Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways

Abstract Background and purpose Although inhibition of epidermal growth factor receptor (EGFR) signaling during radiation led to improvement of tumor control and survival, novel strategies are needed to further improve the outcome of patients with locally advanced head and neck carcinoma. Because EG...

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Veröffentlicht in:	Radiotherapy and oncology 2012-11, Vol.105 (2), p.241-249
Hauptverfasser:	Raju, Uma, Riesterer, Oliver, Wang, Zhi-Qiang, Molkentine, David P, Molkentine, Jessica M, Johnson, Faye M, Glisson, Bonnie, Milas, Luka, Ang, K. Kian
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Apoptosis - radiation effects c-Src Carcinoma, Squamous Cell - radiotherapy Cell Cycle Cell Nucleus - metabolism Dasatinib DNA repair DNA Repair - drug effects EGFR ErbB Receptors - analysis ErbB Receptors - metabolism Focal Adhesion Protein-Tyrosine Kinases - metabolism Head and neck cancer Head and Neck Neoplasms - radiotherapy Hematology, Oncology and Palliative Medicine Humans Protein Kinase Inhibitors - pharmacology Pyrimidines - pharmacology Radiation sensitivity Radiation Tolerance - drug effects Squamous Cell Carcinoma of Head and Neck src-Family Kinases - analysis src-Family Kinases - metabolism Thiazoles - pharmacology
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