Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation
Summary The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our co...
Gespeichert in:
| Veröffentlicht in: | Transplant international 2013-01, Vol.26 (1), p.67-74 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 74 |
|---|---|
| container_issue | 1 |
| container_start_page | 67 |
| container_title | Transplant international |
| container_volume | 26 |
| creator | Sprinzl, Martin F. Weinmann, Arndt Lohse, Nikola Tönissen, Hanna Koch, Sandra Schattenberg, Jörn Hoppe‐Lotichius, Maria Zimmermann, Tim Galle, Peter R. Hansen, Torsten Otto, Gerd Schuchmann, Marcus |
| description | Summary
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.56–8.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.69–10.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.46–14.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid dosage after OLT (5.2 ± 2.4 mg/day vs. 7.1 ± 4.7 mg/day, P = 0.014), and was linked to NAFLD (P = 0.001) via obesity (OR = 4.67, CI = 1.55–14.1, P = 0.006) and dyslipidemia (OR = 4.23, CI = 1.35–13.3, P = 0.013) post‐OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT. |
| doi_str_mv | 10.1111/j.1432-2277.2012.01576.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1239054763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1239054763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3486-dd9909bb9440cc312b7c9bfd0157c32634f8952795791fa578ddaa6c0d068b23</originalsourceid><addsrcrecordid>eNpdkUtPAyEUhYnRaH38BUPixs2MvAaGhQvT-EpqTEz3hAEm0kyHOlBr_72M1S5kAzfn4-bcewCAGJU4n5tFiRklBSFClARhUiJcCV5-HYDJXjgEEyQpK1At2Ak4jXGBECJ1hY7BCaGYcC7YBLQvLukmdN7AuO3tEJYO6t5CnyLUMQbjdfKhhxuf3mGrU9rCzn-6AVofnY4ZblOuwpDeQwqr3GYnp0H3cdXpPv38PwdHre6iu_i9z8D84X4-fSpmr4_P07tZYSireWGtlEg2jWQMGZNNNsLIprXjeIYSTllby4oIWQmJW12J2lqtuUEW8boh9Axc79quhvCxdjGppY_GddmHC-uoMKESVUxwmtGrf-girIc-m1NYcC7RSGbq8pdaN0tn1WrwSz1s1d8CM3C7Aza-c9u9jpEag1ILNeahxjzUGJT6CUp9qfnb8_ii3w4ZhxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1766903905</pqid></control><display><type>article</type><title>Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Sprinzl, Martin F. ; Weinmann, Arndt ; Lohse, Nikola ; Tönissen, Hanna ; Koch, Sandra ; Schattenberg, Jörn ; Hoppe‐Lotichius, Maria ; Zimmermann, Tim ; Galle, Peter R. ; Hansen, Torsten ; Otto, Gerd ; Schuchmann, Marcus</creator><creatorcontrib>Sprinzl, Martin F. ; Weinmann, Arndt ; Lohse, Nikola ; Tönissen, Hanna ; Koch, Sandra ; Schattenberg, Jörn ; Hoppe‐Lotichius, Maria ; Zimmermann, Tim ; Galle, Peter R. ; Hansen, Torsten ; Otto, Gerd ; Schuchmann, Marcus</creatorcontrib><description>Summary
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.56–8.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.69–10.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.46–14.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid dosage after OLT (5.2 ± 2.4 mg/day vs. 7.1 ± 4.7 mg/day, P = 0.014), and was linked to NAFLD (P = 0.001) via obesity (OR = 4.67, CI = 1.55–14.1, P = 0.006) and dyslipidemia (OR = 4.23, CI = 1.35–13.3, P = 0.013) post‐OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2012.01576.x</identifier><identifier>PMID: 23126674</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; body mass index ; Confidence intervals ; Fatty Liver - etiology ; Fatty Liver - pathology ; Glycated Hemoglobin A - analysis ; glycosylated hemoglobin ; Humans ; Liver cirrhosis ; Liver diseases ; Liver Transplantation - adverse effects ; Metabolic syndrome ; Metabolic Syndrome - etiology ; Middle Aged ; Multivariate analysis ; obesity ; Retrospective Studies ; Risk Factors ; Transplants & implants</subject><ispartof>Transplant international, 2013-01, Vol.26 (1), p.67-74</ispartof><rights>2012 The Authors Transplant International © 2012 European Society for Organ Transplantation. Published by Blackwell Publishing Ltd</rights><rights>2012 The Authors Transplant International © 2012 European Society for Organ Transplantation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3486-dd9909bb9440cc312b7c9bfd0157c32634f8952795791fa578ddaa6c0d068b23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2012.01576.