Single immunization with a suboptimal antigen dose encapsulated into polyanhydride microparticles promotes high titer and avid antibody responses

Microparticle adjuvants based on biodegradable polyanhydrides were used to provide controlled delivery of a model antigen, ovalbumin (Ova), to mice. Ova was encapsulated into two different polyanhydride microparticle formulations to evaluate the influence of polymer chemistry on the nature and magni...

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Veröffentlicht in:	Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2013-01, Vol.101B (1), p.91-98
Hauptverfasser:	Huntimer, Lucas, Wilson Welder, Jennifer H., Ross, Kathleen, Carrillo-Conde, Brenda, Pruisner, Lynn, Wang, Chong, Narasimhan, Balaji, Wannemuehler, Michael J., Ramer-Tait, Amanda E.
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant Animals Antibody Formation - immunology Antigens - administration & dosage Antigens - immunology avidity Biological and medical sciences Female General pharmacology Immunologic Memory Medical sciences Mice Mice, Inbred C3H microparticle Microscopy, Electron, Scanning Microspheres ovalbumin Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polyanhydride Polyanhydrides - administration & dosage
Online-Zugang:	Volltext
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