Metastasis microRNAs MicroRNAs - metabolism Middle Aged non-small cell lung carcinoma Protein expression Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) quantitative RT-PCR ras Proteins - metabolism Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - metabolism Statistical analysis Statistics, Nonparametric Studies Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors |
| title | Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features |
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