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2012.01576.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23126674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sprinzl, Martin F.</creatorcontrib><creatorcontrib>Weinmann, Arndt</creatorcontrib><creatorcontrib>Lohse, Nikola</creatorcontrib><creatorcontrib>Tönissen, Hanna</creatorcontrib><creatorcontrib>Koch, Sandra</creatorcontrib><creatorcontrib>Schattenberg, Jörn</creatorcontrib><creatorcontrib>Hoppe‐Lotichius, Maria</creatorcontrib><creatorcontrib>Zimmermann, Tim</creatorcontrib><creatorcontrib>Galle, Peter R.</creatorcontrib><creatorcontrib>Hansen, Torsten</creatorcontrib><creatorcontrib>Otto, Gerd</creatorcontrib><creatorcontrib>Schuchmann, Marcus</creatorcontrib><title>Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.56–8.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.69–10.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.46–14.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid dosage after OLT (5.2 ± 2.4 mg/day vs. 7.1 ± 4.7 mg/day, P = 0.014), and was linked to NAFLD (P = 0.001) via obesity (OR = 4.67, CI = 1.55–14.1, P = 0.006) and dyslipidemia (OR = 4.23, CI = 1.35–13.3, P = 0.013) post‐OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT.</description><subject>Adult</subject><subject>Aged</subject><subject>body mass index</subject><subject>Confidence intervals</subject><subject>Fatty Liver - etiology</subject><subject>Fatty Liver - pathology</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>glycosylated hemoglobin</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver Transplantation - adverse effects</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - etiology</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>obesity</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Transplants & implants</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtPAyEUhYnRaH38BUPixs2MvAaGhQvT-EpqTEz3hAEm0kyHOlBr_72M1S5kAzfn4-bcewCAGJU4n5tFiRklBSFClARhUiJcCV5-HYDJXjgEEyQpK1At2Ak4jXGBECJ1hY7BCaGYcC7YBLQvLukmdN7AuO3tEJYO6t5CnyLUMQbjdfKhhxuf3mGrU9rCzn-6AVofnY4ZblOuwpDeQwqr3GYnp0H3cdXpPv38PwdHre6iu_i9z8D84X4-fSpmr4_P07tZYSireWGtlEg2jWQMGZNNNsLIprXjeIYSTllby4oIWQmJW12J2lqtuUEW8boh9Axc79quhvCxdjGppY_GddmHC-uoMKESVUxwmtGrf-girIc-m1NYcC7RSGbq8pdaN0tn1WrwSz1s1d8CM3C7Aza-c9u9jpEag1ILNeahxjzUGJT6CUp9qfnb8_ii3w4ZhxQ</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Sprinzl, Martin F.</creator><creator>Weinmann, Arndt</creator><creator>Lohse, Nikola</creator><creator>Tönissen, Hanna</creator><creator>Koch, Sandra</creator><creator>Schattenberg, Jörn</creator><creator>Hoppe‐Lotichius, Maria</creator><creator>Zimmermann, Tim</creator><creator>Galle, Peter R.</creator><creator>Hansen, Torsten</creator><creator>Otto, Gerd</creator><creator>Schuchmann, Marcus</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation</title><author>Sprinzl, Martin F. ; Weinmann, Arndt ; Lohse, Nikola ; Tönissen, Hanna ; Koch, Sandra ; Schattenberg, Jörn ; Hoppe‐Lotichius, Maria ; Zimmermann, Tim ; Galle, Peter R. ; Hansen, Torsten ; Otto, Gerd ; Schuchmann, Marcus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3486-dd9909bb9440cc312b7c9bfd0157c32634f8952795791fa578ddaa6c0d068b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>body mass index</topic><topic>Confidence intervals</topic><topic>Fatty Liver - etiology</topic><topic>Fatty Liver - pathology</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>glycosylated hemoglobin</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Liver Transplantation - adverse effects</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - etiology</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>obesity</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sprinzl, Martin F.</creatorcontrib><creatorcontrib>Weinmann, Arndt</creatorcontrib><creatorcontrib>Lohse, Nikola</creatorcontrib><creatorcontrib>Tönissen, Hanna</creatorcontrib><creatorcontrib>Koch, Sandra</creatorcontrib><creatorcontrib>Schattenberg, Jörn</creatorcontrib><creatorcontrib>Hoppe‐Lotichius, Maria</creatorcontrib><creatorcontrib>Zimmermann, Tim</creatorcontrib><creatorcontrib>Galle, Peter R.</creatorcontrib><creatorcontrib>Hansen, Torsten</creatorcontrib><creatorcontrib>Otto, Gerd</creatorcontrib><creatorcontrib>Schuchmann, Marcus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sprinzl, Martin F.</au><au>Weinmann, Arndt</au><au>Lohse, Nikola</au><au>Tönissen, Hanna</au><au>Koch, Sandra</au><au>Schattenberg, Jörn</au><au>Hoppe‐Lotichius, Maria</au><au>Zimmermann, Tim</au><au>Galle, Peter R.</au><au>Hansen, Torsten</au><au>Otto, Gerd</au><au>Schuchmann, Marcus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2013-01</date><risdate>2013</risdate><volume>26</volume><issue>1</issue><spage>67</spage><epage>74</epage><pages>67-74</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
The metabolic syndrome (MetS) might contribute to morbidity after orthotopic liver transplantation (OLT). For this reason, we searched for MetS‐associated risk factors and analyzed the link with nonalcoholic fatty liver disease (NAFLD) in OLT recipients. De novo MetS affected 32.9% of our cohort (n = 170) within 2 years after OLT. Multivariate analysis identified glycosylated hemoglobin (HbA1c) levels ≥5% [odds ratio (OR) = 3.5; 95% confidence interval (CI) = 1.56–8.13, P = 0.003], diabetes mellitus (OR = 4.31, CI = 1.69–10.99, P = 0.002), and arterial hypertension (OR = 4.59, CI = 1.46–14.49, P = 0.009) as independent risk factors for de novo MetS. MetS incidence correlated with steroid dosage after OLT (5.2 ± 2.4 mg/day vs. 7.1 ± 4.7 mg/day, P = 0.014), and was linked to NAFLD (P = 0.001) via obesity (OR = 4.67, CI = 1.55–14.1, P = 0.006) and dyslipidemia (OR = 4.23, CI = 1.35–13.3, P = 0.013) post‐OLT. In conclusion, we were able to identify low threshold HbA1c as a novel risk factor for MetS after OLT and described a link of MetS with NAFLD in transplant organs. This study also indicated that steroid treatment is associated with MetS rates after OLT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23126674</pmid><doi>10.1111/j.1432-2277.2012.01576.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2013-01, Vol.26 (1), p.67-74 |
| issn | 0934-0874 1432-2277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1239054763 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged body mass index Confidence intervals Fatty Liver - etiology Fatty Liver - pathology Glycated Hemoglobin A - analysis glycosylated hemoglobin Humans Liver cirrhosis Liver diseases Liver Transplantation - adverse effects Metabolic syndrome Metabolic Syndrome - etiology Middle Aged Multivariate analysis obesity Retrospective Studies Risk Factors Transplants & implants |
| title | Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T04%3A10%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20syndrome%20and%20its%20association%20with%20fatty%20liver%20disease%20after%20orthotopic%20liver%20transplantation&rft.jtitle=Transplant%20international&rft.au=Sprinzl,%20Martin%20F.&rft.date=2013-01&rft.volume=26&rft.issue=1&rft.spage=67&rft.epage=74&rft.pages=67-74&rft.issn=0934-0874&rft.eissn=1432-2277&rft_id=info:doi/10.1111/j.1432-2277.2012.01576.x&rft_dat=%3Cproquest_pubme%3E1239054763%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1766903905&rft_id=info:pmid/23126674&rfr_iscdi=true |